Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Kristen E. Rohli"'
Autor:
J. Jason Collier, Heidi M. Batdorf, Thomas M. Martin, Kristen E. Rohli, David H. Burk, Danhong Lu, Chris R. Cooley, Michael D. Karlstad, Joseph W. Jackson, Tim E. Sparer, Jingying Zhang, Randall L. Mynatt, Susan J. Burke
Publikováno v:
Molecular Metabolism, Vol 44, Iss , Pp 101140- (2021)
Objective: The expression of the interleukin-1 receptor type I (IL-1R) is enriched in pancreatic islet β-cells, signifying that ligands activating this pathway are important for the health and function of the insulin-secreting cell. Using isolated m
Externí odkaz:
https://doaj.org/article/1a3edd9950484f2c84401d8bd197de64
Publikováno v:
Biomolecules, Vol 12, Iss 2, p 335 (2022)
Pancreatic islet β-cells exhibit tremendous plasticity for secretory adaptations that coordinate insulin production and release with nutritional demands. This essential feature of the β-cell can allow for compensatory changes that increase secretor
Externí odkaz:
https://doaj.org/article/a80f3bcbd8324d9cadb0474fb8129f28
Autor:
Yuenan Liu, Kristen E. Rohli, Pengyue Shen, Shujuan Yang, Xiangyi Kong, Qingyu Dou, Haonan Lu, Yun Yin, Lin Zhang, Peng Jia
Publikováno v:
Primary Care Diabetes
This review comprehensively summarizes epidemiologic evidence of COVID-19 in patients with Type 2 diabetes, explores pathophysiological mechanisms, and integrates recommendations and guidelines for patient management. We found that diabetes was a ris
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e1211adc492cb6dd2deddbec3f446ac
https://doi.org/10.1016/j.pcd.2021.08.014
https://doi.org/10.1016/j.pcd.2021.08.014
Autor:
Kristen E Rohli, Cierra K Boyer, Shelby C Bearrows, Marshall R Moyer, Weston S Elison, Casey J Bauchle, Sandra E Blom, Jianchao Zhang, Yanzhuang Wang, Samuel B Stephens
Publikováno v:
Function (Oxford, England). 3(6)
Defects in the pancreatic β-cell’s secretion system are well-described in type 2 diabetes (T2D) and include impaired proinsulin processing and a deficit in mature insulin-containing secretory granules; however, the cellular mechanisms underlying t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba7228aa8ec7f2bcacabaa533e9c6145
https://pubmed.ncbi.nlm.nih.gov/36325514
https://pubmed.ncbi.nlm.nih.gov/36325514
Autor:
Anup Parchure, Meng Tian, Danièle Stalder, Cierra K. Boyer, Shelby C. Bearrows, Kristen E. Rohli, Jianchao Zhang, Felix Rivera-Molina, Bulat R. Ramazanov, Sushil K. Mahata, Yanzhuang Wang, Samuel B. Stephens, David C. Gershlick, Julia von Blume
Publikováno v:
The Journal of cell biology. 221(12)
Insulin is synthesized by pancreatic β-cells and stored into secretory granules (SGs). SGs fuse with the plasma membrane in response to a stimulus and deliver insulin to the bloodstream. The mechanism of how proinsulin and its processing enzymes are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c06ae34bba42fd697106ba5e38e87f4
https://pubmed.ncbi.nlm.nih.gov/36173346
https://pubmed.ncbi.nlm.nih.gov/36173346
Autor:
Anup Parchure, Meng Tian, Cierra K Boyer, Shelby C Bearrows, Kristen E Rohli, Jianchao Zhang, Bulat R Ramazanov, Yanzhuang Wang, Samuel B Stephens, Julia von Blume
Insulin is a key regulator of human metabolism, and its dysfunction leads to diseases such as type 2 diabetes. It remains unknown how proinsulin is targeted from the trans-Golgi network (TGN) to secretory storage granules as no cargo receptor has bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff841414aa48de51970171ebfedfb23e
https://doi.org/10.1101/2021.12.22.472607
https://doi.org/10.1101/2021.12.22.472607
Autor:
Cierra K. Boyer, Kristen E. Rohli, Marshall R. Moyer, Casey J. Bauchle, Weston S. Elison, Marshall R. Pope, Sandra E. Blom, Jianchao Zhang, Shelby C. Bearrows, Chi-Li Yu, Yanzhuang Wang, Samuel B. Stephens
Defects in the {beta}-cells secretion system are well-described in Type 2 diabetes (T2D), including reduced insulin storage and impaired proinsulin processing; however, the cellular mechanisms underlying these secretory defects and the contribution o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b4049364b29302ed299892d157306b5
https://doi.org/10.1101/2021.09.22.461417
https://doi.org/10.1101/2021.09.22.461417
Autor:
Siming Liu, Kristen E. Rohli, Jonathan V. Rocheleau, Yumi Imai, Vidhant Pal, Eric B. Taylor, Samuel B. Stephens, Cierra K. Boyer, Casey J. Bauchle
Publikováno v:
Diabetes
The defining feature of pancreatic islet β-cell function is the precise coordination of changes in blood glucose levels with insulin secretion to regulate systemic glucose homeostasis. While ATP has long been heralded as a critical metabolic couplin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f48405d6238ce5eed87cc25ce6da3af
https://europepmc.org/articles/PMC8385611/
https://europepmc.org/articles/PMC8385611/
Autor:
Weiqi Zhou, Yanan Ma, Chao Yu, Xiongfeng Pan, Peng Jia, Shaoqing Dai, Kristen E. Rohli, Robert V. Rohli
Publikováno v:
Obesity reviews, 22(S1):e13097. Wiley-Blackwell
Obesity Reviews
Obesity Reviews
Summary The associations between built and food environments and childhood obesity have been studied extensively. However, the association between the natural environment and childhood obesity has received too little scholarly attention. This study r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::583281a1b29ba5ed62c4c4f719bd4aa7
https://doi.org/10.1111/obr.13097
https://doi.org/10.1111/obr.13097
Publikováno v:
Journal of Diabetes and Its Complications
Journal of Diabetes and its Complications
Journal of Diabetes and its Complications
With the increasing prevalence of obesity, there is a growing awareness of its impact on infectious diseases. In past epidemics of influenza A and Middle East respiratory syndrome (MERS) coronavirus, obesity has been identified as a risk factor influ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8ad387a72a0ff11b7d2287a88c8f371
https://pubmed.ncbi.nlm.nih.gov/33358523
https://pubmed.ncbi.nlm.nih.gov/33358523