Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kristi L Norris"'
Autor:
Chao‐Chieh Lin, Jin Yan, Meghan D Kapur, Kristi L Norris, Cheng‐Wei Hsieh, De Huang, Nicolas Vitale, Kah‐Leong Lim, Ziqiang Guan, Xiao‐Fan Wang, Jen‐Tsan Chi, Wei‐Yuan Yang, Tso‐Pang Yao
Publikováno v:
EMBO reports. 23
Autophagy has emerged as the prime machinery for implementing organelle quality control. In the context of mitophagy, the ubiquitin E3 ligase Parkin tags impaired mitochondria with ubiquitin to activate autophagic degradation. Although ubiquitination
Autor:
Jen-Tsan Chi, Nicolas Vitale, Cheng-Wei Hsieh, Meghan Kapur, Ziqiang Guan, Jin Yan, Chao-Chieh Lin, Kristi L. Norris, Wei-Yuan Yang, Chun-Hsiang Lai, Tso-Pang Yao, Kah-Leong Lim
Mitochondrial failure caused by Parkin mutations contributes to Parkinson’s disease. Parkin binds, ubiquitinates, and targets impaired mitochondria for autophagic destruction. Robust mitophagy involves peri-nuclear concentration of Parkin-tagged mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bc4a2bac374fd8bc46b7e906e3f40c2
Autor:
Richard J. Youle, Kristi L. Norris, Junhe Ma, Guillermo A. Bermejo, Nico Tjandra, Frank Edlich
Publikováno v:
Proceedings of the National Academy of Sciences. 109:20901-20906
The human protein Bax sits at a critical regulatory junction of apoptosis, or programmed cell death. Bax exists in equilibrium between cytosolic and mitochondria-associated forms that shifts toward the latter when Bax is activated by proapoptotic pro
Autor:
Tso-Pang Yao, Kristi L. Norris
Publikováno v:
Essays in Biochemistry. 52:65-77
Nutrient deprivation or cellular stress leads to the activation of a catabolic pathway that is conserved across species, known as autophagy. This process is considered to be adaptive and plays an important role in a number of cellular processes, incl
Autor:
Iain Scott, Kristi L. Norris
Publikováno v:
Biochemical and Biophysical Research Communications. 375:101-106
Apoptosis of virus-infected cells is one important host strategy used to limit viral infection. Recently a member of the innate immune signaling pathway, MAVS, was localized to mitochondria, an organelle important for apoptosis regulation. Here we in
Autor:
Richard J. Youle, Kristi L. Norris
Publikováno v:
Journal of Virology. 82:6232-6243
Apoptosis is a host defense mechanism against viruses that can be subverted by viral gene products. Human cytomegalovirus encodes viral mitochondria-localized inhibitor of apoptosis (vMIA; also known as pUL37x1), which is targeted to mitochondria and
Autor:
Kristi L. Norris, David H. Holman, Jacek Bielawski, James S. Norris, Youssef H. Zeidan, Saeed Elojeimy, Xiang Liu, Lorianne S. Turner, Zdzislaw M. Szulc, Ahmed El-Zawahry, Yusuf A. Hannun, Alicja Bielawska
Publikováno v:
Cancer Chemotherapy and Pharmacology. 61:231-242
Alterations in ceramide metabolism have been reported in prostate cancer (PCa), resulting in escape of cancer cells from ceramide-induced apoptosis. Specifically, increased expression of lysosomal acid ceramidase (AC) has been shown in some primary P
Autor:
J. Paul Taylor, Peter J. Shaughnessy, Kah-Leong Lim, Anna E. West, Tso-Pang Yao, Rui Hao, Meghan Kapur, Dennis Chou, Simone Engelender, Chun-Hsiang Lai, Kristi L. Norris, Jin Yan, Liang-Fu Chen
Mutations in PARKIN (PARK2), an ubiquitin ligase, cause early onset Parkinson disease. Parkin was shown to bind, ubiquitinate, and target depolarized mitochondria for destruction by autophagy. This process, mitophagy, is considered crucial for mainta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0897be5e65a41422ca3c83e89ecf7100
https://europepmc.org/articles/PMC4447961/
https://europepmc.org/articles/PMC4447961/
Autor:
David H. Holman, Jian-Yun Dong, Thomas E. Keane, James S. Norris, Ahmed El-Zawahry, Mahvash Tavassoli, Kristi L. Norris
Publikováno v:
Future Oncology. 1:115-123
Gene therapy has been in a continuous evolutionary process since the first approved trial occurred in 1990 at the National Institute of Health. In the USA, as of March 2004, there were 619 approved gene therapy/transfer protocols and 405 of these wer
Autor:
Richard J. Youle, Albert Neutzner, Charles Hemion, Melanie Neutzner, Anne-Sophie Benischke, Mariusz Karbowski, Kristi L. Norris, Stefan Frank
Publikováno v:
The FASEB Journal. 26