Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Kristian Daniel Ralph Roth"'
Autor:
Federico Bertoglio, Doris Meier, Nora Langreder, Stephan Steinke, Ulfert Rand, Luca Simonelli, Philip Alexander Heine, Rico Ballmann, Kai-Thomas Schneider, Kristian Daniel Ralph Roth, Maximilian Ruschig, Peggy Riese, Kathrin Eschke, Yeonsu Kim, Dorina Schäckermann, Mattia Pedotti, Philipp Kuhn, Susanne Zock-Emmenthal, Johannes Wöhrle, Normann Kilb, Tobias Herz, Marlies Becker, Martina Grasshoff, Esther Veronika Wenzel, Giulio Russo, Andrea Kröger, Linda Brunotte, Stephan Ludwig, Viola Fühner, Stefan Daniel Krämer, Stefan Dübel, Luca Varani, Günter Roth, Luka Čičin-Šain, Maren Schubert, Michael Hust
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Antibodies targeting the spike protein of coronaviruses are potential candidates for therapeutic development. Here, Bertoglio et al. use phage display to select anti-SARS-CoV-2 spike antibodies from the human naïve universal antibody gene libraries
Externí odkaz:
https://doaj.org/article/0dc5d5dbf361487e9f729846cf72c808
Autor:
Tom Pieper, Kristian Daniel Ralph Roth, Viktor Glaser, Tobias Riet, Laura Elisa Buitrago-Molina, Maike Hagedorn, Maren Lieber, Michael Hust, Fatih Noyan, Elmar Jaeckel, Matthias Hardtke-Wolenski
Publikováno v:
Cells, Vol 12, Iss 11, p 1453 (2023)
Adoptive transfer of antigen-specific regulatory T cells (Tregs) has shown promising results in the treatment of autoimmune diseases; however, the use of polyspecific Tregs has limited effects. However, obtaining a sufficient number of antigen-specif
Externí odkaz:
https://doaj.org/article/2290f40ad4254c9d8cd3659fc1a59533
Autor:
Janin Korn, Dorina Schäckermann, Toni Kirmann, Federico Bertoglio, Stephan Steinke, Janyn Heisig, Maximilian Ruschig, Gertrudis Rojas, Nora Langreder, Esther Veronika Wenzel, Kristian Daniel Ralph Roth, Marlies Becker, Doris Meier, Joop van den Heuvel, Michael Hust, Stefan Dübel, Maren Schubert
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Abstract Antibodies are essential tools for therapy and diagnostics. Yet, production remains expensive as it is mostly done in mammalian expression systems. As most therapeutic IgG require mammalian glycosylation to interact with the human immune sys
Externí odkaz:
https://doaj.org/article/58d50e96dc5f45bcb3f271b3937cc6e0
Autor:
Kristian Daniel Ralph Roth, Esther Veronika Wenzel, Maximilian Ruschig, Stephan Steinke, Nora Langreder, Philip Alexander Heine, Kai-Thomas Schneider, Rico Ballmann, Viola Fühner, Philipp Kuhn, Thomas Schirrmann, André Frenzel, Stefan Dübel, Maren Schubert, Gustavo Marçal Schmidt Garcia Moreira, Federico Bertoglio, Giulio Russo, Michael Hust
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Antibodies are essential molecules for diagnosis and treatment of diseases caused by pathogens and their toxins. Antibodies were integrated in our medical repertoire against infectious diseases more than hundred years ago by using animal sera to trea
Externí odkaz:
https://doaj.org/article/a209cfb24a6a400db098fc0eff68beaa
Autor:
Federico Bertoglio, Viola Fühner, Maximilian Ruschig, Philip Alexander Heine, Leila Abassi, Thomas Klünemann, Ulfert Rand, Doris Meier, Nora Langreder, Stephan Steinke, Rico Ballmann, Kai-Thomas Schneider, Kristian Daniel Ralph Roth, Philipp Kuhn, Peggy Riese, Dorina Schäckermann, Janin Korn, Allan Koch, M. Zeeshan Chaudhry, Kathrin Eschke, Yeonsu Kim, Susanne Zock-Emmenthal, Marlies Becker, Margitta Scholz, Gustavo Marçal Schmidt Garcia Moreira, Esther Veronika Wenzel, Giulio Russo, Hendrikus S.P. Garritsen, Sebastian Casu, Andreas Gerstner, Günter Roth, Julia Adler, Jakob Trimpert, Andreas Hermann, Thomas Schirrmann, Stefan Dübel, André Frenzel, Joop Van den Heuvel, Luka Čičin-Šain, Maren Schubert, Michael Hust
Publikováno v:
Cell Reports, Vol 36, Iss 4, Pp 109433- (2021)
Summary: The novel betacoronavirus severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) causes a form of severe pneumonia disease called coronavirus disease 2019 (COVID-19). To develop human neutralizing anti-SARS-CoV-2 antibodies, antibody g
Externí odkaz:
https://doaj.org/article/9c2876f60a3849cc9e53afa0c2d3362e
Autor:
