Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Kristen R. Hollinger"'
Autor:
Carolyn Tallon, Benjamin J. Bell, Medhinee M. Malvankar, Pragney Deme, Carlos Nogueras-Ortiz, Erden Eren, Ajit G. Thomas, Kristen R. Hollinger, Arindom Pal, Maja Mustapic, Meixiang Huang, Kaleem Coleman, Tawnjerae R. Joe, Rana Rais, Norman J. Haughey, Dimitrios Kapogiannis, Barbara S. Slusher
Publikováno v:
Translational Neurodegeneration, Vol 12, Iss 1, Pp 1-20 (2023)
Abstract Background Cognitive decline in Alzheimer’s disease (AD) is associated with hyperphosphorylated tau (pTau) propagation between neurons along synaptically connected networks, in part via extracellular vesicles (EVs). EV biogenesis is trigge
Externí odkaz:
https://doaj.org/article/d163368f208644598366636e9b045806
Autor:
Benjamin J. Bell, Kristen R. Hollinger, Pragney Deme, Shinji Sakamoto, Yuto Hasegawa, David Volsky, Atsushi Kamiya, Norman Haughey, Xiaolei Zhu, Barbara S. Slusher
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 23, Iss , Pp 100478- (2022)
Combined antiretroviral therapy ushered an era of survivable HIV infection in which people living with HIV (PLH) conduct normal life activities and enjoy measurably extended lifespans. However, despite viral control, PLH often experience a variety of
Externí odkaz:
https://doaj.org/article/0850c2e7117c4dc59e642809a5571c0e
Autor:
Xiaolei Zhu, Kristen R. Hollinger, Yiyao Huang, Alejandra Borjabad, Boe-Hyun Kim, Tanina Arab, Ajit G. Thomas, Mohammed Moniruzzaman, Lyndah Lovell, Andrey Turchinovich, Kenneth W. Witwer, David J. Volsky, Norman J. Haughey, Barbara S. Slusher
Publikováno v:
Neurobiology of Disease, Vol 169, Iss , Pp 105734- (2022)
People living with HIV (PLH) have significantly higher rates of cognitive impairment (CI) and major depressive disorder (MDD) versus the general population. The enzyme neutral sphingomyelinase 2 (nSMase2) is involved in the biogenesis of ceramide and
Externí odkaz:
https://doaj.org/article/dafd878bacf3408985cbb67f41a0b5db
Autor:
Carolyn Tallon, Benjamin J. Bell, Anjali Sharma, Arindom Pal, Medhinee M. Malvankar, Ajit G. Thomas, Seung-Wan Yoo, Kristen R. Hollinger, Kaleem Coleman, Elizabeth L. Wilkinson, Sujatha Kannan, Norman J. Haughey, Rangaramanujam M. Kannan, Rana Rais, Barbara S. Slusher
Publikováno v:
Pharmaceutics, Vol 14, Iss 10, p 2066 (2022)
Alzheimer’s disease (AD) is characterized by the progressive accumulation of amyloid-β and hyperphosphorylated tau (pTau), which can spread throughout the brain via extracellular vesicles (EVs). Membrane ceramide enrichment regulated by the enzyme
Externí odkaz:
https://doaj.org/article/5393689d5ecd4b8598d99f7d3e2fafda
Autor:
Kristen R. Hollinger, Anjali Sharma, Carolyn Tallon, Lyndah Lovell, Ajit G. Thomas, Xiaolei Zhu, Robyn Wiseman, Ying Wu, Siva P. Kambhampati, Kevin Liaw, Rishi Sharma, Camilo Rojas, Rana Rais, Sujatha Kannan, Rangaramanujam M. Kannan, Barbara S. Slusher
Publikováno v:
Nanotheranostics
Cognitive impairment is a common aspect of multiple sclerosis (MS) for which there are no treatments. Reduced brain N-acetylaspartylglutamate (NAAG) levels are linked to impaired cognition in various neurological diseases, including MS. NAAG levels a
Autor:
Kristen R. Hollinger, Jenny Lam, Camilo Rojas, Radim Nencka, Vijayabhaskar Veeravalli, Hubert Hřebabecký, Ajit G. Thomas, Michal Šála, Barbara S. Slusher, Rana Rais, Eliška Procházková, Ondřej Nešuta, Martin Kögler, Ranjeet Prasad Dash, Lyndah Lovell, Amanda Donoghue, Carolyn Tallon
Publikováno v:
J Med Chem
Neutral sphingomyelinase 2 (nSMase2) catalyzes the cleavage of sphingomyelin to phosphorylcholine and ceramide, an essential step in the formation and release of exosomes from cells that is critical for intracellular communication. Chronic increase o
Autor:
Carolyn Tallon, Benjamin J Bell, Medhinee Malvankar, Kristen R Hollinger, Ajit G Thomas, Seung Wan Yoo, Amrita Datta Chaudhuri, Ying Wu, Rana Rais, Norman J Haughey, Barbara S Slusher
Publikováno v:
Alzheimer's & Dementia. 17
Autor:
Arindom Pal, Carolyn Tallon, Rana Rais, Takashi Tsukamoto, Kenneth W. Witwer, Kristen R. Hollinger, Benjamin J. Bell, Barbara S. Slusher, Norman J. Haughey
Publikováno v:
Drug Discov Today
Extracellular vesicles (EVs) are indispensable mediators of intercellular communication, but they can also assume a nefarious role by ferrying pathological cargo that contributes to neurological, oncological, inflammatory, and infectious diseases. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf5886475f2acde556c22d29cef70615
https://europepmc.org/articles/PMC8364476/
https://europepmc.org/articles/PMC8364476/
Autor:
Anjali Sharma, Rishi Sharma, Kevin Liaw, Camilo Rojas, Rana Rais, Barbara S. Slusher, Xiaolei Zhu, Lyndah Lovell, Siva P. Kambhampati, Kristen R. Hollinger, Sujatha Kannan, Carolyn Tallon, Rangaramanujam M. Kannan, Ajit G. Thomas
Roughly half of all individuals with multiple sclerosis (MS) experience cognitive impairment, but there are no approved treatments that target this aspect of the disease. Recent studies link reduced brainN-acetylaspartylglutamate (NAAG) levels to imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5e19d911295c051cdc5778a91573b38
Autor:
Carolyn Tallon, Kevin Liaw, Kristen R. Hollinger, Ajit G. Thomas, Camilo Rojas, Sujatha Kannan, Ying Wu, Barbara S. Slusher, Xiaolei Zhu, Eva Prchalova, Atsushi Kamiya, Elizabeth S Khoury
Publikováno v:
J Alzheimers Dis
Background: Given the emergent aging population, the identification of effective treatments for Alzheimer’s disease (AD) is critical. Objective: We investigated the therapeutic efficacy of JHU-083, a brain-penetrable glutamine antagonist, in treati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b72af413042b9613254d54c30c3e9190
https://europepmc.org/articles/PMC7678030/
https://europepmc.org/articles/PMC7678030/