Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Kristen M. Thelen"'
Autor:
Fabrizia Carbone, Andrea Ballabio, Aalekhya Biswas, Kristen M. Thelen, Sujeong Jin, Nunzia Pastore, Brunella Franco, Seth Richard, Sergio A. Gradilone, Estanislao Peixoto, Adrian P. Mansini, Stephanie Holtorf, Manuela Morleo
Publikováno v:
Am J Physiol Gastrointest Liver Physiol
Reduced ciliary expression is reported in several tumors, including cholangiocarcinoma (CCA). We previously showed primary cilia have tumor suppressor characteristics, and HDAC6 is involved in ciliary loss. However, mechanisms of ciliary disassembly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61d31682e25b7cf46f2822df3f07c0c8
https://doi.org/10.1152/ajpgi.00033.2020
https://doi.org/10.1152/ajpgi.00033.2020
Autor:
José Luis Lavín, Maite G. Fernandez-Barrena, Alvaro Santos-Laso, Jesper B. Andersen, Mauro D'Amato, Robert C. Huebert, Nidhi Jalan-Sakrikar, Kristen M. Thelen, Adelaida Lacasta, Gregory J. Gores, Aitor Esparza-Baquer, Oihane Erice, Elisa Lozano, Ana M. Aransay, Oscar Briz, Colm J O'Rourke, Luis Bujanda, Ander Matheu, Sergio A. Gradilone, Maite Merino-Azpitarte, Raul Jimenez-Agüero, Jose J.G. Marin, Marco Marzioni, Jesus M. Banales, Maria J. Perugorria
Publikováno v:
Journal of Hepatology. 67:72-83
Background & Aims Cholangiocarcinoma (CCA) is a biliary malignancy linked to genetic and epigenetic abnormalities, such as hypermethylation of SOX17 promoter. Here, the role of SOX17 in cholangiocyte differentiation and cholangiocarcinogenesis was st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30bacda2b6befa3822d1e3cf03c19dd6
https://doi.org/10.1016/j.jhep.2017.02.017
https://doi.org/10.1016/j.jhep.2017.02.017
Autor:
Christy E. Trussoni, Sergio A. Gradilone, Adrian P. Mansini, Sujeong Jin, Jesus M. Banales, Maetzin Cruz-Reyes, Gabriella B. Gajdos, Estanislao Peixoto, M.J. Perugorria, Maria J. Lorenzo Pisarello, Kristen M. Thelen, Nicholas F. LaRusso, Brynn N. Howard
Publikováno v:
Hepatology (Baltimore, Md.). 68(2)
Cholangiocytes normally express primary cilia, a multisensory organelle that detects signals from the cellular environment. Cilia are significantly reduced in cholangiocarcinoma (CCA) by a mechanism involving overexpression of histone deacetylase 6 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cedb80df89b9000a06c36bf8b70111b7
https://pubmed.ncbi.nlm.nih.gov/30506034
https://pubmed.ncbi.nlm.nih.gov/30506034
Autor:
Sergio A. Gradilone, Adrian P. Mansini, Sujeong Jin, Estanislao Peixoto, Cesar I. Gaspari, Kristen M. Thelen
Publikováno v:
Biochimica et biophysica acta. Molecular basis of disease. 1864(4 Pt)
Cholangiocytes, like most cells, express primary cilia extending from their membranes. These organelles function as antennae which detect stimuli from bile and transmit the information into cells regulating several signaling pathways involved in secr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e8b9797eeb7108ef2a16af61d217881
https://pubmed.ncbi.nlm.nih.gov/28625917
https://pubmed.ncbi.nlm.nih.gov/28625917
Autor:
Alvaro Santos-Laso, Kristen M. Thelen, M.J. Perugorria, Gregory J. Gores, José Luis Lavín, Nidhi Jalan-Sakrikar, Sergio A. Gradilone, Jose J.G. Marin, O. Erice, Maite G. Fernandez-Barrena, Adelaida Lacasta, Robert C. Huebert, Ana M. Aransay, Maite Merino-Azpitarte, Elisa Lozano, Luis Bujanda, Marco Marzioni, Raul Jimenez-Agüero, Jesus M. Banales
Publikováno v:
ResearcherID
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a73f30fb07afa1761a342d75e89b6df1
https://doi.org/10.1016/s0168-8278(16)01034-5
https://doi.org/10.1016/s0168-8278(16)01034-5
Publikováno v:
Cancer Research. 77:361-361
Cholangiocarcinoma (CCA) is a malignancy arising from cholangiocytes, the epithelial cells lining the biliary tree. CCA is an uncommon, but devastating cancer that is increasing in incidence. Over the past 3 decades, 5-years survival rates have remai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2db71df93d35896f3af7f9a23dd150d4
https://doi.org/10.1158/1538-7445.am2017-361
https://doi.org/10.1158/1538-7445.am2017-361