Zobrazeno 1 - 10
of 157
pro vyhledávání: '"Kristian Pietras"'
Autor:
Martin Lauss, Bengt Phung, Troels Holz Borch, Katja Harbst, Kamila Kaminska, Anna Ebbesson, Ingrid Hedenfalk, Joan Yuan, Kari Nielsen, Christian Ingvar, Ana Carneiro, Karolin Isaksson, Kristian Pietras, Inge Marie Svane, Marco Donia, Göran Jönsson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Immune checkpoint blockade (ICB) has improved outcome for patients with metastatic melanoma but not all benefit from treatment. Several immune- and tumor intrinsic features are associated with clinical response at baseline. However, we need
Externí odkaz:
https://doaj.org/article/106ca4c71cf547479bf6c2a98fc56d68
Autor:
Kristian Pietras, Jonas Sjölund
Publikováno v:
Upsala Journal of Medical Sciences, Vol 129, Pp 1-5 (2024)
The complex interplay between genetically diverse tumor cells and their microenvironment significantly influences cancer progression and therapeutic responses. This review highlights recent findings on cellular plasticity and heterogeneity within the
Externí odkaz:
https://doaj.org/article/b15f6782c06b4255a8bbb5f0c9f2d1fc
Autor:
Mikkel Morsing Bagger, Jonas Sjölund, Jiyoung Kim, Katharina Theresa Kohler, René Villadsen, Abbas Jafari, Moustapha Kassem, Kristian Pietras, Lone Rønnov-Jessen, Ole William Petersen
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-19 (2024)
Abstract Background Human breast cancer most frequently originates within a well-defined anatomical structure referred to as the terminal duct lobular unit (TDLU). This structure is endowed with its very own lobular fibroblasts representing one out o
Externí odkaz:
https://doaj.org/article/a46f3b614fcd4ea7b71577a94fffc26e
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/8a36cb72fe5746e796335486247f6c37
Autor:
Konstantinos S. Papadakos, Alexander Ekström, Piotr Slipek, Eleni Skourti, Steven Reid, Kristian Pietras, Anna M. Blom
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-19 (2022)
Abstract Background Sushi domain-containing protein 4 (SUSD4) is a recently discovered protein with unknown cellular functions. We previously revealed that SUSD4 can act as complement inhibitor and as a potential tumor suppressor. Methods In a syngen
Externí odkaz:
https://doaj.org/article/ffa37e609d214cb0acb3b113686e5eb0
Publikováno v:
Molecular Oncology, Vol 16, Iss 2, Pp 405-421 (2022)
Pericytes conceivably play important roles in the tumour microenvironment of glioblastoma multiforme (GBM) by allowing for an aberrant vasculature and acting as a component in the perivascular niche that supports glioma stem‐like cells. However, a
Externí odkaz:
https://doaj.org/article/c0278db716d644e6bdaadcd0a11053b9
Publikováno v:
PLoS ONE, Vol 18, Iss 2, p e0279597 (2023)
Developments in sequencing technologies and the sequencing of an ever-increasing number of genomes have revolutionised studies of biodiversity and organismal evolution. This accumulation of data has been paralleled by the creation of numerous public
Externí odkaz:
https://doaj.org/article/69dea6b5b3e444f7a471fb781f72b4a8
Autor:
Adriana Sanna, Bengt Phung, Shamik Mitra, Martin Lauss, Jiyeon Choi, Tongwu Zhang, Ching-Ni Njauw, Eugenia Cordero, Katja Harbst, Frida Rosengren, Rita Cabrita, Iva Johansson, Karolin Isaksson, Christian Ingvar, Ana Carneiro, Kevin Brown, Hensin Tsao, My Andersson, Kristian Pietras, Göran Jönsson
Publikováno v:
JCI Insight, Vol 7, Iss 19 (2022)
Cellular stress contributes to the capacity of melanoma cells to undergo phenotype switching into highly migratory and drug-tolerant dedifferentiated states. Such dedifferentiated melanoma cell states are marked by loss of melanocyte-specific gene ex
Externí odkaz:
https://doaj.org/article/37d81ad9a39246c69b971323fad1eabb
Autor:
Katarzyna Radke, Karin Hansson, Jonas Sjölund, Magdalena Wolska, Jenny Karlsson, Javanshir Esfandyari, Kristian Pietras, Kristina Aaltonen, David Gisselsson, Daniel Bexell
Publikováno v:
Translational Oncology, Vol 14, Iss 8, Pp 101149- (2021)
High-risk neuroblastoma has a poor prognosis despite intense treatment, demonstrating the need for new therapeutic strategies. Here we evaluated the effects of rigosertib (ON-01910.Na) in preclinical models of high-risk neuroblastoma. Among several h
Externí odkaz:
https://doaj.org/article/6744e2c17bf2479da962240e572b1b78
Autor:
Tânia D. F. Costa, Ting Zhuang, Julie Lorent, Emilia Turco, Helene Olofsson, Miriam Masia-Balague, Miao Zhao, Parisa Rabieifar, Neil Robertson, Raoul Kuiper, Jonas Sjölund, Matthias Spiess, Pablo Hernández-Varas, Uta Rabenhorst, Pernilla Roswall, Ran Ma, Xiaowei Gong, Johan Hartman, Kristian Pietras, Peter D. Adams, Paola Defilippi, Staffan Strömblad
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Oncogene induced senescence protects cells from unrestricted growth and cancer. Here, the authors show that PAK4 overrides this senescence in breast cancer cells through phosphorylation of RELB, thereby inhibiting transcription of the senescence regu
Externí odkaz:
https://doaj.org/article/b1b8d976c5c54a27ab395cced065f0c0