Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Kristen Malebranche"'
Autor:
Satoshi Nakata, Junko Murai, Masayasu Okada, Haruhiko Takahashi, Tyler H Findlay, Kristen Malebranche, Akhila Parthasarathy, Satoshi Miyashita, Ramil Gabdulkhaev, Ilan Benkimoun, Sabine Druillennec, Sara Chabi, Eleanor Hawkins, Hiroaki Miyahara, Kensuke Tateishi, Shinji Yamashita, Shiori Yamada, Taiki Saito, Jotaro On, Jun Watanabe, Yoshihiro Tsukamoto, Junichi Yoshimura, Makoto Oishi, Toshimichi Nakano, Masaru Imamura, Chihaya Imai, Tetsuya Yamamoto, Hideo Takeshima, Atsuo T Sasaki, Fausto J Rodriguez, Sumihito Nobusawa, Pascale Varlet, Celio Pouponnot, Satoru Osuka, Yves Pommier, Akiyoshi Kakita, Yukihiko Fujii, Eric H Raabe, Charles G Eberhart, Manabu Natsumeda
Publikováno v:
Neuro-Oncology. 25:899-912
Background Intensive chemotherapeutic regimens with craniospinal irradiation have greatly improved survival in medulloblastoma patients. However, survival markedly differs among molecular subgroups and their biomarkers are unknown. Through unbiased s
Autor:
Satoshi, Nakata, Junko, Murai, Masayasu, Okada, Haruhiko, Takahashi, Tyler H, Findlay, Kristen, Malebranche, Akhila, Parthasarathy, Satoshi, Miyashita, Ramil, Gabdulkhaev, Ilan, Benkimoun, Sabine, Druillennec, Sara, Chabi, Eleanor, Hawkins, Hiroaki, Miyahara, Kensuke, Tateishi, Shinji, Yamashita, Shiori, Yamada, Taiki, Saito, Jotaro, On, Jun, Watanabe, Yoshihiro, Tsukamoto, Junichi, Yoshimura, Makoto, Oishi, Toshimichi, Nakano, Masaru, Imamura, Chihaya, Imai, Tetsuya, Yamamoto, Hideo, Takeshima, Atsuo T, Sasaki, Fausto J, Rodriguez, Sumihito, Nobusawa, Pascale, Varlet, Celio, Pouponnot, Satoru, Osuka, Yves, Pommier, Akiyoshi, Kakita, Yukihiko, Fujii, Eric H, Raabe, Charles G, Eberhart, Manabu, Natsumeda
Publikováno v:
Neuro-oncology.
Intensive chemotherapeutic regimens with craniospinal irradiation have greatly improved survival in medulloblastoma patients. However, survival markedly differs among molecular subgroups and their biomarkers are unknown. Through unbiased screening, w
Abstract 1141: The CoREST complex as a novel target to disrupt AT/RT’s abnormal epigenetic landscape
Autor:
Anupa Geethadevi, Marianne Collard, Nikhil Vaidya, Tyler Findlay, Kristen Malebranche, Charles Eberhart, Eric Raabe, Philip Cole, Rhoda Alani, Jeffrey Rubens
Publikováno v:
Cancer Research. 83:1141-1141
Atypical teratoid/rhabdoid tumors (AT/RT) are deadly infantile brain tumors. Their aggressive phenotype results from a single recurring biallelic loss-of-function mutation in genes encoding components of the SWI/SNF chromatin-remodeling complex - SMA
Autor:
Tyler Findlay, Kristen Malebranche, Anupa Geethadevi, Eric Raabe, Charles Eberhart, Jeffrey Rubens
Publikováno v:
Cancer Research. 83:5490-5490
We have previously identified high activation of both mTORC1 and mTORC2 in the aggressive infantile brain tumor, atypical teratoid/rhabdoid tumor (AT/RT). Paxalisib is a highly brain penetrant PI3k inhibitor which acts upstream of mTOR to simultaneou
Publikováno v:
Cancer Research. 82:5226-5226
Atypical teratoid/rhabdoid tumors (AT/RT) are aggressive pediatric brain tumors and the most common malignant brain tumors of infancy. The four-year event-free survival rate is only 37%. For patients with relapsed AT/RT, there are limited treatment o
Publikováno v:
Cancer Research. 82:5225-5225
Atypical teratoid/rhabdoid tumors (AT/RT) are the most common malignant brain tumors of infancy with a four-year event-free survival of 37%. Previously, we have identified high activation of both mTORC1 and mTORC2 through immunohistochemistry of 18 p
Publikováno v:
Neuro-Oncology. 24:i9-i9
We previously identified high activation of mTORC1 and mTORC2 in AT/RT by immunohistochemistry of 18 primary tumors expanding over each molecular subgroup of AT/RT. Paxalisib is a highly brain-penetrant PI3k inhibitor acting upstream of mTORC1/2 to f