Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Kristen N. Ryan"'
Autor:
Dawn Sun, Kristen N. Ryan, Daniel Smith, Subramaniam Krishnananthan, Min Hu, Dauh-Rurng Wu, Wenge Cui, Paul C. Lobben, Arvind Mathur, Shuang Liu, Jennifer Naginskaya, Richard E. Olson, Peng Li, Jianqing Li, Alicia Ng
Publikováno v:
Tetrahedron: Asymmetry. 28:196-202
BMS-911278 was identified as a potent triple reuptake inhibitor potentially useful for the treatment of depression. The original racemic synthesis suffered from tedious and low recovery resolution and HPLC separation, as well as low-yielding hazardou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd99d111ddccc082e4c2c89c67ec4c3f
https://doi.org/10.1016/j.tetasy.2016.12.003
https://doi.org/10.1016/j.tetasy.2016.12.003
Publikováno v:
Journal of the American Chemical Society. 139(34)
The asymmetric hydrogenation of tetrasubstituted olefins provides direct access to very useful biological molecules and intermediates. The development of the technology has been slow, due in part to the synthetic challenges involved in developing chi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d6e73297d8852a22ca0cafcb849af97
https://pubmed.ncbi.nlm.nih.gov/28800391
https://pubmed.ncbi.nlm.nih.gov/28800391
Autor:
Cheng Guo, Liaqat Masih, David D. Manning, Peter R. Guzzo, Kristen N. Ryan, Jonathan D. Wierschke, Sok Hui Choo, William G. Earley, Nicholas M. Barnes, Zhenjun Zhang, Jennifer Naginskaya, Amy S Newman, Catherine A. Brady
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(11)
Serotonin type 3 (5-HT3) receptor partial agonists have been targeted as potential new drugs for the symptomatic relief of irritable bowel syndrome (IBS). Multiple diazepinone-based compounds have been discovered, which exhibit nanomolar binding affi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c335733d1983989f1f5c9d6a38536306
https://pubmed.ncbi.nlm.nih.gov/24755431
https://pubmed.ncbi.nlm.nih.gov/24755431
Autor:
Amy S. Butler, Catherine A. Brady, Svetlana Dobritsa, Marlene L. Cohen, Carla Hassler, Sok Hui Choo, Kristen N. Ryan, Nicholas M. Barnes, Alexander Usyatinsky, M. Inthikhab Sikkander, Christopher L. Cioffi, Kevin Fitzpatrick, Liaqat Masih, Zhenjun Zhang, David D. Manning, Jonathan D. Wierschke, Peter R. Guzzo, William G. Earley, Cheng Guo, Jennifer Naginskaya
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(1)
Serotonin type 3 (5-HT(3)) receptor partial agonists are being targeted as potential new drugs for the treatment of irritable bowel syndrome (IBS). Two new chemical series bearing indazole and indole cores have exhibited nanomolar binding affinity fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5bbdebdbe2f35d1a58c32fffc956826
https://pubmed.ncbi.nlm.nih.gov/21146988
https://pubmed.ncbi.nlm.nih.gov/21146988