Zobrazeno 1 - 10
of 196
pro vyhledávání: '"Kristian Unger"'
Autor:
Benedek Dankó, Julia Hess, Kristian Unger, Daniel Samaga, Christoph Walz, Axel Walch, Na Sun, Philipp Baumeister, Peter Y. F. Zeng, Franziska Walter, Sebastian Marschner, Richard Späth, Olivier Gires, Timm Herkommer, Ramin Dazeh, Thaina Matos, Lisa Kreutzer, Johann Matschke, Katharina Eul, Frederick Klauschen, Ulrike Pflugradt, Martin Canis, Ute Ganswindt, Joe S. Mymryk, Barbara Wollenberg, Anthony C. Nichols, Claus Belka, Horst Zitzelsberger, Kirsten Lauber, Martin Selmansberger
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-20 (2024)
Abstract Head and Neck Squamous Cell Carcinoma (HNSCC) is a heterogeneous malignancy that remains a significant challenge in clinical management due to frequent treatment failures and pronounced therapy resistance. While metabolic dysregulation appea
Externí odkaz:
https://doaj.org/article/478152ef0db84845b323352406d212bd
Autor:
Raphael Bodensohn, Daniel F. Fleischmann, Sebastian H. Maier, Vasiliki Anagnostatou, Sylvia Garny, Alexander Nitschmann, Marcel Büttner, Johannes Mücke, Stephan Schönecker, Kristian Unger, Elgin Hoffmann, Frank Paulsen, Daniela Thorwarth, Adrien Holzgreve, Nathalie L. Albert, Stefanie Corradini, Ghazaleh Tabatabai, Claus Belka, Maximilian Niyazi
Publikováno v:
Clinical and Translational Radiation Oncology, Vol 45, Iss , Pp 100706- (2024)
Background and purpose: The PRIDE trial (NOA-28; ARO-2022-12; NCT05871021) is scheduled to start recruitment in October 2023. Its primary objective is to enhance median overall survival (OS), compared to historical median OS rates, in patients with m
Externí odkaz:
https://doaj.org/article/2e39a454d584431f845c26def0ecbd15
Autor:
Leon Emanuel Schnöller, Daniel Piehlmaier, Peter Weber, Nikko Brix, Daniel Felix Fleischmann, Alexander Edward Nieto, Martin Selmansberger, Theresa Heider, Julia Hess, Maximilian Niyazi, Claus Belka, Kirsten Lauber, Kristian Unger, Michael Orth
Publikováno v:
Radiation Oncology, Vol 18, Iss 1, Pp 1-17 (2023)
Abstract Despite intensive basic scientific, translational, and clinical efforts in the last decades, glioblastoma remains a devastating disease with a highly dismal prognosis. Apart from the implementation of temozolomide into the clinical routine,
Externí odkaz:
https://doaj.org/article/c26cb10a07c6433199767a70dbfa306c
Autor:
Laure-Alix Clerbaux, Pierre Cordier, Nina Desboeufs, Kristian Unger, Peter Leary, Gabriel Semere, Yannick Boege, Lap Kwan Chan, Chantal Desdouets, Massimo Lopes, Achim Weber
Publikováno v:
JHEP Reports, Vol 5, Iss 10, Pp 100838- (2023)
Background & Aims: Mcl-1, an antiapoptotic protein overexpressed in many tumours, including hepatocellular carcinoma (HCC), represents a promising target for cancer treatment. Although Mcl-1 non-apoptotic roles might critically influence the therapeu
Externí odkaz:
https://doaj.org/article/5f8d2726cb3b4e978c92f8e81851c77a
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionMesenchymal stem cells (MSCs) are considered to be the most promising stem cell type for cell-based therapies in regenerative medicine. Based on their potential to home to diseased body sites following a therapeutically application, these
Externí odkaz:
https://doaj.org/article/0651d8af322a4ef5ae9868c3ad82c5d1
Autor:
Henrik Schinke, Enxian Shi, Zhongyang Lin, Tanja Quadt, Gisela Kranz, Jiefu Zhou, Hongxia Wang, Julia Hess, Steffen Heuer, Claus Belka, Horst Zitzelsberger, Udo Schumacher, Sandra Genduso, Kristoffer Riecken, Yujing Gao, Zhengquan Wu, Christoph A. Reichel, Christoph Walz, Martin Canis, Kristian Unger, Philipp Baumeister, Min Pan, Olivier Gires
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-25 (2022)
Abstract Background Epidermal growth factor receptor (EGFR) is both a driver oncogene and a therapeutic target in advanced head and neck squamous cell carcinoma (HNSCC). However, response to EGFR treatment is inconsistent and lacks markers for treatm
Externí odkaz:
https://doaj.org/article/95531d59b79a463e83a7c5658acca70f
Autor:
Kristian Unger, Julia Hess, Vera Link, Alexander Buchner, Chukwuka Eze, Minglun Li, Christian Stief, Thomas Kirchner, Frederick Klauschen, Horst Zitzelsberger, Maximilian Niyazi, Ute Ganswindt, Nina-Sophie Schmidt-Hegemann, Claus Belka
Publikováno v:
Clinical and Translational Radiation Oncology, Vol 39, Iss , Pp 100586- (2023)
Purpose: In prostate cancer, the indication to irradiate the pelvic lymphatic pathways in clinical node-negative patients is solely based on clinical nomograms. To define biological risk patterns of lymphatic spread, we studied DNA-methylation and ge
Externí odkaz:
https://doaj.org/article/ce00fc257e5d4dbfb1ffece614c15852
Autor:
Leon Emanuel Schnöller, Valerie Albrecht, Nikko Brix, Alexander Edward Nieto, Daniel Felix Fleischmann, Maximilian Niyazi, Julia Hess, Claus Belka, Kristian Unger, Kirsten Lauber, Michael Orth
Publikováno v:
Radiation Oncology, Vol 17, Iss 1, Pp 1-11 (2022)
Abstract Background Inherent resistance to radio/chemotherapy is one of the major reasons for early recurrence, treatment failure, and dismal prognosis of glioblastoma. Thus, the identification of resistance driving regulators as prognostic and/or pr
Externí odkaz:
https://doaj.org/article/f6855d1686394c15a76931f9485152f0
Autor:
Ulrike Schoetz, Diana Klein, Julia Hess, Seyd Shnayien, Steffen Spoerl, Michael Orth, Samet Mutlu, Roman Hennel, Anja Sieber, Ute Ganswindt, Benedikt Luka, Andreas R. Thomsen, Kristian Unger, Verena Jendrossek, Horst Zitzelsberger, Nils Blüthgen, Claus Belka, Steffen Unkel, Bertram Klinger, Kirsten Lauber
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-14 (2021)
Externí odkaz:
https://doaj.org/article/fbf13515bb4d4cd0a548292129080737
Autor:
Sebastian Burkart, Christopher Weusthof, Karam Khorani, Sonja Steen, Fabian Stögbauer, Kristian Unger, Julia Hess, Horst Zitzelsberger, Claus Belka, Ina Kurth, Jochen Hess
Publikováno v:
Cancers, Vol 15, Iss 6, p 1655 (2023)
Purpose: Identification of molecularly-defined cancer subgroups and targeting tumor-specific vulnerabilities have a strong potential to improve treatment response and patient outcomes but remain an unmet challenge of high clinical relevance, especial
Externí odkaz:
https://doaj.org/article/be93a4318f674595bc7271e7f515a107