Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Kristi Mahadocon"'
Autor:
Ashraf Badros, R. Donald Harvey, Rong Chen, Tianling Chen, Kristi Mahadocon, Judith A. Fox, Rajni Sinha, David A. Siegel, Wei Gang Tong, William G. Wierda, Peggy Kegley, William Plunkett, Ute Hoch, Steven Coutre, Leslie Popplewell
Publikováno v:
Journal of Clinical Oncology. 28:3015-3022
Purpose SNS-032 is a highly selective and potent inhibitor of cyclin-dependent kinases (Cdks) 2, 7, and 9, with in vitro growth inhibitory effects and ability to induce apoptosis in malignant B cells. A phase I dose-escalation study of SNS-032 was co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd8981c13073e88950685fb01f3fbf61
https://doi.org/10.1200/jco.2009.26.1347
https://doi.org/10.1200/jco.2009.26.1347
Autor:
Tianling Chen, Maureen Cooper, Shaker R. Dakhil, Michael B. Maris, Francesco Turturro, Richard Stone, Judith A. Fox, Glenn Michelson, Kristi Mahadocon, Craig J. Berman, Robert K. Stuart, Hagop M. Kantarjian, Farhad Ravandi, Larry D. Cripe
Publikováno v:
Blood. 114:1037-1037
Abstract 1037 Poster Board I-59 Background: Voreloxin is a first-in-class anticancer quinolone derivative (AQD) that intercalates DNA and inhibits topoisomerase II, inducing apoptosis. Interim results of REVEAL-1, a Phase 2 (Ph 2) dose regimen optimi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ef0af404fbf7e3ac817cc5c97b75573
https://doi.org/10.1182/blood.v114.22.1037.1037
https://doi.org/10.1182/blood.v114.22.1037.1037
Autor:
Kristi Mahadocon, Steven Coutre, Mary G. Bolton, Peggy Kegley, R. Donald Harvey, David S. Siegel, William Plunkett, Rajni Sinha, Judith A. Fox, Runzhe Chen, Leslie Popplewell, William G. Wierda, Ashraf Badros
Publikováno v:
Blood. 112:3178-3178
SNS-032, formerly BMS-387032, is a highly selective and potent inhibitor of cyclin-dependent kinases (CDK) 2, 7 and 9. CDK2 and CDK7 are involved in cell cycle regulation. CDK7, along with CDK9, regulate RNA polymerase (Pol) II-dependent transcriptio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::534f9d6b074a4682f05410ac4232eca7
https://doi.org/10.1182/blood.v112.11.3178.3178
https://doi.org/10.1182/blood.v112.11.3178.3178