Traud Winkelmann, Michael Hust, Thomas Reinard, Kristian Daniel Ralph Roth, Dingbo Zhang, Juvenal Assou, Jens Boch, Stephan Steinke
Publikováno v:
The plant journal 109 (2022), Nr. 3
The plant journal
The plant journal
Food allergies are a major health issue worldwide. Modern breeding techniques such as genome editing via CRISPR/Cas9 have the potential to mitigate this by targeting allergens in plants. This study addressed the major allergen Bra j I, a seed storage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::302ce49e2ad316900b03ff2c3b6f1844
https://pubmed.ncbi.nlm.nih.gov/34784073
https://pubmed.ncbi.nlm.nih.gov/34784073
Autor:
Kristian Daniel Ralph Roth, Janyn Heisig, Joop van den Heuvel, Michael Hust, Marlies Becker, Maximilian Ruschig, Maren Schubert, Gertrudis Rojas, Stefan Dübel, Dorina Schäckermann, Janin Korn, Esther Veronika Wenzel, Federico Bertoglio, Doris Meier, Nora Langreder, Stephan Steinke, Toni Kirmann
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific reports, 10, Article number: 21393 (2020), DOI 10.1038/s41598-020-78425-9--Sci Rep--http://www.bibliothek.uni-regensburg.de/ezeit/?2615211--https://www.nature.com/srep/--2045-2322--2045-2322
Scientific reports
England
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific reports, 10, Article number: 21393 (2020), DOI 10.1038/s41598-020-78425-9--Sci Rep--http://www.bibliothek.uni-regensburg.de/ezeit/?2615211--https://www.nature.com/srep/--2045-2322--2045-2322
Scientific reports
England
Mammalian cells are the most commonly used production system for therapeutic antibodies. Protocols for the expression of recombinant antibodies in HEK293-6E cells in different antibody formats are described in detail. As model, antibodies against Kal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ee64b7c5f207937171699a496dee03a
Autor:
Sebastian Casu, Federico Bertoglio, Kristian Daniel Ralph Roth, Maren Schubert, Peggy Riese, Stephan Steinke, André Frenzel, Yeonsu Kim, Margitta Scholz, Michael Hust, Hendrikus S.P. Garritsen, Allan Koch, Thomas Schirrmann, Maximilian Ruschig, Rico Ballmann, Stefan Dübel, Günter Roth, Dorina Schäckermann, Giulio Russo, Ulfert Rand, Thomas Klünemann, Marlies Becker, Gustavo Marçal Schmidt Garcia Moreira, Philipp Kuhn, Janin Korn, Philip Alexander Heine, Doris Meier, Luka Cicin-Sain, Nora Langreder, Esther Veronika Wenzel, Kathrin Eschke, Andreas Gerstner, Viola Fühner, Julia Adler, Andreas Hermann, Susanne Zock-Emmenthal, Leila Abasi, Joop van den Heuvel, Jakob Trimpert, Kai-Thomas Schneider, M. Zeeshan Chaudhry
The novel betacoranavirus SARS-CoV-2 causes a form of severe pneumonia disease, termed COVID-19 (coronavirus disease 2019). Recombinant human antibodies are proven potent neutralizers of viruses and can block the interaction of viral surface proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d0ea4e53163c64198aa669c61357674
https://doi.org/10.1101/2020.12.03.409318
https://doi.org/10.1101/2020.12.03.409318
Autor:
Saskia Helmsing, Esther Veronika Wenzel, Michael Hust, Kristian Daniel Ralph Roth, André Frenzel, Viola Fühner, Giulio Russo
Publikováno v:
Methods in Molecular Biology ISBN: 9781493998524
Antibody phage display is the most used in vitro technology to generate recombinant, mainly human, antibodies as tools for research, for diagnostic assays, and for therapeutics. Up to now (autumn 2018), eleven FDA/EMA-approved therapeutic antibodies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ceca7d9a4c0b9b471d60d2abba05793
https://doi.org/10.1007/978-1-4939-9853-1_8
https://doi.org/10.1007/978-1-4939-9853-1_8
Autor:
Philip Alexander Heine, Giulio Russo, Viola Fühner, Kristian Daniel Ralph Roth, Michael Hust, Gustavo Marçal Schmidt Garcia Moreira, Doris Meier, Kilian Johannes Carl Zilkens
Publikováno v:
Methods in Molecular Biology ISBN: 9781493989577
Antibodies are widely used in a large variety of research applications, for diagnostics and therapy of numerous diseases, primarily cancer and autoimmune diseases. Antibodies are binding specifically to target structures (antigens). The antigen-bindi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3efb01c4083d5e0e4e912f8d20a4e762
https://doi.org/10.1007/978-1-4939-8958-4_17
https://doi.org/10.1007/978-1-4939-8958-4_17