Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Kristen Kay"'
Autor:
Christopher Hubert, Kelly Mitchell, Samuel Sprowls, Sajina Shakya, Sonali Arora, Daniel J. Silver, Christopher M. Goins, Lisa Wallace, Gustavo Roversi, Rachel Schafer, Kristen Kay, Tyler E. Miller, Adam Lauko, John Bassett, Anjali Kashyap, J. D’Amato Kass, Erin E. Mulkearns-Hubert, Sadie Johnson, Joseph Alvarado, Jeremy N. Rich, Patrick J. Paddison, Anoop P. Patel, Shaun R. Stauffer, Christopher G. Hubert, Justin D. Lathia
Publikováno v:
Journal of Clinical and Translational Science, Vol 7, Pp 107-107 (2023)
OBJECTIVES/GOALS: Glioblastomas (GBMs) are heterogeneous, treatment-resistant tumors that are driven by populations of cancer stem cells (CSCs). In this study, we perform an epigenetic-focused functional genomics screen in GBM organoids and identify
Externí odkaz:
https://doaj.org/article/38b0f34846504b9fac37c7e24f076612
Autor:
Dionysios C. Watson, Defne Bayik, Simon Storevik, Shannon Sherwin Moreino, Samuel A. Sprowls, Jianhua Han, Mina Thue Augustsson, Adam Lauko, Palavalasa Sravya, Gro Vatne Røsland, Katie Troike, Karl Johan Tronstad, Sabrina Wang, Katharina Sarnow, Kristen Kay, Taral R. Lunavat, Daniel J. Silver, Sahil Dayal, Justin Vareecal Joseph, Erin Mulkearns-Hubert, Lars Andreas Rømo Ystaas, Gauravi Deshpande, Joris Guyon, Yadi Zhou, Capucine R. Magaut, Juliana Seder, Laura Neises, Sarah E. Williford, Johannes Meiser, Andrew J. Scott, Peter Sajjakulnukit, Jason A. Mears, Rolf Bjerkvig, Abhishek Chakraborty, Thomas Daubon, Feixiong Cheng, Costas A. Lyssiotis, Daniel R. Wahl, Anita B. Hjelmeland, Jubayer A. Hossain, Hrvoje Miletic, Justin D. Lathia
Publikováno v:
Nature Cancer. 4:648-664
The transfer of intact mitochondria between heterogeneous cell types has been confirmed in various settings, including cancer. However, the functional implications of mitochondria transfer on tumor biology are poorly understood. Here we show that mit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e2cd76169f757aefbec27866da906b8
https://doi.org/10.1038/s43018-023-00556-5
https://doi.org/10.1038/s43018-023-00556-5
Autor:
Kelly Mitchell, Samuel A. Sprowls, Sonali Arora, Sajina Shakya, Daniel J. Silver, Christopher M. Goins, Lisa Wallace, Gustavo Roversi, Rachel E. Schafer, Kristen Kay, Tyler E. Miller, Adam Lauko, John Bassett, Anjali Kashyap, Jonathan D'Amato Kass, Erin E. Mulkearns-Hubert, Sadie Johnson, Joseph Alvarado, Jeremy N. Rich, Eric C. Holland, Patrick J. Paddison, Anoop P. Patel, Shaun R. Stauffer, Christopher G. Hubert, Justin D. Lathia
Publikováno v:
Genes & Development. 37:86-102
Glioblastomas (GBMs) are heterogeneous, treatment-resistant tumors driven by populations of cancer stem cells (CSCs). However, few molecular mechanisms critical for CSC population maintenance have been exploited for therapeutic development. We develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ceec354fa1d7b6ded682eadfc70abc81
https://doi.org/10.1101/gad.349803.122
https://doi.org/10.1101/gad.349803.122
Autor:
Defne Bayik, Cynthia F. Bartels, Katreya Lovrenert, Dionysios C. Watson, Duo Zhang, Kristen Kay, Juyeun Lee, Adam Lauko, Sadie Johnson, Alice Lo, Daniel J. Silver, Mary McGraw, Matthew Grabowski, Alireza M. Mohammadi, Filippo Veglia, Yi Fan, Michael A. Vogelbaum, Peter Scacheri, Justin D. Lathia
Publikováno v:
Cancer Res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cc559b31c98ec812a2f49d917a05936
https://europepmc.org/articles/PMC10183804/
https://europepmc.org/articles/PMC10183804/
Autor:
Justin D. Lathia, Peter Scacheri, Michael A. Vogelbaum, Yi Fan, Filippo Veglia, Alireza M. Mohammadi, Matthew Grabowski, Mary McGraw, Daniel J. Silver, Alice Lo, Sadie Johnson, Adam Lauko, Juyeun Lee, Kristen Kay, Duo Zhang, Dionysios C. Watson, Katreya Lovrenert, Cynthia F. Bartels, Defne Bayik
