Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Kristen L. Glass"'
Autor:
James C. Barrow, Kenneth E. Rittle, Lawrence C. Kuo, Audrey A. Wallace, Bobby J. Lucas, George F. Lundell, Beth Pietrak, Harold G. Selnick, Rebecca B. White, S. Dale Lewis, Franklin C. Clayton, Christina L. Newton, Youwei Yan, Janetta M. Pellicore, Daniel R. McMasters, Peter D. Williams, Philippe G. Nantermet, Kenneth J. Stauffer, Bradley K. Wong, Cynthia Miller-Stein, Kristen L. Glass, Julie A. Krueger, Mary Beth Young, Jacquelynn J. Cook, Joseph P. Vacca, Dennis L. Bohn
Publikováno v:
Journal of medicinal chemistry. 47(12)
In an effort to discover potent, clinically useful thrombin inhibitors, a rapid analogue synthetic approach was used to explore the P(1) region. Various benzylamines were coupled to a pyridine/pyrazinone P(2)-P(3) template. One compound with an o-thi
Autor:
Harold G. Selnick, Lawrence C. Kuo, Kellie J. Cutrona, Bobby J. Lucas, Kristen L. Glass, Joseph P. Vacca, Youwei Yan, S. Dale Lewis, Christina L. Newton, Daniel R. McMasters, Philippe G. Nantermet, Kenneth E. Rittle, William M. Sanders, Julie A. Krueger, Matthew M. Morrissette, James C. Barrow
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(20)
Thrombin inhibitors incorporating o -aminoalkylbenzylamides in the P1 position were designed, synthesized and found to have enhanced potency and selectivity in several different structural classes. X-ray crystallographic analysis of compound 24 bound
Autor:
Andrew M. Stern, Phung L. Ngo, James C. Barrow, Thomas M. Connolly, Janetta M. Pellicore, Michael J. Breslin, Mary Beth Young, Roger M. Freidinger, Harold G. Selnick, Jerzy Karczewski, Cindra L. Condra, John H. Hutchinson, Stanley L. Gaul, Philippe G. Nantermet, Robert J. Gould, Kristen L. Glass, Rodney A. Bednar
Publikováno v:
Bioorganicmedicinal chemistry letters. 11(20)
Thrombin is the most potent agonist of platelet activation, and its effects are predominantly mediated by platelet thrombin receptors. Therefore, antagonists of the thrombin receptor have potential utility for the treatment of thrombotic disorders. S
Autor:
C. J. Woyden, Stacey O'Malley, James C. Barrow, Roger M. Freidinger, Raymond S.L. Chang, Kristen L. Glass, Harold G. Selnick
Publikováno v:
ChemInform. 31
Several 1,3-diaminocyclopentane linked α 1a -receptor antagonists were prepared using a divergent chemical strategy that allows for rapid analysis of all stereochemical permutations for their effect on α 1 -receptor binding.
Autor:
Kelem Kassahun, Philippe G. Nantermet, Roger M. Freidinger, Timothy V. Olah, Carlos Forray, Harold G. Selnick, Thomas G. Steele, Theodore P. Broten, James C. Barrow, Kenneth E. Rittle, Raymond S.L. Chang, Duane R. Reiss, Carl F. Homnick, Rick W. Ransom, Paul J. Kling, Kristen L. Glass, A. Barrish, Kevin F. Gilbert, Paula Leppert, Stacey O'Malley, Dhanapalan Nagarathnam, Terry W. Schorn, Joan D. Ellis
Publikováno v:
Journal of medicinal chemistry. 43(14)
alpha(1) Adrenergic receptors mediate both vascular and lower urinary tract tone, and alpha(1) receptor antagonists such as terazosin (1b) are used to treat both hypertension and benign prostatic hyperplasia (BPH). Recently, three different subtypes