Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Kristian E Swearingen"'
Autor:
Kristian E Swearingen, Scott E Lindner, Erika L Flannery, Ashley M Vaughan, Robert D Morrison, Rapatbhorn Patrapuvich, Cristian Koepfli, Ivo Muller, Aaron Jex, Robert L Moritz, Stefan H I Kappe, Jetsumon Sattabongkot, Sebastian A Mikolajczak
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 7, p e0005791 (2017)
Plasmodium falciparum and Plasmodium vivax cause the majority of human malaria cases. Research efforts predominantly focus on P. falciparum because of the clinical severity of infection and associated mortality rates. However, P. vivax malaria affect
Externí odkaz:
https://doaj.org/article/3893574e7ba44319831b3cd61e68b2d9
Autor:
Kristian E Swearingen, Scott E Lindner, Lirong Shi, Melanie J Shears, Anke Harupa, Christine S Hopp, Ashley M Vaughan, Timothy A Springer, Robert L Moritz, Stefan H I Kappe, Photini Sinnis
Publikováno v:
PLoS Pathogens, Vol 12, Iss 4, p e1005606 (2016)
Malaria parasite infection is initiated by the mosquito-transmitted sporozoite stage, a highly motile invasive cell that targets hepatocytes in the liver for infection. A promising approach to developing a malaria vaccine is the use of proteins locat
Externí odkaz:
https://doaj.org/article/36aa7a18455b4b8e8da9ef787afb28cd
Autor:
Scott E. Lindner, Kristian E. Swearingen, Melanie J. Shears, Aswathy Sebastian, Michael P. Walker, Erin N. Vrana, Kevin J. Hart, Allen M. Minns, Istvan Albert, Photini Sinnis, Robert L. Moritz, Stefan H. I. Kappe
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-4 (2022)
Nature Communications
Nature Communications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3acbe9ef26b47b2b85392f7d8a21e2c2
https://doaj.org/article/1ca482631bb9409da5bdd049a070649e
https://doaj.org/article/1ca482631bb9409da5bdd049a070649e
Autor:
Charlie Jennison, Janna M. Gibson, Nina Hertoghs, Dorender A. Dankwa, Sudhir Kumar, Biley A. Abatiyow, Myo Naung, Nana K. Minkah, Kristian E. Swearingen, Robert L. Moritz, Alyssa. E. Barry, Stefan H. I. Kappe, Ashley M. Vaughan
The complex life cycle of Plasmodium parasites, the eukaryotic pathogens that cause malaria, features three distinct invasive forms tailored specifically to the equally distinct host environment they must navigate and invade for progression of the li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c7855884175ba2c85f154c6e820e90b
https://doi.org/10.1101/2022.02.24.481744
https://doi.org/10.1101/2022.02.24.481744
Autor:
Ashley M. Vaughan, Stefan H. I. Kappe, Kayode K. Ojo, Seamus R. Morrone, Meseret Haile, Michael R. Hoopmann, Laura M. Reynolds, Ulrike Kusebauch, Sudhir Kumar, Samantha A. Michaels, Linh T. Tran, Robert L. Moritz, Kristian E. Swearingen
Publikováno v:
mBio, Vol 12, Iss 6 (2021)
mBio
mBio
Gametocytes of the malaria parasite Plasmodium are taken up by the mosquito vector with an infectious blood meal, representing a critical stage for parasite transmission. Calcium-independent protein kinases (CDPKs) play key roles in calcium-mediated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ba81f0974cb95faf9875a8b97679484
https://doi.org/10.1128/mbio.02575-21
https://doi.org/10.1128/mbio.02575-21
Autor:
Michael R. Hoopmann, Seamus R. Morrone, Laura M. Reynolds, Stefan H. I. Kappe, Ashley M. Vaughan, Ulrike Kusebauch, Meseret Haile, Sudhir Kumar, Kayode K. Ojo, Samantha A. Michaels, Linh T. Tran, Robert L. Moritz, Kristian E. Swearingen
Gametocytes of the malaria parasite Plasmodium are taken up by the mosquito vector with an infectious blood meal, representing a critical stage for parasite transmission. Calcium dependent protein kinases (CDPKs) play key roles in calcium-mediated si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d623f0d983041e88ac9f6c50ddf8fa9
https://doi.org/10.1101/2021.06.06.447280
https://doi.org/10.1101/2021.06.06.447280
Autor:
Panga Jaipal Reddy, Santosh Renuse, Satish Mishra, Kristian E. Swearingen, Robert L. Moritz, Raja Sekhar Nirujogi, Photini Sinnis, Akhilesh Pandey, Melanie J. Shears
Publikováno v:
Journal of Proteome Research. 18:3404-3418
The pre-erythrocytic liver stage of the malaria parasite, comprising sporozoites and the liver stages into which they develop, remains one of the least understood parts of the lifecycle, in part owing to the low numbers of parasites. Nonetheless, it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62e3c17c2e6220a1f64d1147aca65fda
https://doi.org/10.1021/acs.jproteome.9b00324
https://doi.org/10.1021/acs.jproteome.9b00324
Autor:
Vladimir Vigdorovich, Eric W. Deutsch, Kristian E. Swearingen, D. Noah Sather, Luis Mendoza, Robert L. Moritz, Jimmy K. Eng, Timothy A. Springer, Stefan H. I. Kappe, David Shteynberg
Publikováno v:
Journal of Proteome Research. 18:652-663
Thrombospondin type 1 repeats (TSRs), small adhesive protein domains with a wide range of functions, are usually modified with O-linked fucose, which may be extended to O-fucose-β1,3-glucose. Collision-induced dissociation (CID) spectra of O-fucosyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f586686b7d975fc26df694ec00437138
https://doi.org/10.1021/acs.jproteome.8b00638
https://doi.org/10.1021/acs.jproteome.8b00638
Autor:
Helen Thomas, Will Betz, Robert L. Moritz, Bridget S. Fisher, Jim Freeth, Sara Carbonetti, Debashree Goswami, Jo Soden, Vladimir Vigdorovich, Thao Nguyen, Kristian E. Swearingen, Nicholas Dambrauskas, Brandon K. Wilder, Ryan W.J. Steel, Sudhir Kumar, Nelly Camargo, D. Noah Sather, Silvia A. Arredondo, Stefan H. I. Kappe
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Following their inoculation by the bite of an infected Anopheles mosquito, the malaria parasite sporozoite forms travel from the bite site in the skin into the bloodstream, which transports them to the liver. The thrombospondin-related anonymous prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6fac39457570a01ea2751bb26beac1f
https://doi.org/10.1038/s41598-021-90722-5
https://doi.org/10.1038/s41598-021-90722-5
Autor:
Scott E. Lindner, Kevin J. Hart, Melanie J. Shears, Michael P. Walker, Erin N. Vrana, Allen M. Minns, Robert L. Moritz, Stefan H. I. Kappe, Kristian E. Swearingen, Photini Sinnis
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Nature Communications
Plasmodium sporozoites are transmitted from infected mosquitoes to mammals, and must navigate the host skin and vasculature to infect the liver. This journey requires distinct proteomes. Here, we report the dynamic transcriptomes and proteomes of bot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fd87f4b33dab7069c38d505b6b33afd
https://doi.org/10.1038/s41467-019-12936-6
https://doi.org/10.1038/s41467-019-12936-6