Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Kristi Muldoon-Jacobs"'
Autor:
Jason K. Dietz, Kristi Muldoon-Jacobs
Publikováno v:
Frontiers in Sustainable Food Systems, Vol 8 (2024)
Developers are looking for new ways to produce proteins and other substances for food, pharmaceutical and industrial use by genetically engineering food crops to produce the desired substance of interest (i.e., molecular farming). Developers should b
Externí odkaz:
https://doaj.org/article/071adbdf35c34a7a98aab08ff0091a33
Publikováno v:
International Journal of Biological Sciences, Vol 4, Iss 5, Pp 291-299 (2008)
Cellular longevity is a complex process relevant to age-related diseases including but not limited to chronic illness such as diabetes and metabolic syndromes. Two gene families have been shown to play a role in the genetic regulation of longevity; t
Externí odkaz:
https://doaj.org/article/7a77212e33ef4528a0d7f6334e6ca910
Publikováno v:
Clinical pharmacology and therapeutics. 104(3)
The United States Pharmacopeia (USP) is an independent, nonprofit, science-based organization whose mission is to improve global health through public quality standards for dietary supplements, medicines, and food ingredients.1 Before developing stan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34f92ff13cab8ad7a808019c8431e96f
https://pubmed.ncbi.nlm.nih.gov/30066384
https://pubmed.ncbi.nlm.nih.gov/30066384
Publikováno v:
Food and Chemical Toxicology. 59:187-190
The mouse lymphoma L5178Y Tk(+/-) assay is broadly used in toxicology to assess genotoxicity because of its known sensitivity to genotoxicants that act through a variety of mechanisms, which may include epigenetic DNA methylation. This brief article
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9506c2989a4dc71f88f887583341e49
https://doi.org/10.1016/j.fct.2013.06.007
https://doi.org/10.1016/j.fct.2013.06.007
Publikováno v:
Journal of Applied Toxicology. 32:643-653
The term epigenetics was coined in the context of developmental studies, but the meaning of the term has evolved over time. Epigenetic modulators of gene expression are now known to include DNA methylation, chromatin modifications and noncoding RNAs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de1d8b2205a5c60da99d09a176f93f30
https://doi.org/10.1002/jat.2717
https://doi.org/10.1002/jat.2717
Publikováno v:
Expert Opinion on Drug Metabolism & Toxicology. 6:793-796
Over 10 years ago, the Office of Food Additive Safety (OFAS) in the FDA's Center for Food Safety and Applied Nutrition implemented the formal use of structure-activity relationship analysis and quantitative structure-activity relationship (QSAR) anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b4bee21ec90f58e55865180ca86099a
https://doi.org/10.1517/17425255.2010.493555
https://doi.org/10.1517/17425255.2010.493555
Autor:
Douglas R. Spitz, Nukhet Aykin-Burns, Hyun-Seok Kim, Chu-Xia Deng, Kheem S. Bisht, Athanassios Vassilopoulos, Kristi Muldoon-Jacobs, Krish Patel, Kjerstin M. Owens, Sarki A. Abdulkadir, Phuongmai Nguyen, Keshav K. Singh, David Gius, Seong Hoon Park, Özkan Özden, Jason E. Savage, Riet van der Meer, J. Daniel Pennington
Publikováno v:
Cancer Cell. 17:41-52
The sirtuin gene family (SIRT) is hypothesized to regulate the aging process and play a role in cellular repair. This work demonstrates that SIRT3(-/-) mouse embryonic fibroblasts (MEFs) exhibit abnormal mitochondrial physiology as well as increases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebffb9e2d01b69043779f702e29d3c96
https://doi.org/10.1016/j.ccr.2009.11.023
https://doi.org/10.1016/j.ccr.2009.11.023
Autor:
Jaime Leclerc, Mark Mishra, Lunching Sun, Nukhet Aykin-Burns, Kheem S. Bisht, Phuongmai Nguyen, J. Daniel Pennington, Douglas R. Spitz, David Gius, Hyun-Seok Kim, Bong Hyun Ahn, Chu-Xia Deng, Kristi Muldoon Jacobs
Publikováno v:
International Journal of Biological Sciences
Cellular longevity is a complex process relevant to age-related diseases including but not limited to chronic illness such as diabetes and metabolic syndromes. Two gene families have been shown to play a role in the genetic regulation of longevity; t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9954de794e4cd079ab5177b6baf65b98
https://doi.org/10.7150/ijbs.4.291
https://doi.org/10.7150/ijbs.4.291
Autor:
David Gius, Gil Bar-Sela, Mark Mishra, Kristi Muldoon Jacobs, Lunching Sun, J. Daniel Pennington
Publikováno v:
Current Pharmaceutical Design. 13:3368-3377
Tumor cell proliferation, de-differentiation, and progression depend on a complex combination of altered intracellular processes including cell cycle regulation, excessive growth factor pathway activation, and decreased apoptosis. Metabolites from th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a01bd69edb1eb70f96f868b818e28314
https://doi.org/10.2174/138161207782360537
https://doi.org/10.2174/138161207782360537
Publikováno v:
The Cancer Journal. 13:65-69
It now appears that epigenetics plays a central role in transformation, both in vitro and in vivo. The expression and regulation of DNA methylation and the subsequent chromatin structure are significantly altered in tumor cells, suggesting a direct r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5513ac451daab3b30196a4f2f1e605dc
https://doi.org/10.1097/ppo.0b013e31803c7565
https://doi.org/10.1097/ppo.0b013e31803c7565