Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Kristian M. Müller"'
Autor:
Hendrik Gruß, Rebecca C. Feiner, Ridhiwan Mseya, David C. Schröder, Michał Jewgiński, Kristian M. Müller, Rafał Latajka, Antoine Marion, Norbert Sewald
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 18, Iss 1, Pp 1-12 (2022)
The development of peptide stapling techniques to stabilise α-helical secondary structure motifs of peptides led to the design of modulators of protein–protein interactions, which had been considered undruggable for a long time. We disclose a nove
Externí odkaz:
https://doaj.org/article/b1e73b21829c4343991dd07924fa3253
Publikováno v:
Viruses, Vol 15, Iss 5, p 1174 (2023)
Research on adeno-associated virus (AAV) and its recombinant vectors as well as on fluorescence microscopy imaging is rapidly progressing driven by clinical applications and new technologies, respectively. The topics converge, since high and super-re
Externí odkaz:
https://doaj.org/article/a728cf09e6bd42099f087be1d8681eaa
Autor:
Lennard Karsten, Lukas Goett-Zink, Julian Schmitz, Raimund Hoffrogge, Alexander Grünberger, Tilman Kottke, Kristian M. Müller
Publikováno v:
Biosensors, Vol 12, Iss 5, p 271 (2022)
pH-sensitive fluorescent proteins as genetically encoded pH sensors are promising tools for monitoring intra- and extracellular pH. However, there is a lack of ratiometric pH sensors, which offer a good dynamic range and can be purified and applied e
Externí odkaz:
https://doaj.org/article/1cce7ff657664e1f87e45761c5734923
Autor:
Dinh To Le, Kristian M. Müller
Publikováno v:
Life, Vol 11, Iss 4, p 334 (2021)
Virus-like particles (VLPs) are increasingly used for vaccine development and drug delivery. Assembly of VLPs from purified monomers in a chemically defined reaction is advantageous compared to in vivo assembly, because it avoids encapsidation of hos
Externí odkaz:
https://doaj.org/article/719a5dd525394023b80c8ebfa377421b
Autor:
Georg Falck, Kristian M. Müller
Publikováno v:
Antibodies, Vol 7, Iss 1, p 4 (2018)
Strategies for site-specific modification of proteins have increased in number, complexity, and specificity over the last years. Such modifications hold the promise to broaden the use of existing biopharmaceuticals or to tailor novel proteins for the
Externí odkaz:
https://doaj.org/article/3da3f462f84d4127b96d7c0206d84b7e
Publikováno v:
ACS synthetic biology. 11(11)
Virus-like particles (VLPs) have been used for numerous pharmaceutical applications, particularly vaccination and drug delivery. Recombinant adeno-associated virus (rAAV), a leading candidate in gene therapy, has been proposed as a vaccine scaffold,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::505f9bf5c5a91856bddac8f9c02334d2
https://pubmed.ncbi.nlm.nih.gov/36279242
https://pubmed.ncbi.nlm.nih.gov/36279242
Autor:
Rebecca C. Feiner, David C. Schröder, Antoine Marion, Norbert Sewald, Isabell Kemker, Kristian M. Müller
Publikováno v:
Journal of Medicinal Chemistry. 64:586-601
An array of l- and d-halotryptophans with different substituents at the indole moiety was synthesized employing either enzymatic halogenation by halogenases or incorporation of haloindoles using tryptophan synthase. Introduction of these Trp derivati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1771d700ac252daab0af281815a9e64
https://doi.org/10.1021/acs.jmedchem.0c01536
https://doi.org/10.1021/acs.jmedchem.0c01536
The vaccine ChAdOx1 nCoV-19 has been widely used, but its purity has been disputed because of rare side effects. We used Nanopore sequencing to assess the sequence and genetic purity of a vaccine dose. As we were lacking a reference sequence for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d730746f77bcd088df52ac2cafbc390
https://doi.org/10.21203/rs.3.rs-799338/v1
https://doi.org/10.21203/rs.3.rs-799338/v1
Autor:
Georg Falck, Kristian M. Müller, Tobias Krüger, Thomas Dierks, Norbert Sewald, Mareile Boschanski, Benjamin Müller, Lennard Karsten, Marcus Gerlach, Sarfaraz Alam
Publikováno v:
Bioconjugate chemistry. 32(6)
Multiple, site-specific protein conjugation is increasingly attractive for the generation of antibody-drug conjugates (ADCs). As it is important to control the number and position of cargoes in an ADC, position-selective generation of reactive sites
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aa2e35cdfd6f1d39c91be05daf981ef
https://pubmed.ncbi.nlm.nih.gov/34060308
https://pubmed.ncbi.nlm.nih.gov/34060308
Publikováno v:
Biochemistry. 58:1043-1047
The epidermal growth factor receptor (EGFR) is a transmembrane protein involved in cell signaling processes, and dysregulation of its activity often drives tumor growth. EGFR is a clinically validated tumor marker and target for antibodies and tyrosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0804907244f0d4a06e03b23bd189fc9a
https://doi.org/10.1021/acs.biochem.9b00021
https://doi.org/10.1021/acs.biochem.9b00021