Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Kristi Daris"'
Autor:
Luis Diaz, Natalia Gomez, Fang Lu, Kristi Daris, Neeraj Jagdish Agrawal, Richele Bruno, Agatha Wieczorek
Publikováno v:
Biotechnology and Bioengineering. 115:2930-2940
Therapeutic bispecific antibodies are formed by assembly of multichain polypeptides. In general, a bispecific antibody has two different light chains and two different heavy chains that fold and correctly pair via engineered interchain interactions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11931bcd6c289e889f35a349d1b41c97
https://doi.org/10.1002/bit.26803
https://doi.org/10.1002/bit.26803
Publikováno v:
Biotechnology Journal. 15:1900289
Mammalian cell banks for biopharmaceutical production are usually derived from a single progenitor cell. Different methods to estimate the probability that the cell banks are clonally derived, or the probability of clonality (PoC), associated with va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff90937d813244d466afbe658d10a312
https://doi.org/10.1002/biot.201900289
https://doi.org/10.1002/biot.201900289
Autor:
Kristi Daris, Tharmala Tharmalingam, Pheng Yam, Nicole Tejeda, Sam Yaghmour, Fang Lu, Jennitte Stevens, Chetan T. Goudar, Hedieh Barkhordarian, Trent P. Munro
Publikováno v:
Biotechnology Progress
Regulatory guidelines require the sponsors to provide assurance of clonality of the production cell line, and when such evidence is not available, additional studies are typically required to further ensure consistent long-term manufacturing of the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a33d0562eace6e57e2d12e7153fb05e
https://pubmed.ncbi.nlm.nih.gov/29882350
https://pubmed.ncbi.nlm.nih.gov/29882350
Publikováno v:
Biotechnology progress. 34(3)
Monoclonal antibodies (mAbs) are composed of two heavy chain (HC) and two light chain (LC) polypeptides. The proper folding and assembly of HC and LC is critical for antibody production. Current dogma indicates that the free HCs are retained in the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab344cd8a36e2348a590f6c5632acc42
https://pubmed.ncbi.nlm.nih.gov/29341500
https://pubmed.ncbi.nlm.nih.gov/29341500
Autor:
Lynette Buck, Atim A. Enyenihi, Kristi Daris, Roman A. Zubarev, Sohye Kang, Gang Xiao, Pavel V. Bondarenko, Da Ren, Rohini Deshpande
Publikováno v:
Biotechnology and Bioengineering. 111:748-760
Mammalian cell culture performance is influenced by both intrinsic (genetic) and extrinsic (media and process) factors. In this study, intrinsic capacity of various monoclonal antibody-producing Chinese Hamster Ovary (CHO) cell lines was compared by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::817b0f87858a2895c3c0a31ce890673e
https://doi.org/10.1002/bit.25141
https://doi.org/10.1002/bit.25141
Autor:
William G. Richards, Ji Li, Frank Asuncion, Shirley Steavenson, Qing-Tian Niu, Kristi Daris, Tom Horan, Barbara Tipton, Mario Grisanti, Edward Lee, Mark Daris, Eliane G. Valente, Philip Babij, Hong-Lin Tan, Wei Fan, Chun-Ya Han, Hossein Salimi-Moosavi, Denise Dwyer, Paul J. Kostenuik, Zhaopo Geng, Mauricio Barrero, Hsieng Sen Lu, David L. Lacey, Marina Stolina, W. Scott Simonet, Frederick W. Jacobsen, Jackie Sheng, Rohini Deshpande, Pam Kurimoto, Aaron George Winters, Chaoyang Li, Xiaodong Li, Min Liu, Michael S. Ominsky, Longchuan Yu, Jae Lee, Hua Zhu Ke, Raj Haldankar, Qing Chen, Jennifer Lavallee
Publikováno v:
Journal of Bone and Mineral Research. 26:2610-2621
The physiological role of Dickkopf-1 (Dkk1) during postnatal bone growth in rodents and in adult rodents was examined utilizing an antibody to Dkk1 (Dkk1-Ab) that blocked Dkk1 binding to both low density lipoprotein receptor-related protein 6 (LRP6)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b71791d8accfbc019712efc44c4440ee
https://doi.org/10.1002/jbmr.472
https://doi.org/10.1002/jbmr.472
Autor:
Sohye, Kang, Da, Ren, Gang, Xiao, Kristi, Daris, Lynette, Buck, Atim A, Enyenihi, Roman, Zubarev, Pavel V, Bondarenko, Rohini, Deshpande
Publikováno v:
Biotechnology and bioengineering. 111(4)
Mammalian cell culture performance is influenced by both intrinsic (genetic) and extrinsic (media and process) factors. In this study, intrinsic capacity of various monoclonal antibody-producing Chinese Hamster Ovary (CHO) cell lines was compared by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e323be961c40656db383acfd40824503
https://pubmed.ncbi.nlm.nih.gov/24249214
https://pubmed.ncbi.nlm.nih.gov/24249214