Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Krister Österlund"'
Autor:
Ruth Bylund, Jan-Arne Björkman, J.J.J. van Giezen, Thomas Antonsson, Fabrizio Giordanetto, Søren M. Andersen, Fredrik Zetterberg, Krister Österlund, Peter Bach, Helen Zachrisson
Publikováno v:
Journal of Medicinal Chemistry. 56:7015-7024
Synthesis and structure-activity relationships of ethyl 6-aminonicotinate acyl sulfonamides, which are potent antagonists of the P2Y12 receptor, are presented. Shifting from 5-chlorothienyl to benzyl sulfonamides significantly increased the potency i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6bf90454944693e2720d14dccde13db
https://doi.org/10.1021/jm400820m
https://doi.org/10.1021/jm400820m
Autor:
David Karis, Lance G. Hammerland, Andreas Wållberg, David Wensbo, Maria Boije, Alecia Peterson, Tor Svensson, Krister Österlund, Karolina Nilsson, Udo Bauer, Peter Bach
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:4792-4795
Synthesis and some structure-activity relationships for a new series of propargyl ethers as mGluR5 antagonists are reported.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f470dea9ecc0aa09cbf520e6cb1dc7e
https://doi.org/10.1016/j.bmcl.2006.06.079
https://doi.org/10.1016/j.bmcl.2006.06.079
Publikováno v:
The Journal of Organic Chemistry. 63:8067-8070
Asymmetric Total Synthesis of (+)-Tolterodine, a New Muscarinic Receptor Antagonist, via Copper-Assisted Asymmetric Conjugate Addition of Aryl Grignard Reagents to 3-Phenyl-prop-2-enoyl-oxazolidinones
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::106a700a85108573a6571495fcab639e
https://doi.org/10.1021/jo981259r
https://doi.org/10.1021/jo981259r
Autor:
Tor Svensson, Alecia Peterson, Krister Österlund, David Karis, Udo Bauer, Lance G. Hammerland, Karolina Nilsson, David Wensbo, Maria Boije, Peter Bach, Andreas Wållberg
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(18)
Studies of structure-activity relationships for the linker in a new series of metabotropic glutamate receptor 5 antagonists are presented together with in vitro and in vivo pharmacokinetic data.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73a169826f562c4c45c7621b7f2fd63d
https://pubmed.ncbi.nlm.nih.gov/16837196
https://pubmed.ncbi.nlm.nih.gov/16837196
Autor:
Alecia Peterson, David Wensbo, Andreas Wållberg, Jan P. Mattsson, Alexander Minidis, Krister Österlund, Martin Johansson, Jonas Malmström, Karolina Nilsson, Lance G. Hammerland
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(9)
Structure-activity relationship investigations of the thiopyrimidine (1), an HTS hit with micromolar activity as a metabotropic glutamate receptor 5 (mGluR5) antagonist, led to compounds with sub-micromolar activity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9263b5b19b58e095d917f85ea4492d9f
https://pubmed.ncbi.nlm.nih.gov/16481165
https://pubmed.ncbi.nlm.nih.gov/16481165
Autor:
Patrick Raboisson, Jan P. Mattsson, Krister Österlund, Andreas Wållberg, Karolina Nilsson, Udo Bauer, Susanne Elg, Lance G. Hammerland, Alecia Peterson
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(5)
Fenobam (1) was developed by McNeil Laboratories as an anxiolytic agent with an unknown molecular target in the late 1970s. In a recent publication, it was revealed that fenobam is a non-competitive mGluR5 antagonist. Herein, we present the structure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90fbd5882465ddf12590fc76dd35bacf
https://pubmed.ncbi.nlm.nih.gov/16380255
https://pubmed.ncbi.nlm.nih.gov/16380255
Autor:
Nidhal Selmi, Anders Broo, Emma J. Williams, William McCoull, Peter Barton, Nathaniel G. Martin, Gareth Coope, Krister Österlund, Jane E. Moore, David S. Clarke, Alastair J. H. Brown, Stephen Stokes, Eleanor Rosevere, Tor Svensson, Robert D. M. Davies, Alexander G. Dossetter, Graeme R. Robb, Elizabeth E. Kelly, Jane L. Holmes, Claire Newton, Victoria Ullah, David G.A. Morgan, Philip A. MacFaul, Laurent Knerr
Publikováno v:
MedChemComm. 4:456
A pyrazolo-pyrimidinone based series of growth hormone secretagogue receptor type 1a (GHS-R1a) antagonists and inverse agonists were identified using a scaffold hop from known quinazolinone GHS-R1a modulators. Lipophilicity was reduced to decrease hE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e338246543e6606730bbb19b24004e0
https://doi.org/10.1039/c2md20340e
https://doi.org/10.1039/c2md20340e