Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Kristen L. Kroll"'
Autor:
Gareth Chapman, Julianna Determan, Haley Jetter, Komal Kaushik, Ramachandran Prakasam, Kristen L. Kroll
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109967- (2024)
Summary: Although human cortical interneurons (cINs) are a minority population in the cerebral cortex, disruption of interneuron development is a frequent contributor to neurodevelopmental disorders. Here, we utilized a model for deriving cINs from h
Externí odkaz:
https://doaj.org/article/ff561ed6030848bea8e74b05eb3bbc82
Autor:
Kesavan Meganathan, Ramachandran Prakasam, Dustin Baldridge, Paul Gontarz, Bo Zhang, Fumihiko Urano, Azad Bonni, Susan E. Maloney, Tychele N. Turner, James E. Huettner, John N. Constantino, Kristen L. Kroll
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-26 (2021)
Abstract Background Copy number variants (CNVs) linked to genes involved in nervous system development or function are often associated with neuropsychiatric disease. While CNVs involving deletions generally cause severe and highly penetrant patient
Externí odkaz:
https://doaj.org/article/28040e7bbee74beeb05f76bab9132942
Autor:
Emily M. A. Lewis, Kesavan Meganathan, Dustin Baldridge, Paul Gontarz, Bo Zhang, Azad Bonni, John N. Constantino, Kristen L. Kroll
Publikováno v:
Molecular Autism, Vol 10, Iss 1, Pp 1-23 (2019)
Abstract Background Autism spectrum disorder (ASD) is a neurodevelopmental disorder with pronounced heritability in the general population. This is largely attributable to the effects of polygenic susceptibility, with inherited liability exhibiting d
Externí odkaz:
https://doaj.org/article/b771a97a74a446ba8807749dd5918580
Autor:
Irene Antony, Elizabeth D. Buttermore, Gerarda Cappuccio, Juan Cruz Casabona, Gareth Chapman, Ivy Pin-Fang Chen, Harue Chou, Laurence Daheron, Alfred K. Dei-Ampeh, Thomas M. Durcan, Sandra J. Engle, Patrick Faloon, Kevin T. FitzGerald, Deborah L. French, James Giordano, Madison R. Glass, Komal Kaushik, Robin J. Kleiman, Teun Klein Gunnewiek, Kristen L. Kroll, Felix A. Kyere, Herbert M. Lachman, Brooke Latour, Mirjana Maletic-Savatic, Xiaobo Mao, Abigail Mariga, Gilles Maussion, Kesavan Meganathan, Swati Mishra, Nael Nadif Kasri, Andrew Petersen, Luisa Pimentel, Ramachandran Prakasam, Aiko Robert, Cecilia Rocha, Manuj Shah, Jason L. Stein, Maria Sundberg, Rik Van Der Kant, Coen Van Deursen, Elisa A. Waxman, Samantha Wu, Mingyao Ying, Damian W. Young, Jessica E. Young
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54858eaa91d9b0c887066db49c4fb4e5
https://doi.org/10.1016/b978-0-12-822277-5.01002-6
https://doi.org/10.1016/b978-0-12-822277-5.01002-6
Autor:
Irene Antony, Mishka Narasimhan, Renata Shen, Ramachandran Prakasam, Komal Kaushik, Gareth Chapman, Kristen L. Kroll
Publikováno v:
Stem cell reviews and reports.
Copy number variants (CNVs), involving duplication or deletion of susceptible intervals of the human genome, underlie a range of neurodevelopmental and neuropsychiatric disorders. As accessible in vivo animal models of these disorders often cannot be
Autor:
Joseph D. Dougherty, Natasha Marrus, Susan E. Maloney, Benjamin Yip, Sven Sandin, Tychele N. Turner, Din Selmanovic, Kristen L. Kroll, David H. Gutmann, John N. Constantino, Lauren A. Weiss
Publikováno v:
Neuron, vol 110, iss 20
Male sex is a strong risk factor for autism spectrum disorder (ASD). The leading theory for a "female protective effect" (FPE) envisions males and females have "differing thresholds" under a "liability threshold model" (DT-LTM). Specifically, this mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9584b7d63502551a4d8982e9fd2fb832
https://escholarship.org/uc/item/7048860t
https://escholarship.org/uc/item/7048860t
Autor:
James E. Huettner, Kristen L. Kroll, Kesavan Meganathan, Fumihiko Urano, Susan E. Maloney, Ramachandran Prakasam, Dustin Baldridge, Azad Bonni, John N. Constantino, Bo Zhang, Paul Gontarz, Tychele N. Turner
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-26 (2021)
BMC Biology
BMC Biology
Background Copy number variants (CNVs) linked to genes involved in nervous system development or function are often associated with neuropsychiatric disease. While CNVs involving deletions generally cause severe and highly penetrant patient phenotype
Autor:
Nickesha C. Anderson, Andrew J. Petersen, Pin-Fang Chen, Wardiya Afshar Saber, Kristen L. Kroll, Anita Bhattacharyya, Mustafa Sahin, Kesavan Meganathan
Publikováno v:
Stem Cell Reports
Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) and their differentiation into neural lineages is a revolutionary experimental system for studying neurological disorders, including intellectual and developmental disabilitie