Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Kristian Hollingsworth"'
Autor:
Kristian Hollingsworth, Antonio Di Maio, Sarah-Jane Richards, Jean-Baptiste Vendeville, David E. Wheatley, Claire E. Council, Tessa Keenan, Hélène Ledru, Harriet Chidwick, Kun Huang, Fabio Parmeggiani, Andrea Marchesi, Wengang Chai, Ryan McBerney, Tomasz P. Kamiński, Matthew R. Balmforth, Alexandra Tamasanu, James D. Finnigan, Carl Young, Stuart L. Warriner, Michael E. Webb, Martin A. Fascione, Sabine Flitsch, M. Carmen Galan, Ten Feizi, Matthew I. Gibson, Yan Liu, W. Bruce Turnbull, Bruno Linclau
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Glycan-mediated interactions play a crucial role in biology and medicine, influencing signalling, immune responses, and disease pathogenesis. However, the use of glycans in biosensing and diagnostics is limited by cross-reactivity, as certai
Externí odkaz:
https://doaj.org/article/45fc41374e2f4ce2b12a1822076a1c13
Autor:
Simon J. Charnock, Andrea Marchesi, Sabine L. Flitsch, W. Bruce Turnbull, Kun Huang, Peter Both, Helene Ledru, Kristian Hollingsworth, M. Carmen Galan, Ashley P. Mattey, Edward Pallister, Fabio Parmeggiani
Publikováno v:
Organic & Biomolecular Chemistry
Huang, K, Marchesi, A, Hollingsworth, K, Both, P, Mattey, A P, Pallister, E, Ledru, H, Charnock, S, Galan, M C, Turnbull, W B, Parmeggiani, F & Flitsch, S L 2020, ' Biochemical characterisation of an α1,4 galactosyltransferase from Neisseria weaveri for the synthesis of α1,4-linked galactosides ', Organic & biomolecular chemistry . https://doi.org/10.1039/D0OB00407C
Huang, K, Marchesi, A, Hollingsworth, K, Both, P, Mattey, A P, Pallister, E, Ledru, H, Charnock, S J, Galan, M C, Turnbull, W B, Parmeggiani, F & Flitsch, S L 2020, ' Biochemical characterisation of an α1,4 galactosyltransferase from Neisseria weaveri for the synthesis of α1,4-linked galactosides ', Organic and Biomolecular Chemistry, vol. 18, no. 16, pp. 3142-3148 . https://doi.org/10.1039/d0ob00407c
Huang, K, Marchesi, A, Hollingsworth, K, Both, P, Mattey, A P, Pallister, E, Ledru, H, Charnock, S, Galan, M C, Turnbull, W B, Parmeggiani, F & Flitsch, S L 2020, ' Biochemical characterisation of an α1,4 galactosyltransferase from Neisseria weaveri for the synthesis of α1,4-linked galactosides ', Organic & biomolecular chemistry . https://doi.org/10.1039/D0OB00407C
Huang, K, Marchesi, A, Hollingsworth, K, Both, P, Mattey, A P, Pallister, E, Ledru, H, Charnock, S J, Galan, M C, Turnbull, W B, Parmeggiani, F & Flitsch, S L 2020, ' Biochemical characterisation of an α1,4 galactosyltransferase from Neisseria weaveri for the synthesis of α1,4-linked galactosides ', Organic and Biomolecular Chemistry, vol. 18, no. 16, pp. 3142-3148 . https://doi.org/10.1039/d0ob00407c
The human cell surface trisaccharide motifs globotriose and P1 antigen play key roles in infections by pathogenic bacteria, which makes them important synthetic targets as antibacterial agents. Enzymatic strategies to install the terminal α1,4-galac
Autor:
Jean-Baptiste Vendeville, Mark E. Light, M. Carmen Galan, W. Bruce Turnbull, Martin A. Fascione, Jesús Jiménez-Barbero, Harriet S Chidwick, Tessa Keenan, Bruno Linclau, Pablo Valverde, Sabine L. Flitsch, Helene Ledru, Kler Huonnic, Nicholas J. Turner, Kristian Hollingsworth, Ashley P. Mattey, Kun Huang
Publikováno v:
Chemical Communications
