Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Kristen Michelle Mulvihill"'
Autor:
Andrew P. Crew, Meizhong Jin, Kristen Michelle Mulvihill, Mark J. Mulvihill, David Epstein, Qun-Sheng Ji, Shripad V. Bhagwat, Mridula Kadalbajoo, Andrew Cooke, Josef A. Rechka, Jonathan A. Pachter, Mark Bittner, Kam W. Siu, Yan Yao, Jing Wang, April Thelemann, Andrew Kleinberg
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:979-984
This Letter describes the medicinal chemistry effort towards a series of novel imidazo[1,5-a]pyrazine derived inhibitors of ACK1. Virtual screening led to the discovery of the initial hit, and subsequent exploration of structure-activity relationship
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb66157d50668f15d12c6b4c68463b3f
https://doi.org/10.1016/j.bmcl.2012.12.042
https://doi.org/10.1016/j.bmcl.2012.12.042
Autor:
Dan Sherman, Pawan Rastogi, An-Hu Li, Andrew Kleinberg, Ti Wang, Mark J. Mulvihill, Anthony Nigro, Heather Coate, Kristen Michelle Mulvihill, Andrew P. Crew, Mridula Kadalbajoo, Kam W. Siu, Ayako Honda, Radoslaw Laufer, David J. Beard, Arno G. Steinig, Doug Werner
Publikováno v:
Synthesis. 2010:1678-1686
A highly effective one-pot Friedlander quinoline synthesisfrom O-nitroarylcarbaldehydes and ketonesor aldehydes was developed and the scope and limitations of themethod were examined. The O-nitroarylcarbaldehydeswere reduced to O-aminoarylcarbaldehyd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08f67c0e37249d3f8abdc174bfb57b66
https://doi.org/10.1055/s-0029-1218701
https://doi.org/10.1055/s-0029-1218701
Autor:
Darla Landfair, Prafulla C. Gokhale, Qun-Sheng Ji, Robert A. Wild, Kristen Michelle Mulvihill, Meizhong Jin, Kenneth Foreman, Hanqing Dong, Gilda Mak, Andrew Kleinberg, Andy Cooke, Mark J. Mulvihill, Matthew O'Connor, Mark Bittner, Yan Yao, Kam W. Siu, Maryland Rosenfeld-Franklin, Jonathan A. Pachter
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(4)
Preclinical and emerging clinical evidence suggests that inhibiting insulin-like growth factor 1 receptor (IGF-1R) signaling may offer a promising therapeutic strategy for the treatment of several types of cancer. This Letter describes the medicinal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c89e64064f19f6bae3c17b1b2909d2d
https://pubmed.ncbi.nlm.nih.gov/21251824
https://pubmed.ncbi.nlm.nih.gov/21251824
Autor:
Kenneth Foreman, Mark J. Mulvihill, Caroline Pirrit, Kam W. Siu, Anthony Nigro, Gilda Mak, Ayako Honda, Neil W. Gibson, Andrew Cooke, Lixin Feng, Kristen Michelle Mulvihill, Arno G. Steinig, Hanqing Dong, Matthew O'Connor, Paula A. R. Tavares, Kathryn M. Stolz, Yingchuan Sun, Qun-Sheng Ji, Heather Coate, Maryland Rosenfeld-Franklin, Yan Yao
Publikováno v:
Bioorganicmedicinal chemistry. 16(3)
A series of novel, potent quinolinyl-derived imidazo[1,5-a]pyrazine IGF-IR (IGF-1R) inhibitors--most notably, cis-3-(3-azetidin-1-ylmethylcyclobutyl)-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-8-ylamine (AQIP)--is described. Synthetic details, st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e22a4df4a6696ed4e73207d83c986a9d
https://pubmed.ncbi.nlm.nih.gov/17983756
https://pubmed.ncbi.nlm.nih.gov/17983756
Autor:
Andrew P. Crew, Shripad V. Bhagwat, Mark J. Mulvihill, David Epstein, Andrew Cooke, Yan Yao, Mark Bittner, Qun-Sheng Ji, Meizhong Jin, Andrew Kleinberg, Jing Wang, April Thelemann, Josef A. Rechka, Jonathan A. Pachter, Kam W. Siu, Mridula Kadalbajoo, Kristen Michelle Mulvihill
Publikováno v:
Cancer Research. 73:2463-2463
Activated Cdc42-associated kinase (ACK1) is a non-receptor tyrosine kinase originally identified by virtue of its binding to GTP-bound small GTPase Cdc42. Considerable attention has been paid to ACK1’s involvement in cancer in recent years. For exa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0728effeee04557a92dd1ee775962d49
https://doi.org/10.1158/1538-7445.am2013-2463
https://doi.org/10.1158/1538-7445.am2013-2463