Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Kristen J, Radford"'
Autor:
Ellen R. Gillespie, Laura F. Grice, Isabel G. Courtney, Hong Wa Lao, Woncheol Jung, Sonny Ramkomuth, Jacky Xie, David A. Brown, James Walsham, Kristen J. Radford, Quan H. Nguyen, Marc J. Ruitenberg
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-20 (2024)
Abstract Next-generation humanised mouse models and single-cell RNA sequencing (scRNAseq) approaches enable in-depth studies into human immune cell biology. Here we used NSG-SGM3 mice engrafted with human umbilical cord haematopoietic stem cells to i
Externí odkaz:
https://doaj.org/article/40a7cde76523424a9dc3bc7e32ce0e7a
Autor:
Sherman S. Leung, Nataliya Lenchik, Clayton Mathews, Alberto Pugliese, Domenica A. McCarthy, Selena Le Bagge, Adam Ewing, Mark Harris, Kristen J. Radford, Danielle J. Borg, Ivan Gerling, Josephine M. Forbes
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Hypoglycemia in type 1 diabetes associates with changes in the pancreatic islet α cells, where the receptor for advanced glycation end products (RAGE) is highly expressed. This study compared islet RAGE expression in donors without diabetes
Externí odkaz:
https://doaj.org/article/1e61b2e4072243548923a79cf1259cab
Autor:
Ee Shan Pang, Ghazal Daraj, Katherine R. Balka, Dominic De Nardo, Christophe Macri, Hubertus Hochrein, Kelly-Anne Masterman, Peck S. Tan, Angus Shoppee, Zoe Magill, Nazneen Jahan, Mariam Bafit, Yifan Zhan, Benjamin T. Kile, Kate E. Lawlor, Kristen J. Radford, Mark D. Wright, Meredith O’Keeffe
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Stimulator of Interferon Genes (STING) is a cytosolic sensor of cyclic dinucleotides (CDNs). The activation of dendritic cells (DC) via the STING pathway, and their subsequent production of type I interferon (IFN) is considered central to eradicating
Externí odkaz:
https://doaj.org/article/70cc408876864abf9485d6da1eda5714
Autor:
Karen Gu, Carina Walpole, Shayarana Gooneratne, Xin Liu, Oscar L Haigh, Kristen J Radford, Mark MW Chong
Publikováno v:
Clinical & Translational Immunology, Vol 11, Iss 1, Pp n/a-n/a (2022)
Abstract Objectives DROSHA and DICER have central roles in the biogenesis of microRNAs (miRNAs). However, we previously showed that in the murine system, DROSHA has an alternate function where it directly recognises and cleaves protein‐coding messe
Externí odkaz:
https://doaj.org/article/d26fad94f2b644b199876fd86b5b27f5
Autor:
Victoria Atkinson, Kelly-Anne Masterman, Ingrid M Leal-Rojas, Frances E Pearson, Kristen J Radford, Yoke Seng Lee, Liam J O'Brien, Carina M Walpole, Andrew Barbour
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 3 (2021)
Background The conventional type 1 dendritic cell subset (cDC1) is indispensable for tumor immune responses and the efficacy of immune checkpoint inhibitor (ICI) therapies in animal models but little is known about the role of the human CD141+ DC cDC
Externí odkaz:
https://doaj.org/article/641ac534cc72482c8769def2a4229137
Autor:
Kirsteen M Tullett, Peck Szee Tan, Hae-Young Park, Ralf B Schittenhelm, Nicole Michael, Rong Li, Antonia N Policheni, Emily Gruber, Cheng Huang, Alex J Fulcher, Jillian C Danne, Peter E Czabotar, Linda M Wakim, Justine D Mintern, Georg Ramm, Kristen J Radford, Irina Caminschi, Meredith O'Keeffe, Jose A Villadangos, Mark D Wright, Marnie E Blewitt, William R Heath, Ken Shortman, Anthony W Purcell, Nicos A Nicola, Jian-Guo Zhang, Mireille H Lahoud
Publikováno v:
eLife, Vol 9 (2020)
