Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Kristen John"'
Autor:
Erik B. Faber, Luxin Sun, Jian Tang, Emily Roberts, Sornakala Ganeshkumar, Nan Wang, Damien Rasmussen, Abir Majumdar, Laura E. Hirsch, Kristen John, An Yang, Hira Khalid, Jon E. Hawkinson, Nicholas M. Levinson, Vargheese Chennathukuzhi, Daniel A. Harki, Ernst Schönbrunn, Gunda I. Georg
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Compared to most ATP-site kinase inhibitors, small molecules that target an allosteric pocket have the potential for improved selectivity due to the often observed lower structural similarity at these distal sites. Despite their promise, rel
Externí odkaz:
https://doaj.org/article/43490103b21742f1887f75facd34c438
Autor:
Carolyn N. Paulson, Kristen John, Ryan M. Baxley, Fredy Kurniawan, Kayo Orellana, Rawle Francis, Alexandra Sobeck, Brandt F. Eichman, Walter J. Chazin, Hideki Aihara, Gunda I. Georg, Jon E. Hawkinson, Anja-Katrin Bielinsky
Publikováno v:
Open Biology, Vol 9, Iss 8 (2019)
Minichromosome maintenance protein 10 (Mcm10) is essential for DNA unwinding by the replisome during S phase. It is emerging as a promising anti-cancer target as MCM10 expression correlates with tumour progression and poor clinical outcomes. Here we
Externí odkaz:
https://doaj.org/article/5150118e038e43728fa377af3bba1099
Autor:
Irina Bancos, John Paul Bida, Defeng Tian, Mary Bundrick, Kristen John, Molly Nelson Holte, Yeng F Her, Debra Evans, Dyana T Saenz, Eric M Poeschla, Derek Hook, Gunda Georg, L James Maher
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56827 (2013)
Classical tumor suppressor genes block neoplasia by regulating cell growth and death. A remarkable puzzle is therefore presented by familial paraganglioma (PGL), a neuroendocrine cancer where the tumor suppressor genes encode subunits of succinate de
Externí odkaz:
https://doaj.org/article/f59d566d9d2d4a60a0109f1d98d39a5c
Autor:
Jayme L Dahlin, Rondedrick Sinville, Jonathan Solberg, Hui Zhou, Junhong Han, Subhashree Francis, Jessica M Strasser, Kristen John, Derek J Hook, Michael A Walters, Zhiguo Zhang
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e78877 (2013)
The lysine acetyltransferase (KAT) Rtt109 forms a complex with Vps75 and catalyzes the acetylation of histone H3 lysine 56 (H3K56ac) in the Asf1-H3-H4 complex. Rtt109 and H3K56ac are vital for replication-coupled nucleosome assembly and genotoxic res
Externí odkaz:
https://doaj.org/article/23a70466ae2746d7bcc2f8a8d3584186
Autor:
Kristen John
Publikováno v:
American Journal of Physical Medicine & Rehabilitation. 102:A1-A234
Autor:
Erik B. Faber, Nan Wang, Kristen John, Luxin Sun, Henry L. Wong, David Burban, Rawle Francis, Defeng Tian, Kwon H. Hong, An Yang, Liming Wang, Mazen Elsaid, Hira Khalid, Nicholas M. Levinson, Ernst Schönbrunn, Jon E. Hawkinson, Gunda I. Georg
Publikováno v:
Journal of Medicinal Chemistry. 66:1928-1940
Autor:
Erik B. Faber, Nan Wang, Kristen John, Luxin Sun, David Burban, Henry L. Wong, Rawle Francis, Defeng Tian, Kwon H. Hong, An Yang, Liming Wang, Mazen Elsaid, Hira Khalid, Nicholas Levinson, Ernst Schönbrunn, Jon E. Hawkinson, Gunda Georg
Despite the status of cyclin-dependent kinase 2 (CDK2) as a validated target for both anticancer and contraceptive indications, a CDK2 inhibitor with exquisite selectivity has been historically challenging, largely due to the structural similarity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a40cb086dde45184ebee3b82d2da24e6
https://doi.org/10.26434/chemrxiv-2022-4h8lf-v2
https://doi.org/10.26434/chemrxiv-2022-4h8lf-v2
Autor:
Erik B. Faber, Jian Tang, Emily Roberts, Sornakala Ganeshkumar, Luxin Sun, Nan Wang, Damien Rasmussen, Abir Majumdar, Kristen John, An Yang, Hira Khalid, Jon E. Hawkinson, Nicholas M. Levinson, Ernst Schönbrunn, Vargheese Chennathukuzhi, Daniel A. Harki, Gunda I. Georg
Compared to most ATP-site kinase inhibitors, small molecules that target an allosteric pocket have the potential for improved selectivity due to the often observed lower structural similarity at these distal sites. Despite their promise, relatively f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a75b00356ddac831362a32d9e2bc925
https://doi.org/10.1101/2022.06.30.497818
https://doi.org/10.1101/2022.06.30.497818
Autor:
Naiara Santana-Codina, Huan Zhang, Maria Quiles del Rey, Kevin S. Kapner, Ajami Gikandi, Callum Malcolm, Clara Poupault, Miljan Kuljanin, Kristen John, Douglas E. Biancur, Brandon Chen, Nupur Das, Kristen Lowder, Connor J. Hennessey, Wesley Huang, Annan Yang, Yatrik M. Shah, Jonathan A. Nowak, Andrew J. Aguirre, Joseph D. Mancias
Publikováno v:
Cancer Research. 82:A075-A075
Pancreatic ductal adenocarcinomas (PDAC) depend on autophagy for survival; however, the metabolic substrates that autophagy provides to drive PDAC progression are unclear. Ferritin, the cellular iron storage complex, is targeted for lysosomal degrada
Autor:
Svenja M. Sake, Xiaoyu Zhang, Manoj Kumar Rajak, Melanie Urbanek-Quaing, Arnaud Carpentier, Antonia P. Gunesch, Christina Grethe, Alina Matthaei, Jessica Rückert, Marie Galloux, Thibaut Larcher, Ronan Le Goffic, Fortune Hontonnou, Arnab K. Chatterjee, Kristen Johnson, Kaycie Morwood, Katharina Rox, Walid A. M. Elgaher, Jiabin Huang, Martin Wetzke, Gesine Hansen, Nicole Fischer, Jean-Francois Eléouët, Marie-Anne Rameix-Welti, Anna K. H. Hirsch, Elisabeth Herold, Martin Empting, Chris Lauber, Thomas F. Schulz, Thomas Krey, Sibylle Haid, Thomas Pietschmann
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Respiratory syncytial virus (RSV) is a common cause of acute lower respiratory tract infection in infants, older adults and the immunocompromised. Effective directly acting antivirals are not yet available for clinical use. To address this,
Externí odkaz:
https://doaj.org/article/66d08a2bbc3740f4a9e811166d229bd4