In multiple types of cancer, an increased frequency in myeloid-derived suppressor cells (MDSC) is associated with worse outcomes and poor therapeutic response. In the glioblastoma (GBM) microenvironment, monocytic (m) MDSCs represent the predominant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f035746d988c956f724b41ac61c3c464
https://doi.org/10.1158/0008-5472.c.6514265.v2
https://doi.org/10.1158/0008-5472.c.6514265.v2
Autor:
Justin D. Lathia, Peter Scacheri, Michael A. Vogelbaum, Yi Fan, Filippo Veglia, Alireza M. Mohammadi, Matthew Grabowski, Mary McGraw, Daniel J. Silver, Alice Lo, Sadie Johnson, Adam Lauko, Juyeun Lee, Kristen Kay, Duo Zhang, Dionysios C. Watson, Katreya Lovrenert, Cynthia F. Bartels, Defne Bayik
Supplementary Data from Distinct Cell Adhesion Signature Defines Glioblastoma Myeloid-Derived Suppressor Cell Subsets
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36941736fe1a9846466179d5f4256468
https://doi.org/10.1158/0008-5472.22718380
https://doi.org/10.1158/0008-5472.22718380
Autor:
Defne Bayik, Cynthia F. Bartels, Katreya Lovrenert, Dionysios C. Watson, Duo Zhang, Kristen Kay, Juyeun Lee, Adam Lauko, Sadie Johnson, Alice Lo, Daniel J. Silver, Mary McGraw, Matthew Grabowski, Alireza M. Mohammadi, Filippo Veglia, Yi Fan, Michael A. Vogelbaum, Peter Scacheri, Justin D. Lathia
Publikováno v:
Cancer Res
In multiple types of cancer, an increased frequency in myeloid-derived suppressor cells (MDSC) is associated with worse outcomes and poor therapeutic response. In the glioblastoma (GBM) microenvironment, monocytic (m) MDSCs represent the predominant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4c4cff4eb8c0992a5c20bc40aa9d770
https://europepmc.org/articles/PMC9664137/
https://europepmc.org/articles/PMC9664137/
Publikováno v:
NeuroMolecular Medicine. 24:50-55
Glioblastoma (GBM), the most common primary malignant brain tumor, remains difficult to treat and shares phenotypes, including an aberrant immune response, with other neurological disorders. Understanding the cellular and molecular mechanisms underly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d163e1a93eafa92633fd765d7091577f
https://doi.org/10.1007/s12017-021-08659-x
https://doi.org/10.1007/s12017-021-08659-x
Autor:
Dionysios Watson, Defne Bayik, Adam Lauko, Samuel Sprowls, Gauravi Deshpande, Sarah Wilifford, Katie Troike, Daniel Silver, Sabrina Wang, Juliana Seder, Kristen Kay, Anita Hjelmeland, Justin Lathia
Publikováno v:
Neuro-Oncology. 24:vii286-vii287
Mitochondrial transfer occurs both in stroke (central nervous system) and inflammatory pain (peripheral nerves). However, its role in glioblastoma (GBM) remains poorly understood. We hypothesized that mitochondrial transfer from non-malignant to GBM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c48fd900218213d93f231afbb563a76
https://doi.org/10.1093/neuonc/noac209.1112
https://doi.org/10.1093/neuonc/noac209.1112
Autor:
Defne Bayik, Cynthia Bartels, Katreya Lovrenert, Duo Zhang, Dionysios Watson, Kristen Kay, Juyeun Lee, Michael Vogelbaum, Yi Fan, Peter Scacheri, Justin Lathia
Publikováno v:
Neuro-Oncology. 24:vii134-vii135
Accumulation of various immunosuppressive myeloid cells, including myeloid-derived suppressor cells (MDSCs), facilitates progression and treatment resistance of glioblastoma (GBM). We previous demonstrated that monocytic MDSCs (mMDSCs) but not granul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05c16c6f8360b5314050ff10043be398
https://doi.org/10.1093/neuonc/noac209.515
https://doi.org/10.1093/neuonc/noac209.515