The dendritic cell receptor Clec9A facilitates processing of dead cell-derived antigens for cross-presentation and the induction of effective CD8+ T cell immune responses. Here, we show that this process is regulated by E3 ubiquitin ligase RNF41 and
Externí odkaz:
https://doaj.org/article/ce7301ac4e2c47ffba46b495f1882e5b
Autor:
Kelly-Anne Masterman, Oscar L Haigh, Kirsteen M Tullett, Ingrid M Leal-Rojas, Carina Walpole, Frances E Pearson, Jonathon Cebon, Christopher Schmidt, Liam O'Brien, Nikita Rosendahl, Ghazal Daraj, Irina Caminschi, Eric H Gschweng, Roger P Hollis, Donald B Kohn, Mireille H Lahoud, Kristen J Radford
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background Dendritic cells (DCs) are crucial for the efficacy of cancer vaccines, but current vaccines do not harness the key cDC1 subtype required for effective CD8+ T-cell-mediated tumor immune responses. Vaccine immunogenicity could be enhanced by
Externí odkaz:
https://doaj.org/article/11cf9f6bcce340f58753253d7529688c
Autor:
Frances E Pearson, Kirsteen M Tullett, Ingrid M Leal‐Rojas, Oscar L Haigh, Kelly‐Anne Masterman, Carina Walpole, John S Bridgeman, James E McLaren, Kristin Ladell, Kelly Miners, Sian Llewellyn‐Lacey, David A Price, Antje Tunger, Marc Schmitz, John J Miles, Mireille H Lahoud, Kristen J Radford
Publikováno v:
Clinical & Translational Immunology, Vol 9, Iss 6, Pp n/a-n/a (2020)
Abstract Objectives Vaccines that prime Wilms' tumor 1 (WT1)‐specific CD8+ T cells are attractive cancer immunotherapies. However, immunogenicity and clinical response rates may be enhanced by delivering WT1 to CD141+ dendritic cells (DCs). The C
Externí odkaz:
https://doaj.org/article/d7716a6649ca41f9a6290ec9da9eae79
Autor:
Md. Al Amin Sikder, Ridwan B. Rashid, Tufael Ahmed, Ismail Sebina, Daniel Howard, Md. Ashik Ullah, Muhammed Mahfuzur Rahman, Jason P. Lynch, Bodie Curren, Rhiannon B. Werder, Jennifer Simpson, Alec Bissell, Mark Morrison, Carina Walpole, Kristen J. Radford, Vinod Kumar, Trent M. Woodruff, Tan HuiYing, Ayesha Ali, Gerard E. Kaiko, John W. Upham, Robert D. Hoelzle, Páraic Ó Cuív, Patrick G. Holt, Paul G. Dennis, Simon Phipps
SummarySevere lower respiratory infection (sLRI) are a major cause of infant morbidity and mortality, and predispose to later chronic respiratory diseases such as asthma. Poor maternal diet during pregnancy is a risk factor for sLRI in the offspring.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84b5a6cbb565490e4bbe2abb21101ca5
https://doi.org/10.1101/2023.01.05.522516
https://doi.org/10.1101/2023.01.05.522516
Autor:
Elise Gressier, Jonas Schulte-Schrepping, Lev Petrov, Sophia Brumhard, Paula Stubbemann, Anna Hiller, Benedikt Obermayer, Jasper Spitzer, Tomislav Kostevc, Paul G. Whitney, Annabell Bachem, Alexandru Odainic, Carolien van de Sandt, Thi H. O. Nguyen, Thomas Ashhurst, Kayla Wilson, Clare V. L. Oates, Linden. J. Gearing, Tina Meischel, Katharina Hochheiser, Marie Greyer, Michele Clarke, Maike Kreutzenbeck, Sarah S. Gabriel, Wolfgang Kastenmüller, Christian Kurts, Sarah L. Londrigan, Axel Kallies, Katherine Kedzierska, Paul J. Hertzog, Eicke Latz, Yu-Chen E. Chen, Kristen J. Radford, Michael Chopin, Jan Schroeder, Florian Kurth, Thomas Gebhardt, Leif E. Sander, Birgit Sawitzki, Joachim L. Schultze, Susanne V. Schmidt, Sammy Bedoui
Publikováno v:
Nature immunology 24(6), 979-990 (2023). doi:10.1038/s41590-023-01517-x
Antiviral CD8+ T cell immunity depends on the integration of various contextual cues, but how antigen-presenting cells (APCs) consolidate these signals for decoding by T cells remains unclear. Here, we describe gradual interferon-α/interferon-β (IF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1fa2efef3db05d38b32977cd1c0284b