Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Kristen E. Mengwasser"'
Autor:
Jessica S. Elman, Thomas K. Ni, Kristen E. Mengwasser, Dexter Jin, Ania Wronski, Stephen J. Elledge, Charlotte Kuperwasser
Publikováno v:
Cell Reports, Vol 28, Iss 13, Pp 3435-3449.e5 (2019)
Summary: Comprehensive sequencing approaches have allowed for the identification of the most frequent contributors to cancer, known as drivers. They have also revealed a class of mutations in understudied, infrequently altered genes, referred to as
Externí odkaz:
https://doaj.org/article/e617fd7258c847d486aa6bcbaa90f6f9
Autor:
Stephen J. Elledge, Camilla L. Christensen, Anthony Anselmo, Jingjing Duan, Kwok-Kin Wong, Kristopher T. Kahle, Mamie Z. Li, Ting Chen, Kristen E. Mengwasser, Teresa Davoli, Eric C. Wooten
Publikováno v:
Genes & Development
Activating mutations in the phosphoinositide 3-kinase (PI3K) signaling pathway are frequently identified in cancer. To identify pathways that support PI3K oncogenesis, we performed a genome-wide RNAi screen in isogenic cell lines harboring wild-type
Autor:
Kristen E. Mengwasser, Richard O. Adeyemi, Mei Yuk Choi, Connor Clairmont, Yumei Leng, Stephen J. Elledge, Alan D. D'Andrea
BRCA1 or BRCA2 inactivation drives breast and ovarian cancer but also creates vulnerability to poly(ADP-ribose) polymerase (PARP) inhibitors. To search for additional targets whose inhibition is synthetically lethal in BRCA2-deficient backgrounds, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a77779d799d2b9f49f549a9641300dc
https://europepmc.org/articles/PMC6892393/
https://europepmc.org/articles/PMC6892393/
Autor:
Stephen J. Elledge, Charlotte Kuperwasser, Ania Wronski, Dexter X. Jin, Jessica S Elman, Kristen E. Mengwasser, Thomas K. Ni
Publikováno v:
Cell reports
Cell Reports, Vol 28, Iss 13, Pp 3435-3449.e5 (2019)
Cell Reports, Vol 28, Iss 13, Pp 3435-3449.e5 (2019)
SUMMARY Comprehensive sequencing approaches have allowed for the identification of the most frequent contributors to cancer, known as drivers. They have also revealed a class of mutations in understudied, infrequently altered genes, referred to as
Autor:
John C. Yoon, Laura M. Sack, Kristen E. Mengwasser, Andrew Wei Xu, Teresa Davoli, Stephen J. Elledge, Peter J. Park
Publikováno v:
Cell. 155:948-962
SummaryAneuploidy has been recognized as a hallmark of cancer for more than 100 years, yet no general theory to explain the recurring patterns of aneuploidy in cancer has emerged. Here, we develop Tumor Suppressor and Oncogene (TUSON) Explorer, a com
Autor:
Kristen E. Mengwasser, Michele S. Woo, Heidi Greulich, Angela V. Toms, Matthew Meyerson, Kwok-Kin Wong, Cai-Hong Yun, Michael J. Eck
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 105(6)
Lung cancers caused by activating mutations in the epidermal growth factor receptor (EGFR) are initially responsive to small molecule tyrosine kinase inhibitors (TKIs), but the efficacy of these agents is often limited because of the emergence of dru
Publikováno v:
The Journal of biological chemistry. 280(29)
Thrombin exists in two allosteric forms, slow (S) and fast (F), that recognize natural substrates and inhibitors with significantly different affinities. Because under physiologic conditions the two forms are almost equally populated, investigation o
Publikováno v:
Protein Expression and Purification
Myeloid differentiation proteins MD-1 and MD-2 have both been shown to form a heterogeneous collection of oligomers when expressed in absence of their respective receptor, RP105 and TLR4. The biological relevance of these oligomers is not clear. Only