Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Kristen M. Borchert"'
Autor:
Thomas P. Burris, Youyan Zhang, Kristen M. Borchert, Robert J. Schmidt, Keith A. Houck, Michele Dowless, Kelli S. Bramlett, Laura F. Michael, William K. Wilson, Li Wei Guo, James Ficorilli, Guosheng Liang, Guoqing Cao, Patrick I. Eacho, Thomas P. Beyer
Publikováno v:
Journal of Lipid Research, Vol 47, Iss 5, Pp 1037-1044 (2006)
Hypercholesterolemia is a major risk factor for coronary artery disease. Oxysterols are known to inhibit cholesterol biosynthesis and have been explored as potential antihypercholesterolemic agents. The ability of 3beta-hydroxy-5alpha-cholest-8(14)-e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2bc6e76d19908f42f57dd0ee462a333
http://www.sciencedirect.com/science/article/pii/S0022227520332521
http://www.sciencedirect.com/science/article/pii/S0022227520332521
Autor:
Wayne J. Glover, Christopher W. Gregory, Kristen M. Borchert, Gregory J. Smith, Sharon C. Presnell, James L. Mohler
Publikováno v:
Prostate Cancer and Prostatic Diseases. 2:257-263
Normal prostate epithelial cells are difficult to propagate in vitro without experimental immortalization. The goal of this study was to isolate and characterize a propagable epithelial cell line from normal adult rat prostate. Enrichment of prolifer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52a352328a7967cf0e9ad5315fe890bc
https://doi.org/10.1038/sj.pcan.4500363
https://doi.org/10.1038/sj.pcan.4500363
Autor:
Gary J. Smith, Joe W. Grisham, Sharon C. Presnell, Kristen M. Borchert, Michelle J. Hooth, William B. Coleman
Publikováno v:
The American Journal of Pathology. 153:1913-1921
Several studies have shown that cultured rat liver epithelial cells transform spontaneously after chronic maintenance in a confluent state in vitro. In the present study, multiple independent lineages of low-passage WB-F344 rat liver epithelial stem-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c39e7844d79b9829bb0bc8b0c3867fae
https://doi.org/10.1016/s0002-9440(10)65705-7
https://doi.org/10.1016/s0002-9440(10)65705-7
Autor:
Sharon C. Presnell, Christopher W. Gregory, James L. Mohler, Kristen M. Borchert, Gary J. Smith, Wayne J. Glover
Publikováno v:
Carcinogenesis. 19:585-590
The Dunning H rat prostate tumor (R3327H) is a widely used experimental model of human prostatic adenocarcinoma (CaP). The Dunning H tumor has been characterized as androgen-sensitive, androgen-receptor (AR) positive, prostate-specific antigen and pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5024aee23f0659f61eb9e4579faa2803
https://doi.org/10.1093/carcin/19.4.585
https://doi.org/10.1093/carcin/19.4.585
Autor:
Bernard E. Weissman, Kristen M. Borchert, Gary J. Smith, Karen D. McCullough, Gwyn L. Esch, Laura H. Reid, Joe W. Grisham, William B. Coleman
Publikováno v:
Molecular Carcinogenesis. 19:267-272
We previously demonstrated that a locus (or loci) linked to the D11S436 marker, which is within the approximately 6-Mb cen-p12 region of human chromosome 11, suppresses the tumorigenic potential of some rat liver epithelial tumor microcell hybrid (MC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92b704a1de0beb3d7652964d2db83dcc
https://doi.org/10.1002/(sici)1098-2744(199708)19:4<267::aid-mc8>3.0.co
https://doi.org/10.1002/(sici)1098-2744(199708)19:4<267::aid-mc8>3.0.co
Autor:
Kristen M, Borchert, Rachelle J, Sells Galvin, Laura V, Hale, O Joseph, Trask, Debra R, Nickischer, Keith A, Houck
Publikováno v:
Methods in enzymology. 414
Development of means to screen primary human cells rather than established cell lines is important in improving the predictive value of cellular assays in drug discovery. We describe a method of using automated fluorescent microscopy to detect activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c5b2c98b1645428ad53e718d60f59d83
https://pubmed.ncbi.nlm.nih.gov/17110191
https://pubmed.ncbi.nlm.nih.gov/17110191
Publikováno v:
Handbook of Assay Development in Drug Discovery ISBN: 9781574444711
Handbook of Assay Development in Drug Discovery
Handbook of Assay Development in Drug Discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5c4682e587e41bd33b4fdcfd6dfd934
https://doi.org/10.1201/9781420015706.ch26
https://doi.org/10.1201/9781420015706.ch26
Autor:
Laura V. Hale, Debra Nickischer, Keith A. Houck, O. Joseph Trask, Rachelle J. Sells Galvin, Kristen M. Borchert
Development of means to screen primary human cells rather than established cell lines is important in improving the predictive value of cellular assays in drug discovery. We describe a method of using automated fluorescent microscopy to detect activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87a0d2a502c034a7a2d9940d91de873b
https://doi.org/10.1016/s0076-6879(06)14009-4
https://doi.org/10.1016/s0076-6879(06)14009-4
Autor:
Keith A. Houck, Debra Nickischer, Robin J. Gonyier, Kristen M. Borchert, Laura V. Hale, O. Joseph Trask, Rachelle J. Sells Galvin, David L. Halladay, Charles A. Frolik
Publikováno v:
Assay and drug development technologies. 3(2)
We have developed a high-content screening (HCS) assay to find activators of Wnt/Frizzled (Wnt/Fzd), a pathway known to be important in bone formation. Utilizing primary human preosteoblasts as a model, activation of the Wnt/Fzd pathway was detected
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4372c5e560f775ff22663163ada46ac7
https://pubmed.ncbi.nlm.nih.gov/15871688
https://pubmed.ncbi.nlm.nih.gov/15871688
Publikováno v:
European journal of pharmacology. 512(1)
Forskolin and cAMP have been shown to have paradoxical effects in the regulation of expression levels of mRNA of cytochrome P450 3A (CYP3A) family members. We demonstrate in this study that forskolin upregulated the promoter for CYP3A4 independent of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10e4aa767c8eaa7d6d630fd70289bd72
https://pubmed.ncbi.nlm.nih.gov/15814084
https://pubmed.ncbi.nlm.nih.gov/15814084