Valverde, P, Vendeville, J-B, Hollingsworth, K, Mattey, A P, Keenan, T, Chidwick, H, Ledru, H, Huonnic, K, Huang, K, Light, M E, Turner, N, Jiménez-Barbero, J, Galan, M C, Fascione, M A, Flitsch, S, Turnbull, W B & Linclau, B 2020, ' Chemoenzymatic synthesis of 3-deoxy-3-fluoro-l-fucose and its enzymatic incorporation into glycoconjugates ', Chemical communications (Cambridge, England), vol. (2020) 56, pp. 6408-6411 . https://doi.org/10.1039/d0cc02209h
Valverde, P, Vendeville, J-B, Hollingsworth, K, Mattey, A P, Keenan, T, Chidwick, H, Ledru, H, Huonnic, K, Huang, K, Light, M E, Turner, N, Jiménez-Barbero, J, Galan, M C, Fascione, M A, Flitsch, S, Turnbull, W B & Linclau, B 2020, ' Chemoenzymatic synthesis of 3-deoxy-3-fluoro-l-fucose and its enzymatic incorporation into glycoconjugates ', Chemical communications (Cambridge, England), vol. (2020) 56, pp. 6408-6411 . https://doi.org/10.1039/d0cc02209h
The first synthesis of 3-deoxy-3-fluoro-l-fucose is presented, which employs a d- to l-sugar translation strategy, and involves an enzymatic oxidation of 3-deoxy-3-fluoro-l-fucitol. Enzymatic activation (FKP) and glycosylation using an α-1,2 and an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b05ca09210642532c7ca105daa5f635d
https://zenodo.org/record/3778001
https://zenodo.org/record/3778001
Autor:
Helene Ledru, Jolanda M. van Munster, Peter Both, Ashley P. Mattey, Gregory S Bulmer, Kristian Hollingsworth, W. Bruce Turnbull, M. Carmen Galan, Fabio Parmeggiani, Andrea Marchesi, Jordi Mas Pons, Sabine L. Flitsch, Edward Pallister, Kun Huang
Publikováno v:
Organic & Biomolecular Chemistry
Huang, K, Parmeggiani, F, Ledru, H, Hollingsworth, K, Pons, J M, Marchesi, A, Both, P, Mattey, A P, Pallister, E, Bulmer, G S, Munster, J M V, Turnbull, W B, Galan, M C & Flitsch, S L 2019, ' Enzymatic synthesis of N-acetyllactosamine from lactose enabled by recombinant β1,4-galactosyltransferases ', Organic & biomolecular chemistry . https://doi.org/10.1039/C9OB01089K
Huang, K, Parmeggiani, F, Ledru, H, Hollingsworth, K, Mas Pons, J, Marchesi, A, Both, P, Mattey, A P, Pallister, E, Bulmer, G S, van Munster, J M, Turnbull, W B, Galan, C & Flitsch, S L 2019, ' Enzymatic synthesis of N-acetyllactosamine from lactose enabled by recombinant β1,4-galactosyltransferases ', Organic and Biomolecular Chemistry, vol. 17, no. 24, pp. 5920-5924 . https://doi.org/10.1039/C9OB01089K
Huang, K, Parmeggiani, F, Ledru, H, Hollingsworth, K, Pons, J M, Marchesi, A, Both, P, Mattey, A P, Pallister, E, Bulmer, G S, Munster, J M V, Turnbull, W B, Galan, M C & Flitsch, S L 2019, ' Enzymatic synthesis of N-acetyllactosamine from lactose enabled by recombinant β1,4-galactosyltransferases ', Organic & biomolecular chemistry . https://doi.org/10.1039/C9OB01089K
Huang, K, Parmeggiani, F, Ledru, H, Hollingsworth, K, Mas Pons, J, Marchesi, A, Both, P, Mattey, A P, Pallister, E, Bulmer, G S, van Munster, J M, Turnbull, W B, Galan, C & Flitsch, S L 2019, ' Enzymatic synthesis of N-acetyllactosamine from lactose enabled by recombinant β1,4-galactosyltransferases ', Organic and Biomolecular Chemistry, vol. 17, no. 24, pp. 5920-5924 . https://doi.org/10.1039/C9OB01089K
Utilising a fast and sensitive screening method based on imidazolium-tagged probes, we report unprecedented reversible activity of bacterial β1,4-galactosyltransferases to catalyse the transgalactosylation from lactose to N-acetylglucosamine to form