Crowdsourced mapping of unexplored target space of kinase inhibitors

Autor: Anna Cichońska, Balaguru Ravikumar, Robert J. Allaway, Fangping Wan, Sungjoon Park, Olexandr Isayev, Shuya Li, Michael Mason, Andrew Lamb, Ziaurrehman Tanoli, Minji Jeon, Sunkyu Kim, Mariya Popova, Stephen Capuzzi, Jianyang Zeng, Kristen Dang, Gregory Koytiger, Jaewoo Kang, Carrow I. Wells, Timothy M. Willson, The IDG-DREAM Drug-Kinase Binding Prediction Challenge Consortium, Tudor I. Oprea, Avner Schlessinger, David H. Drewry, Gustavo Stolovitzky, Krister Wennerberg, Justin Guinney, Tero Aittokallio

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)

The IDG-DREAM Challenge carried out crowdsourced benchmarking of predictive algorithms for kinase inhibitor activities on unpublished data. This study provides a resource to compare emerging algorithms and prioritize new kinase activities to accelera

Externí odkaz: https://doaj.org/article/f21e267a1ae047ee9c1ecdf221b76214

Combining accurate tumor genome simulation with crowdsourcing to benchmark somatic structural variant detection

Autor: Anna Y. Lee, Adam D. Ewing, Kyle Ellrott, Yin Hu, Kathleen E. Houlahan, J. Christopher Bare, Shadrielle Melijah G. Espiritu, Vincent Huang, Kristen Dang, Zechen Chong, Cristian Caloian, Takafumi N. Yamaguchi, ICGC-TCGA DREAM Somatic Mutation Calling Challenge Participants, Michael R. Kellen, Ken Chen, Thea C. Norman, Stephen H. Friend, Justin Guinney, Gustavo Stolovitzky, David Haussler, Adam A. Margolin, Joshua M. Stuart, Paul C. Boutros

Publikováno v: Genome Biology, Vol 19, Iss 1, Pp 1-15 (2018)

Abstract Background The phenotypes of cancer cells are driven in part by somatic structural variants. Structural variants can initiate tumors, enhance their aggressiveness, and provide unique therapeutic opportunities. Whole-genome sequencing of tumo

Externí odkaz: https://doaj.org/article/fca34c67ffed4790a306c9523e251762

Publisher Correction: Gene expression imputation across multiple brain regions provides insights into schizophrenia risk

Autor: Nancy Buccola, Jonas Bybjerg-Grauholm, Sarah TOSATO, Christos Pantelis, James Walters, Igor Nenadić, Joseph Buxbaum, Thanneer Malai Perumal, Miloš Milovančević, Naomi Wray, Silviu-Alin Bacanu, Danielle Posthuma, Inez Myin-Germeys, Francis Anthony O'Neill, Sang Hong Lee, Kristen Dang, Peter Visscher, Tracey Petryshen, Esben Agerbo, Jianjun Liu, Engilbert Sigurdsson, Sara Marsal, Robert Freedman, Donald Black, Fritz Zimprich, Clement C Zai, Nakao IWATA, Elvira Bramon, Masashi Ikeda, Andrew McIntosh, Bryan Mowry, Patrik Magnusson, Janis Klovins, Thomas D. Als, Ulrich Schall, Milica Pejovic Milovancevic, Kang Sim, Rodney Scott, Anders Børglum, Jennifer Moran, Merete Nordentoft, Jakob Grove, Sergi Papiol, Bradley Webb, Elisabeth Stögmann

Publikováno v: Nature Genetics, 51(6), 1068-1068. Nature Publishing Group
iPSYCH-GEMS Schizophrenia Working Group, CommonMind Consortium & The Schizophrenia Working Group of the Psychiatric Genomics Consortium 2019, ' Publisher Correction: Gene expression imputation across multiple brain regions provides insights into schizophrenia risk ', Nature Genetics, vol. 51, no. 6, pp. 1068-1068 . https://doi.org/10.1038/s41588-019-0435-6

In the HTML version of the article originally published, the author group ‘The Schizophrenia Working Group of the Psychiatric Genomics Consortium’ was displayed incorrectly. The error has been corrected in the HTML version of the article.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c7437141fdb3b6da722ee8b0e3d1e17
https://doi.org/10.1038/s41588-019-0435-6

The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses

Autor: Kristen Dang, Masayuki Kitajima, Thomas A. Stoklasek, Bryan D. Bell, Kazuhito Sakamoto, Steven F. Ziegler, Kay Uwe Wagner, Boris Reizis, Ryan P. Larson, Lothar Hennighausen

Publikováno v: Nature immunology

Dendritic cells (DCs) are critical in immune responses, linking innate and adaptive immunity. We found here that DC-specific deletion of the transcription factor STAT5 was not critical for development but was required for T helper type 2 (TH2), but n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be3b49764831fda5d61227032b412a25
https://pubmed.ncbi.nlm.nih.gov/23435120