Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Kristen N Bricker"'
1
Akademický článek
Orai3 and Orai1 mediate CRAC channel function and metabolic reprogramming in B cells
Autor: Scott M Emrich, Ryan E Yoast, Xuexin Zhang, Adam J Fike, Yin-Hu Wang, Kristen N Bricker, Anthony Y Tao, Ping Xin, Vonn Walter, Martin T Johnson, Trayambak Pathak, Adam C Straub, Stefan Feske, Ziaur SM Rahman, Mohamed Trebak
Publikováno v: eLife, Vol 12 (2023)
The essential role of store-operated Ca2+ entry (SOCE) through Ca2+ release-activated Ca2+ (CRAC) channels in T cells is well established. In contrast, the contribution of individual Orai isoforms to SOCE and their downstream signaling functions in B
Externí odkaz: https://doaj.org/article/5b4624a722da497c9f2661a9b380baec
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3
Context-Dependent miR-21 Regulation of TLR7-Mediated Autoimmune and Foreign Antigen–Driven Antibody-Forming Cell and Germinal Center Responses
Autor: Phillip P. Domeier, Kristen N. Bricker, Steven F. Ziegler, Nicholas M Choi, Adam J. Fike, Sara A. Luckenbill, Zia Ur Rahman, Stephanie L. Schell, Sathi Babu Chodisetti, Melinda J. Fasnacht
Publikováno v: J Immunol
MicroRNAs (miRNAs) are involved in healthy B cell responses and the loss of tolerance in systemic lupus erythematosus (SLE), although the role of many miRNAs remains poorly understood. Dampening miR-21 activity was previously shown to reduce splenome
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6b4a29c87d45fc56fcb71b39512bdf6
https://doi.org/10.4049/jimmunol.2001039
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4
STAT4 Is Largely Dispensable for Systemic Lupus Erythematosus–like Autoimmune- and Foreign Antigen–Driven Antibody-Forming Cell, Germinal Center, and Follicular Th Cell Responses
Autor: Zissis C. Chroneos, Sathi Babu Chodisetti, Mark H. Kaplan, Zia Ur Rahman, Kristen N. Bricker, Adam J. Fike, Nicholas M Choi
Publikováno v: ImmunoHorizons. 5:2-15
Genome-wide association studies identified variants in the transcription factor STAT4 gene and several other genes in the STAT4 signaling pathway, such as IL12A, IL12B, JAK2, and TYK2, which are associated with an increased risk of developing systemi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::657c316e00d979cc29f9d69a0f6b0565
https://doi.org/10.4049/immunohorizons.2000111
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5
Orai3 and Orai1 are essential for CRAC channel function and metabolic reprogramming in B cells
Autor: Scott M. Emrich, Ryan E. Yoast, Xuexin Zhang, Adam J. Fike, Yin-Hu Wang, Kristen N. Bricker, Anthony Tao, Ping Xin, Vonn Walter, Martin T. Johnson, Trayambak Pathak, Adam C. Straub, Stefan Feske, Ziaur S.M. Rahman, Mohamed Trebak
The essential role of store-operated Ca2+ entry (SOCE) through Ca2+ release-activated Ca2+ (CRAC) channels in T cells is well established. In contrast, the contribution of individual Orai isoforms to SOCE and their downstream signaling functions in B
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2e396a01d7ac2ecf4a599e7218f0ccbf
https://doi.org/10.1101/2022.05.06.490918
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7
Strain-Dependent Contribution of MAVS to Spontaneous Germinal Center Responses
Autor: Adam J. Fike, Sathi Babu Chodisetti, Nicholas M Choi, Stephanie L. Schell, Zia Ur Rahman, Kristen N. Bricker
Publikováno v: ImmunoHorizons. 3:463-477
Germinal centers (GCs) are essential for the production of somatically hypermutated, class-switched Abs that are protective against infection, but they also form in the absence of purposeful immunization or infection, and are termed spontaneous GCs (
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b74e775210e4aa11aa9f914aa19a03b
https://doi.org/10.4049/immunohorizons.1900048
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8
Akademický článek
STAT3 signaling in B cells controls germinal center zone organization and recycling
Autor: Adam J. Fike, Sathi Babu Chodisetti, Nathaniel E. Wright, Kristen N. Bricker, Phillip P. Domeier, Mark Maienschein-Cline, Aaron M. Rosenfeld, Sara A. Luckenbill, Julia L. Weber, Nicholas M. Choi, Eline T. Luning Prak, Malay Mandal, Marcus R. Clark, Ziaur S.M. Rahman
Publikováno v: Cell Reports, Vol 42, Iss 5, Pp 112512- (2023)
Summary: Germinal centers (GCs), sites of antibody affinity maturation, are organized into dark (DZ) and light (LZ) zones. Here, we show a B cell-intrinsic role for signal transducer and activator of transcription 3 (STAT3) in GC DZ and LZ organizati
Externí odkaz: https://doaj.org/article/90bb71ba5bd34d068395ef2779c48824
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