Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Kristi R Chakrabarti"'
Activation of the unfolded protein response in sarcoma cells treated with rapamycin or temsirolimus.
Autor:
Joseph W Briggs, Ling Ren, Kristi R Chakrabarti, Yien Che Tsai, Allan M Weissman, Ryan J Hansen, Daniel L Gustafson, Yousuf A Khan, Jonathan D Dinman, Chand Khanna
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0185089 (2017)
Activation of the unfolded protein response (UPR) in eukaryotic cells represents an evolutionarily conserved response to physiological stress. Here, we report that the mTOR inhibitors rapamycin (sirolimus) and structurally related temsirolimus are ca
Externí odkaz:
https://doaj.org/article/21191385288e488bb0ace408ca335cc3
Autor:
Lewis A. Chodosh, Jason R. Ruth, James V. Alvarez, Kristi R. Chakrabarti, Dhruv K. Pant, Tien-Chi Pan, Yi Feng
PDF file 645K, This file contains supplemental figures that provided supportive evidence to the main conclusion described in the manuscript
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3be234b4705a0e95b5ea63d84ecef1e5
https://doi.org/10.1158/2159-8290.22530752.v1
https://doi.org/10.1158/2159-8290.22530752.v1
Autor:
Lewis A. Chodosh, Jason R. Ruth, James V. Alvarez, Kristi R. Chakrabarti, Dhruv K. Pant, Tien-Chi Pan, Yi Feng
PDF file 70K, This file contains detailed information about the experimental procedures and the reagents used in the assays described in the manuscript
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60cec2c4e129f7268b9fd9b2370796bb
https://doi.org/10.1158/2159-8290.22530749.v1
https://doi.org/10.1158/2159-8290.22530749.v1
Autor:
Lewis A. Chodosh, Jason R. Ruth, James V. Alvarez, Kristi R. Chakrabarti, Dhruv K. Pant, Tien-Chi Pan, Yi Feng
PDF file 49K, This file contains text descriptions for each corresponding supplemental figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b51e7521c76029a7d2b1ea7bc57af56
https://doi.org/10.1158/2159-8290.22530755.v1
https://doi.org/10.1158/2159-8290.22530755.v1
Autor:
Keyata N. Thompson, Julia A. Ju, Eleanor C. Ory, Stephen J. P. Pratt, Rachel M. Lee, Trevor J. Mathias, Katarina T. Chang, Cornell J. Lee, Olga G. Goloubeva, Patrick C. Bailey, Kristi R. Chakrabarti, Christopher M. Jewell, Michele I. Vitolo, Stuart S. Martin
Publikováno v:
Breast Cancer Research. 24
Clinical cancer imaging focuses on tumor growth rather than metastatic phenotypes. The microtubule-depolymerizing drug, Vinorelbine, reduced the metastatic phenotypes of microtentacles, reattachment and tumor cell clustering more than tumor cell viab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ba36eb3f32e15d9c1628775b302d634
https://doi.org/10.1186/s13058-022-01506-2
https://doi.org/10.1186/s13058-022-01506-2
Autor:
Christopher M. Jewell, Kristi R. Chakrabarti, Rachel M. Lee, Cornell J. Lee, Trevor J. Mathias, Olga Goloubeva, Stephen Pratt, Stuart S. Martin, Michele Vitolo, Julia A. Ju, Patrick C. Bailey, Keyata Thompson, Eleanor C Ory
Background: Clinical breast cancer imaging inevitably focuses on tumor growth rather than the metastatic dissemination that is a greater challenge for patient survival. Emerging preclinical evidence indicates that chemotherapy can elevate levels of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::173bb163aba36befe813b0cf3fd8687d
https://doi.org/10.21203/rs.3.rs-127507/v1
https://doi.org/10.21203/rs.3.rs-127507/v1
Autor:
Rachel M. Lee, Patrick C. Bailey, Keyata Thompson, Kristi R. Chakrabarti, Michele Vitolo, Eleanor C Ory, Cornell J. Lee, Stuart S. Martin, Stephen J.P. Pratt
Publikováno v:
iScience, Vol 8, Iss, Pp 29-39 (2018)
iScience
iScience
Summary The mammosphere assay has become widely employed to quantify stem-like cells in a population. However, the problem is there is no standard protocol employed by the field. Cell seeding densities of 1,000 to 100,000 cells/mL have been reported.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::254e16999f8b735ab20852948b0cc030
https://doi.org/10.1016/j.isci.2018.08.015
https://doi.org/10.1016/j.isci.2018.08.015
Autor:
Wolfgang Losert, Kristi R. Chakrabarti, Christopher M. Jewell, James I. Andorko, Desu Chen, Stuart S. Martin, Peipei Zhang, Eleanor C Ory
Publikováno v:
Oncotarget
During metastasis, tumor cells dynamically change their cytoskeleton to traverse through a variety of non-adherent microenvironments, including the vasculature or lymphatics. Due to the challenges of imaging drift in non-adhered tumor cells, the dyna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9280491cc4ba54e919e18a7209d35a60
https://doi.org/10.18632/oncotarget.22874
https://doi.org/10.18632/oncotarget.22874
Autor:
Michael M. Lipsky, Keyata Thompson, Kristi R. Chakrabarti, Monica S. Charpentier, Jennifer R. Yoon, Amanda E. Boggs, Lekhana Bhandary, Lindsay K. Hessler, Michele Vitolo, Rebecca A. Whipple, Stuart S. Martin
Publikováno v:
Oncotarget
A high proportion of human tumors maintain activation of both the PI3K and Ras/MAPK pathways. In basal-like breast cancer (BBC), PTEN expression is decreased/lost in over 50% of cases, leading to aberrant activation of the PI3K pathway. Additionally,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8bd39498fc52de4b750a3c74ebe9114
https://doi.org/10.18632/oncotarget.6159
https://doi.org/10.18632/oncotarget.6159
Autor:
Keyata Thompson, Kristi R. Chakrabarti, Lekhana Bhandary, Michele Vitolo, Amanda E. Boggs, Lindsay K. Hessler, Stuart S. Martin, Rebecca A. Whipple
Publikováno v:
Oncotarget
The presence of tumor cells in the circulation is associated with a higher risk of metastasis in patients with breast cancer. Circulating breast tumor cells use tubulin-based structures known as microtentacles (McTNs) to re-attach to endothelial cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b359cbb0113ec503b7dbdc4b4c5408e8
http://europepmc.org/articles/PMC4742178
http://europepmc.org/articles/PMC4742178