Extensive p-Tau Pathology and SDS-Stable p-Tau Oligomers in Alzheimer's Cortical Synapses

Autor: Harry V. Vinters, Kristen M. Henkins, Carol A. Miller, Sophie Sokolow, Lindsey B. Cornwell, Wayne W. Poon, Tommy Saing, Karen H. Gylys

Publikováno v: Brain Pathology. 22:826-833

Like amyloid beta (Aβ) oligomers, tau aggregates are increasingly recognized as potential key toxic intermediates in Alzheimer's disease (AD) and as therapeutic targets. P-tau co-localizes with Aβ in cortical AD synapses and may contribute to synap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::adde14d07bb700efa43c1a31244976f1
https://doi.org/10.1111/j.1750-3639.2012.00598.x

Pre-synaptic C-terminal truncated tau is released from cortical synapses in Alzheimer's disease

Autor: Wayne W. Poon, Karen H. Gylys, Bianca Gonzalez, Lindsey B. Cornwell, Carol A. Miller, Tina Bilousova, Kristen M. Henkins, Harry V. Vinters, Sophie Sokolow

Publikováno v: Sokolow, S; Henkins, KM; Bilousova, T; Gonzalez, B; Vinters, HV; Miller, CA; et al.(2015). Pre-synaptic C-terminal truncated tau is released from cortical synapses in Alzheimer's disease. Journal of Neurochemistry, 133(3), 368-379. doi: 10.1111/jnc.12991. UCLA: Retrieved from: http://www.escholarship.org/uc/item/6d37b68h
Journal of Neurochemistry, vol 133, iss 3
Sokolow, S; Henkins, KM; Bilousova, T; Gonzalez, B; Vinters, HV; Miller, CA; et al.(2015). Pre-synaptic C-terminal truncated tau is released from cortical synapses in Alzheimer's disease. Journal of Neurochemistry. doi: 10.1111/jnc.12991. UCLA: Retrieved from: http://www.escholarship.org/uc/item/4r75w527
Journal of neurochemistry, vol 133, iss 3

The microtubule-associated protein tau has primarily been associated with axonal location and function; however, recent work shows tau release from neurons and suggests an important role for tau in synaptic plasticity. In our study, we measured synap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71c57310765cfc4bca29f2a0963ddd32
http://www.escholarship.org/uc/item/6d37b68h

O4‐02‐01: Apoliprotein‐E is increased in Alzheimer's disease synapses and associates with amyloid beta

Autor: Kristen M. Henkins, Greg M. Cole, Carol A. Miller, Stephen Arold, Wayne W. Poon, Karen H. Gylys, Harry V. Vinters

Publikováno v: Alzheimer's & Dementia. 6

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dfd8061ee9285143b15a4cda6d2e25bf
https://doi.org/10.1016/j.jalz.2010.05.473

AD synapses contain abundant Aβ monomer and multiple soluble oligomers, including a 56-kDa assembly

Autor: Harry V. Vinters, Tina Bilousova, Sophie Sokolow, Wayne W. Poon, Gregory M. Cole, Karen H. Gylys, Kristen M. Henkins, Carol A. Miller

Publikováno v: Neurobiology of aging. 33(8)

Much evidence indicates that soluble amyloid beta (Aβ) oligomers are key mediators of early cognitive loss, but the localization and key peptide species remain unclear. We have used flow cytometry analysis to demonstrate that surviving Alzheimer's d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9f2d3f9fcdeb065eb897ad4bfa700fb
https://pubmed.ncbi.nlm.nih.gov/21741125

O2‐06‐03: A 56kD SDS‐stable peptide assembly is prominent among multiple oligomers in Alzheimer synapses

Autor: Carol A. Miller, Sophie Sokolow, Kristen M. Henkins, Karen H. Gylys, Harry V. Vinters, Gregory M. Cole, Chelsea Rhoades

Publikováno v: Alzheimer's & Dementia. 5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9c7f2d6c4c46eadaf64d6485de65d9d5
https://doi.org/10.1016/j.jalz.2009.05.363