Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Kristen Evaul"'
2
Data from Abiraterone Inhibits 3β-Hydroxysteroid Dehydrogenase: A Rationale for Increasing Drug Exposure in Castration-Resistant Prostate Cancer
Autor: Nima Sharifi, Richard J. Auchus, Jiayan Liu, Jennifer Yoshimoto, Kai-Hsiung Chang, Kamalesh K. Sharma, Kristen Evaul, Rui Li
Purpose: Treatment with abiraterone (abi) acetate prolongs survival in castration-resistant prostate cancer (CRPC). Resistance to abi invariably occurs, probably due in part to upregulation of steroidogenic enzymes and/or other mechanisms that sustai
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::868d738e8b027c1a485d62e428f58bc8
https://doi.org/10.1158/1078-0432.c.6523172.v1
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4
Huntingtin-interacting protein 1 phosphorylation by receptor tyrosine kinases
Autor: Anmin A. Wang, Sha Huang, Chiron W. Graves, Heather M. Ames, Alanna Coughran, Theodora S. Ross, Abigail A. Soyombo, Kristen Evaul
Publikováno v: Molecular and cellular biology. 33(18)
Huntingtin-interacting protein 1 (HIP1) binds inositol lipids, clathrin, actin, and receptor tyrosine kinases (RTKs). HIP1 is elevated in many tumors, and its expression is prognostic in prostate cancer. HIP1 overexpression increases levels of the RT
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1373fe24c65e8501bf11757db9595e9
https://pubmed.ncbi.nlm.nih.gov/23836884
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5
3beta-hydroxysteroid dehydrogenase is a possible pharmacological target in the treatment of castration-resistant prostate cancer
Autor: Kristen Evaul, Rui Li, Mahboubeh Papari-Zareei, Richard J. Auchus, Nima Sharifi
Publikováno v: Endocrinology. 151(8)
Prostate cancer usually responds to androgen deprivation therapy, although the response in metastatic disease is almost always transient and tumors eventually progress as castration-resistant prostate cancer (CRPC). CRPC continues to be driven by tes
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::638adb4b49b7d925674ae85d6d152b66
https://pubmed.ncbi.nlm.nih.gov/20534728
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6
Nongenomic Steroid-Triggered Oocyte Maturation: Of Mice and Frogs
Autor: Michelle Jamnongjit, Kristen Evaul, Melissa Rasar, Stephen R. Hammes, James Deng, Liliana Carbajal
Luteinizing hormone (LH) mediates many important processes in ovarian follicles, including cumulus cell expansion, changes in gap junction expression and activity, sterol and steroid production, and the release of paracrine signaling molecules. All o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a189aa3a15d992be13333b57e2354c7
https://europepmc.org/articles/PMC2702721/
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7
Cross-talk between G Protein-coupled and Epidermal Growth Factor Receptors Regulates Gonadotropin-mediated Steroidogenesis in Leydig Cells*
Autor: Kristen Evaul, Stephen R. Hammes
Gonadal steroid production is stimulated by gonadotropin binding to G protein-coupled receptors (GPCRs). Although GPCR-mediated increases in intracellular cAMP are known regulators of steroidogenesis, the roles of other signaling pathways in mediatin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08419dd3e9d7a1044742444a1583f204
https://europepmc.org/articles/PMC2562062/
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8
Testosterone and progesterone rapidly attenuate plasma membrane Gbetagamma-mediated signaling in Xenopus laevis oocytes by signaling through classical steroid receptors
Autor: Kristen Evaul, Stephen R. Hammes, Michelle Jamnongjit, Bala Bhagavath
Publikováno v: Molecular endocrinology (Baltimore, Md.). 21(1)
Many transcription-independent (nongenomic) steroid effects are regulated by G proteins. A well-established, biologically relevant example of steroid/G protein interplay is steroid-triggered oocyte maturation, or meiotic resumption, in Xenopus laevis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4232829b83ae06a1532f0490248bd44
https://pubmed.ncbi.nlm.nih.gov/17021048
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