Výsledky vyhledávání - "Kristian W. Fried"

Demonstrating the protective effect of a 70-year-old occupational exposure limit against pneumoconiosis caused by mica

Publikováno v: Toxicology and industrial health. 38(2)

Workers involved in crushing, milling, screening, and bagging of mica scrap are at increased risk to develop pneumoconiosis, a progressive material overloading of the lung that can lead to fibrosis and, in the later stages, to dyspnea. Pneumoconiosis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5572668404dc2a366fcf4c1a5f8b9b3
https://pubmed.ncbi.nlm.nih.gov/35230205

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2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) reverses hyperglycemia in a type II diabetes mellitus rat model by a mechanism unrelated to PPARγ

Autor: Karl K. Rozman, Bo Kong, Grace L. Guo, Kristian W. Fried, Noriko Esterly

Publikováno v: Drug and Chemical Toxicology. 33:261-268

It has been asserted that exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) increases the risk for diabetes mellitus in humans, observable as hyperglycemia resulting from insulin resistance. There is no animal model for the induction of diabetes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc33bd2a41690eb8851981f7d7745c6b
https://doi.org/10.3109/01480540903390026

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From Dioxin to Drug Lead—The Development of 2,3,7,8-Tetrachlorophenothiazine

Autor: Christopher M. Schneider, Kristian W. Fried, Apurba Datta, Karl-Werner Schramm, Antonius Kettrup, Paul F. Terranova, Dieter Lenoir, Douglas R. Powell, Claudia Corsten, Karl K. Rozman, Naima Chahbane, Gunda I. Georg

Publikováno v: ChemMedChem. 2:890-897

Polychlorinated dibenzo-p-dioxins are persistent environmental pollutants. The most potent congener, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), causes a wasting syndrome and is a potent carcinogen and immunosuppressant in the rat at high doses. Howe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e555f300b61bcafa6e98b2e2473a277f
https://doi.org/10.1002/cmdc.200700005

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Toxicity of Selected Chemicals

Autor: Ladislaus Szinicz, Gisela H. Degen, Karl-Heinz Summer, Kristian W. Fried, M. W. Anders, Helmut Greim, Paul J. A. Borm, S. Halbach, Thomas Zilker, J. William Owens, Herrmann Kappus, Karl K. Rozman, Wolfgang Dekant

Publikováno v: Toxicology and Risk Assessment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::975ea3e976ec0860588d701b4783c277
https://doi.org/10.1002/9780470868959.ch6

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Relationship between aryl hydrocarbon receptor-affinity and the induction of EROD activity by 2,3,7,8-tetrachlorinated phenothiazine and derivatives

Autor: Kristian W. Fried, Karl-Werner Schramm, Claudia Corsten, David R. Bell, Karl K. Rozman, Walkiria Levy Lopez, Rana Bazzi

Publikováno v: Toxicology and applied pharmacology. 224(2)

Reported herein are semi-empirical calculations of the molecular geometry of TCDD, TCPT, TCPT-sulfoxide (TCPT-O), TCPT-sulfone (TCPT-O(2)), N-methyl-TCPT (Me-TCPT), N-methyl-TCPT-sulfoxide (Me-TCPT-O), and N-methyl-TCPT-sulfone (Me-TCPT-O(2)), the ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc123a00454b550dc08442583a8f066e
https://pubmed.ncbi.nlm.nih.gov/17761204

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