Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Kristian E. Baker"'
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
Nonsense-mediated mRNA decay (NMD) is a quality control pathway that recognizes and degrades transcripts harbouring nonsense mutations. Here the authors show that the ATPase activity of UPF1 mediates functional interactions between the NMD machinery
Externí odkaz:
https://doaj.org/article/6c4b427687ad4141ab4421be6022f015
Autor:
Jenna E. Smith, Juan R. Alvarez-Dominguez, Nicholas Kline, Nathan J. Huynh, Sarah Geisler, Wenqian Hu, Jeff Coller, Kristian E. Baker
Publikováno v:
Cell Reports, Vol 7, Iss 6, Pp 1858-1866 (2014)
High-throughput gene expression analysis has revealed a plethora of previously undetected transcripts in eukaryotic cells. In this study, we investigate >1,100 unannotated transcripts in yeast predicted to lack protein-coding capacity. We show that a
Externí odkaz:
https://doaj.org/article/7aa099a3fc3b41aabeb2f83b1e44b314
Autor:
Mohammed R. Alzahrani, Bo-Jhih Guan, Leah L. Zagore, Jing Wu, Chien-Wen Chen, Donny D. Licatalosi, Kristian E. Baker, Maria Hatzoglou
Publikováno v:
PloS one. 17(8)
Endoplasmic Reticulum (ER) stress, caused by the accumulation of misfolded proteins in the ER, elicits a homeostatic mechanism known as the Unfolded Protein Response (UPR). The UPR reprograms gene expression to promote adaptation to chronic ER stress
Publikováno v:
eLife, Vol 9 (2020)
eLife
eLife
Recognition and rapid degradation of mRNA harboring premature translation termination codons (PTCs) serves to protect cells from accumulating non-functional and potentially toxic truncated polypeptides. Targeting of PTC-containing transcripts is medi
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
Nature Communications
Nature Communications
Nonsense-mediated mRNA decay (NMD) represents a eukaryotic quality control pathway that recognizes and rapidly degrades transcripts harbouring nonsense mutations to limit accumulation of non-functional and potentially toxic truncated polypeptides. A
Autor:
Jenna E. Smith, Kristian E. Baker
Publikováno v:
Methods in Molecular Biology ISBN: 9781493972036
RNA binding proteins play critical roles in shaping the complex life cycle of cellular transcripts. For most RNAs, the association with a distinct complement of proteins serves to orchestrate its unique pattern of maturation, localization, translatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caab94ffecdec336de8c4005d3d1218d
https://doi.org/10.1007/978-1-4939-7204-3_15
https://doi.org/10.1007/978-1-4939-7204-3_15
Publikováno v:
Molecular Cell. 45:279-291
Decapping represents a critical control point in regulating expression of protein coding genes. Here, we demonstrate that decapping also modulates expression of long noncoding RNAs (lncRNAs). Specifically, levels of >100 lncRNAs in yeast are controll
Publikováno v:
Nature
The rates of RNA decay and transcription determine the steady-state levels of all messenger RNA and both can be subject to regulation. Although the details of transcriptional regulation are becoming increasingly understood, the mechanism(s) controlli
Publikováno v:
Molecular Cell. 29:134-140
Eukaryotic mRNAs harboring premature translation termination codons are recognized and rapidly degraded by the nonsense-mediated mRNA decay (NMD) pathway. The mechanism for discriminating between mRNAs that terminate translation prematurely and those