Zobrazeno 1 - 10 of 36 pro vyhledávání: '"Kristen McEachern"'
4
Safety, antitumor activity, and pharmacokinetics of dostarlimab, an anti-PD-1, in patients with advanced solid tumors: a dose–escalation phase 1 trial
Autor: Drew W. Rasco, Amita Patnaik, Kristen McEachern, Sharon Lu, Wei Guo, Lisa Blaydorn, Murali Beeram, Ellie Im, Amy Mirabella, Jasgit C. Sachdev, Hadi Danaee, Glen J. Weiss
Publikováno v: Cancer Chemotherapy and Pharmacology
Purpose New immuno-oncology therapies targeting programmed cell death receptor 1 (PD-1) have improved patient outcomes in a broad range of cancers. The objective of this analysis was to evaluate the PK, pharmacodynamics (PDy), and safety of dostarlim
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a01bdcc28b555d4d52481b0db48989cc
http://europepmc.org/articles/PMC8739161
Zobrazit plný text záznamu
6
Abstract 2508: Clinical significance of PARP7 (TIPARP) gene copy number alterations in human non-small cell and head & neck carcinomas
Autor: Viviana A. Ahumada, Kristen McEachern, Kristy Kuplast-Barr, Kurt Alex Schalper
Publikováno v: Cancer Research. 83:2508-2508
Introduction: PARP7, encoded by the TIPARP gene, is a monoART involved in cellular stress responses and with immunomodulatory functions in cancer. The PARP7 gene is amplified in a subset of squamous cell carcinomas and ongoing clinical studies are as
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b2d1eee213d79e797d0f4e90e17de050
https://doi.org/10.1158/1538-7445.am2023-2508
Zobrazit plný text záznamu
7
866 RBN-2397, a novel, potent, and selective PARP7 inhibitor, induces tumor-intrinsic type I interferon responses and adaptive immunity in preclinical models and patient tumors
Autor: Kristy Kuplast-Barr, Melissa Johnson, Manish Patel, Timothy Yap, Gerald Falchook, Patricia LoRusso, Ryan Abo, Chang Liu, Erika Manyak, Lisa Cleary, Viviana Bozon, Sudha Parasuraman, Heike Keilhack, Kristen McEachern
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundPARP7 is a mono-ART that is upregulated in response to cellular stress (e.g., viral infection, cigarette smoke), and suppresses the Type I interferon (IFN) response following cytosolic nucleic acid sensing. RBN-2397 is a first-in-class PARP
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cc7fe6a3608347c8b3043c4e29db724
https://doaj.org/article/c69f81a7d6be48219521485df3d41f01
Zobrazit plný text záznamu
9
Abstract 1836: RBN-2397, a novel, potent, and selective PARP7 inhibitor, induces tumor-intrinsic type I interferon responses and adaptive immunity in patient tumors
Autor: Kristy Kuplast-Barr, Melissa L. Johnson, Manish R. Patel, Timothy A. Yap, Gerald S. Falchook, Patricia LoRusso, Ryan Abo, Chang Liu, Erika L. Manyak, Lisa Cleary, Viviana Bozon, Sudha Parasuraman, Heike Keilhack, Kristen McEachern
Publikováno v: Cancer Research. 82:1836-1836
Background: PARP7 is a mono-ART that is upregulated in response to cellular stress (e.g., viral infection, cigarette smoke), and suppresses the Type I interferon (IFN) response following cytosolic nucleic acid sensing. RBN-2397 is a first-in-class PA
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a7e458d842d50569df36c0e5f2a68521
https://doi.org/10.1158/1538-7445.am2022-1836
Zobrazit plný text záznamu
10
Abstract 381: Elevated PARP7 expression in select cancers identifies a target population for RBN-2397 therapy
Autor: Radwa Sharaf, Kristen McEachern, Anupriya S. Kulkarni, Jodie Wong, David T. Ting, Katherine Xu, Heike Keilhack, Linda T. Nieman, Kristy Kuplast-Barr, Ryan Abo, Azfar Neyaz, Lee A. Albacker
Publikováno v: Cancer Research. 81:381-381
PARP7 (TIPARP) is a monoPARP which catalyzes the transfer of single units of ADP-ribose onto substrates to change their function. Its expression is upregulated during cellular stress, including viral infection or through the activation of the aryl hy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9b6dab620fc809dffd6f9b967be1da65
https://doi.org/10.1158/1538-7445.am2021-381
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje