Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Kristen J, Nikula"'
Autor:
Graham Paul, Stuart W. Naylor, Nicholas P. Macri, Scott Manetz, Richard Haworth, A. Peter Hall, David Jones, Thierry Flandre, Jeffrey S. Tepper, Michela Gregori, Annick Cauvin, Molly H. Boyle, Sydney Mukaratirwa, Alison Wolfreys, Renaud Fleurance, Inge Tarnow, Kristen J. Nikula, Alessandro Piaia, Mark Price, Ian Robinson, Andrew Allen, Tom Gelzleichter, Mark C Freke, Karyn Colman, Andreas M Hohlbaum, Maurice G Cary
Publikováno v:
Toxicologic Pathology. 49:235-260
The inhalation route is a relatively novel drug delivery route for biotherapeutics and, as a result, there is a paucity of published data and experience within the toxicology/pathology community. In recent years, findings arising in toxicology studie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::507bdc0e870c9ffe85569d58c5326be1
https://doi.org/10.1177/0192623320976094
https://doi.org/10.1177/0192623320976094
Autor:
Jochen Woicke, Muthafar M. Al-Haddawi, Jean-Guy Bienvenu, Jessica M. Caverly Rae, Franck J. Chanut, Karyn Colman, John M. Cullen, Wendell Davis, Ryo Fukuda, Maike Huisinga, Ursula Junker Walker, Kiyonori Kai, Ramesh C. Kovi, Nicholas P. Macri, Heike-Antje Marxfeld, Kristen J. Nikula, Ingrid D. Pardo, Thomas J. Rosol, Alok K. Sharma, Bhanu P. Singh, Kazutoshi Tamura, Michael S. Thibodeau, Enrico Vezzali, Justin D. Vidal, Emily K. Meseck
Publikováno v:
Toxicologic Pathology. 49:5-109
The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions) Project ( www.toxpath.org/inhand.asp ) is a joint initiative of the societies of toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff6c7853ca62350eb8e995507fa8b2e2
https://doi.org/10.1177/0192623320968181
https://doi.org/10.1177/0192623320968181
Publikováno v:
Toxicologic Pathology. 49:334-348
Afrezza delivers inhaled insulin using the Gen2 inhaler for the treatment of patients with type 1 and type 2 Diabetes. Afrezza was evaluated in long-term nonclinical pulmonary safety studies in 2 toxicology species. Chronic inhalation toxicology stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7fcab2fb356217ea065704281ffcdc6
https://doi.org/10.1177/0192623320960420
https://doi.org/10.1177/0192623320960420
Autor:
Jonathan M. Maher, Rui Zhang, Gopinath Palanisamy, Kimberly Perkins, Lynda Liu, Patrick Brassil, Alexander McNamara, Arthur Lo, Adam D. Hughes, Jitendra Kanodia, Svitlana Kulyk, Kristen J. Nikula, Hart S. Dengler, Amy Scandurra, Ingrid Lua, Eric Harstad
Publikováno v:
Toxicology and Applied Pharmacology. 438:115905
Systemic therapies targeting transforming growth factor beta (TGFβ) or TGFβR1 kinase (ALK5) have been plagued by toxicities including cardiac valvulopathy and bone physeal dysplasia in animals, posing a significant challenge for clinical developmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4606385857511b66512fdf43a79a65bf
https://doi.org/10.1016/j.taap.2022.115905
https://doi.org/10.1016/j.taap.2022.115905
Autor:
Luqi Pei, Stuart Cracknell, James D. Blanchard, Jeffrey S. Tepper, Philip J. Kuehl, Kristen J. Nikula
Publikováno v:
International Journal of Toxicology. 35:376-392
Developing inhaled drugs requires knowledge of lung anatomy, cell biology, respiratory physiology, particle physics, and some plumbing. Although dose makes the poison, in the context of an inhaled drug, the “dose” is not easily defined. This lack
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::784b1a9ecb2a715f9bf3bfccf8c9eab2
https://doi.org/10.1177/1091581815624080
https://doi.org/10.1177/1091581815624080
Autor:
Krystof S. Bankiewicz, Erich Mohr, Matthias Luz, H. Christian Fibiger, John Bringas, Diane E. Stockinger, Kristen J. Nikula, Chris Boiko, Philip C. Allen, Owen T. Lewis, Max Woolley
Publikováno v:
Archives of Toxicology
Archives of toxicology, vol 92, iss 7
Archives of toxicology, vol 92, iss 7
Glial cell line-derived neurotrophic factor (GDNF) has demonstrated neurorestorative and neuroprotective effects in rodent and nonhuman primate models of Parkinson’s disease. However, continuous intraputamenal infusion of GDNF (100 µg/day) resulte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbe0dbbe8156e443e12d653a0147f36e
https://pubmed.ncbi.nlm.nih.gov/29785638
https://pubmed.ncbi.nlm.nih.gov/29785638
Publikováno v:
Handbook of Toxicologic Pathology (Second Edition)
The respiratory tract is a complex organ system both macroscopically and microscopically, with many different functions and cell types located throughout the nasopharyngeal, tracheobronchial, and pulmonary regions. Exposure to xenobiotics occurs via
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2d9a1c64f1406575818c26dd6c0e5d1
https://doi.org/10.1016/b978-0-12-809841-7.00014-9
https://doi.org/10.1016/b978-0-12-809841-7.00014-9
Autor:
Timothy McGovern, Glen K. Miller, Kristen J. Nikula, Marielle Odin, Michael V. Pino, Matthew D. Reed, Jeffrey McCartney
Publikováno v:
Toxicologic Pathology. 42:472-486
The Scientific and Regulatory Policy Committee of the Society of Toxicologic Pathology (STP) appointed a working group to address risk assessment for increases in alveolar macrophages following inhalation of pharmaceutical materials. This position pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8ea26b85cc40395b982aa60f0087f56
https://doi.org/10.1177/0192623313507003
https://doi.org/10.1177/0192623313507003
Autor:
Kathleen A. Funk, Kristen J. Nikula
Publikováno v:
Toxicologic pathology. 44(1)
Necropsies conducted to support medical device development may be conducted in facilities that do not have the infrastructure in place to support Good Laboratory Practice for Nonclinical Laboratory Studies (GLP) studies and for a variety of reasons t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7f7862fd26b3b4d63e8aa218c0adc55
https://pubmed.ncbi.nlm.nih.gov/26656240
https://pubmed.ncbi.nlm.nih.gov/26656240
Publikováno v:
Experimental Lung Research. 30:1-15
B6C3F1 female mice were exposed to cigarette smoke (CS) (250 mg/m3 total particulate material) or filtered air (FA), 6 hours/day, 5 days/week, for 6, 7, or 10 weeks, or to CS for 6 weeks, then FA for 1 or 4 additional weeks. Exposure to CS increased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17e541eddadc31ef51f4b03a2e4b0db7
https://doi.org/10.1080/01902140490252858
https://doi.org/10.1080/01902140490252858