Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Kristi Rothermund"'
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
A major challenge in regenerating periodontal tissues is emulating its complex structure containing both mineralized and soft tissues. In this study, scaffold-free tissue constructs engineered using periodontal ligament cells (PDLCs), which contain a
Externí odkaz:
https://doaj.org/article/f71dbbe1777b4d6489df565575cd0ee6
Autor:
J Anthony Graves, Yudong Wang, Sunder Sims-Lucas, Edward Cherok, Kristi Rothermund, Maria F Branca, Jennifer Elster, Donna Beer-Stolz, Bennett Van Houten, Jerry Vockley, Edward V Prochownik
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37699 (2012)
Although the c-Myc (Myc) oncoprotein controls mitochondrial biogenesis and multiple enzymes involved in oxidative phosphorylation (OXPHOS), the coordination of these events and the mechanistic underpinnings of their regulation remain largely unexplor
Externí odkaz:
https://doaj.org/article/0d1be3b02bfb4271b501c310e31c86fc
Autor:
J Anthony Graves, Kristi Rothermund, Tao Wang, Wei Qian, Bennett Van Houten, Edward V Prochownik
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e13717 (2010)
Deregulation of c-Myc (Myc) occurs in many cancers. In addition to transforming various cell types, Myc also influences additional transformation-associated cellular phenotypes including proliferation, survival, genomic instability, reactive oxygen s
Externí odkaz:
https://doaj.org/article/845ac7bd31234c878d64ae44e7c85b3f
Autor:
Michelle D. Drewry, Matthew T. Dailey, Kristi Rothermund, Charles Backman, Kris N. Dahl, Fatima N. Syed-Picard
Publikováno v:
ACS Biomaterials Science & Engineering. 8:814-825
Current treatments of facial nerve injury result in poor functional outcomes due to slow and inefficient axon regeneration and aberrant reinnervation. To address these clinical challenges, bioactive scaffold-free cell sheets were engineered using neu
Publikováno v:
Journal of Oral and Maxillofacial Surgery. 76:e74
Autor:
Edward V. Prochownik, Susan M. Sereika, Nadja de Souza-Pinto, Kristi Rothermund, Pawel Jaruga, Elaine Fernandes, Rachel A. Egler, Miral Dizdaroglu
Publikováno v:
Oncogene. 24:8038-8050
Overexpression of c-Myc results in transformation and multiple other phenotypes, and is accompanied by the deregulation of a large number of target genes. We previously demonstrated that peroxiredoxin 1 (Prdx1), a scavenger of reactive oxygen species
Autor:
Eric S. Goetzman, Edward V. Prochownik, Yudong Wang, Donna Beer-Stolz, J. Anthony Graves, Jie Lu, B E Van Houten, Kristi Rothermund, M Sarin, Sunder Sims-Lucas, Yuxun Zhang, F Zhang, Jerry Vockley
Publikováno v:
Cell Death & Disease
The c-Myc (Myc) oncoprotein regulates numerous phenotypes pertaining to cell mass, survival and metabolism. Glycolysis, oxidative phosphorylation (OXPHOS) and mitochondrial biogenesis are positively controlled by Myc, with myc−/− rat fibroblasts
Autor:
Edward V. Prochownik, John S. Lazo, Yves Pommier, Kristi Rothermund, Sajithlal B. Gangadharan, Fang Zhang
Publikováno v:
Oncotarget
Cancer stem cells (CSCs) are a subpopulation generally thought to be responsible for cancer initiation and progression. Because CSCs are often rare in the total tumor cell population and differentiate rapidly when grown in culture, it has been challe
Autor:
Kristi Rothermund, Donald K. Scott, Mallikarjuna R. Metukuri, Edward V. Prochownik, J. Anthony Graves
Peroxiredoxins (Prxs) are highly conserved proteins found in most organisms, where they function primarily to scavenge reactive oxygen species (ROS). Loss of the most ubiquitous member of the family, Prx1, is associated with the accumulation of oxida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fe87b10b5c4933e3156ca4ca2753cda
https://europepmc.org/articles/PMC2649099/
https://europepmc.org/articles/PMC2649099/
Autor:
Seth J. Corey, Lars Kjeldsen, Jero Calafat, Lene Udby, Josh Lovelock, Zeljka Korade Mirnics, Niels Borregaard, Sangram S. Sisodia, Kristi Rothermund
Publikováno v:
Blood cells, moleculesdiseases. 28(1)
ABSTRACT Most cases of familial Alzheimer disease (AD) are caused by mutations in presenilin 1 (PS1) and presenilin 2 (PS2). Presenilins are required for the proteolytic processing of the β amyloid precursor protein, which yields amyloid β peptide,