Discovery of a new class of orthosteric antagonists with nanomolar potency at extrasynaptic GABA A receptors.

Autor: Falk-Petersen CB; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen Ø, Denmark., Tsonkov TM; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen Ø, Denmark., Nielsen MS; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen Ø, Denmark., Harpsøe K; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen Ø, Denmark., Bundgaard C; Translational DMPK, H. Lundbeck A/S, Ottiliavej 9, 2500, Valby, Denmark., Frølund B; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen Ø, Denmark., Kristiansen U; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen Ø, Denmark., Gloriam DE; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen Ø, Denmark., Wellendorph P; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen Ø, Denmark. pw@sund.ku.dk.

Publikováno v: Scientific reports [Sci Rep] 2020 Jun 22; Vol. 10 (1), pp. 10078. Date of Electronic Publication: 2020 Jun 22.

Structure-Activity Studies of 3,9-Diazaspiro[5.5]undecane-Based γ-Aminobutyric Acid Type A Receptor Antagonists with Immunomodulatory Effect.

Autor: Bavo F; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark., de-Jong H; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark., Petersen J; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark., Falk-Petersen CB; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark., Löffler R; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark., Sparrow E; Antibody and Vaccine Group, Centre for Cancer Immunology, MP127, University of Southampton Faculty of Medicine, Southampton, Hants SO16 6YD, United Kingdom., Rostrup F; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark., Eliasen JN; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark., Wilhelmsen KS; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark., Barslund K; Translational DMPK, H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Denmark., Bundgaard C; Translational DMPK, H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Denmark., Nielsen B; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark., Kristiansen U; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark., Wellendorph P; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark., Bogdanov Y; Antibody and Vaccine Group, Centre for Cancer Immunology, MP127, University of Southampton Faculty of Medicine, Southampton, Hants SO16 6YD, United Kingdom., Frølund B; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2021 Dec 23; Vol. 64 (24), pp. 17795-17812. Date of Electronic Publication: 2021 Dec 15.

Delineation of the functional properties exhibited by the Zinc-Activated Channel (ZAC) and its high-frequency Thr ¹²⁸ Ala variant (rs2257020) in Xenopus oocytes.

Autor: Madjroh N; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen Ø, Denmark., Davies PA; Department of Neuroscience, Tufts University School of Medicine, Boston, MA, USA., Smalley JL; Department of Neuroscience, Tufts University School of Medicine, Boston, MA, USA., Kristiansen U; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen Ø, Denmark., Söderhielm PC; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen Ø, Denmark., Jensen AA; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen Ø, Denmark. Electronic address: aaj@sund.ku.dk.

Publikováno v: Pharmacological research [Pharmacol Res] 2021 Jul; Vol. 169, pp. 105653. Date of Electronic Publication: 2021 May 04.

Differences in kinetics of structurally related competitive GABA(A) receptor antagonists

Autor: Vestergaard, HT, Cannillo, C, Frolund, B, Kristiansen, U

Publikováno v: Vestergaard, HT, Cannillo, C, Frolund, B & Kristiansen, U 2007, ' Differences in kinetics of structurally related competitive GABA(A) receptor antagonists. ' Neuropharmacology, vol. 52, pp. 873-882 .

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pure_au_____::72db0c7a759806b81b426cac02763353
https://pure.au.dk/portal/da/publications/differences-in-kinetics-of-structurally-related-competitive-gabaa-receptor-antagonists(df7936c0-c102-11db-bee9-02004c4f4f50).html

High-Frequency Imaging Reveals Synchronised Delta- and Theta-Band Ca 2+ Oscillations in the Astrocytic Soma In Vivo.

Autor: Péter, Márton^1,2 (AUTHOR) peter.marton@ttk.hu, Héja, László¹ (AUTHOR) heja.laszlo@ttk.hu

Publikováno v: International Journal of Molecular Sciences. Aug2024, Vol. 25 Issue 16, p8911. 13p.