Výsledky vyhledávání - "Kristen Carraway"

Akademický článek

n-3 PUFA improves fatty acid composition, prevents palmitate-induced apoptosis, and differentially modifies B cell cytokine secretion in vitro and ex vivo

Autor: Benjamin Drew Rockett, Muhammad Salameh, Kristen Carraway, Kaitlin Morrison, Saame Raza Shaikh

Publikováno v: Journal of Lipid Research, Vol 51, Iss 6, Pp 1284-1297 (2010)

n-3 polyunsaturated fatty acids (PUFAs) modify T-cell activation, in part by remodeling lipid composition; however, the relationship between n-3 PUFA and B-cell activation is unknown. Here we tested this relationship in vitro and ex vivo by measuring

Externí odkaz: https://doaj.org/article/2dead4050b2d4b869c9285aeea9f74ef

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N6-methyladenosine contributes to cellular phenotype in a genetically-defined model of breast cancer progression

Autor: Olga Ilkayeva, Kyle D. Mansfield, Kristen Carraway, Nate J. Fry, Christopher L. Holley, Brittany A. Law

Publikováno v: Oncotarget. 9:31231-31243

The mRNA modification N6-methyladenosine (m6A) is involved in many post-transcriptional regulatory processes including mRNA stability and translational efficiency. However, it is also imperative to correlate these processes with phenotypic outputs du

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bb6c3eab5405b6fc702612559f5e0740
https://doi.org/10.18632/oncotarget.25782

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Characterization of METTL16 as a cytoplasmic RNA binding protein

Autor: Emily R. Satterwhite, Kristen Carraway, Daniel J. Nance, Brinda Bhaskar, Sway Misra, Kyle D. Mansfield

Publikováno v: PLoS ONE
PLoS ONE, Vol 15, Iss 1, p e0227647 (2020)

mRNA modification by N6-methyladenosine (m6A) is involved in many post-transcriptional regulation processes including mRNA stability, splicing and promotion of translation. Accordingly, the recently identified mRNA methylation complex containing METT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ced098f3b820fdd5be02ddbe89b8a3e
https://doi.org/10.1371/journal.pone.0227647

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Hypoxic stabilization of mRNA is HIF-independent but requires mtROS

Autor: Kyle D. Mansfield, Brinda Sarathy, Grey W Fortenbery, Kristen Carraway

Publikováno v: Cellular & Molecular Biology Letters
Cellular & Molecular Biology Letters, Vol 23, Iss 1, Pp 1-15 (2018)

Background Tissue ischemia can arise in response to numerous physiologic and pathologic conditions. The cellular response to decreased perfusion, most notably a decrease in glucose and oxygen, is important for cellular survival. In response to oxygen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c62f266a707cfbeec5e16b9eec77047
https://pubmed.ncbi.nlm.nih.gov/30305827

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Hypoxia and Hypoglycemia synergistically regulate mRNA stability

Autor: Kristen Carraway, Kyle D. Mansfield, Travis C Kauffmann, Ellen M Johnson, Nate J. Fry

Publikováno v: RNA Biology

Ischemic events, common in many diseases, result from decreased blood flow and impaired delivery of oxygen and glucose to tissues of the body. While much is known about the cellular transcriptional response to ischemia, much less is known about the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48a54ddaa81efa7bfc112f2ef8f40c2b
https://pubmed.ncbi.nlm.nih.gov/28362162

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Aldehyde stress and up-regulation of Nrf2-mediated antioxidant systems accompany functional adaptations in cardiac mitochondria from mice fed n−3 polyunsaturated fatty acids

Autor: Kathleen Thayne, Mitchel Harris, Saame Raza Shaikh, Ethan J. Anderson, Kristen Carraway

Publikováno v: Biochemical Journal. 441:359-366

Diets replete with n−3 PUFAs (polyunsaturated fatty acids) are known to have therapeutic potential for the heart, although a specifically defined duration of the n−3 PUFA diet required to achieve these effects remains unknown, as does their mecha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8893af93ade367ba88aa6ed5e973a403
https://doi.org/10.1042/bj20110626

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Rapid pyrophosphate release from transcriptional elongation complexes appears to be coupled to a nucleotide-induced conformational change in E. coli core polymerase

Autor: Mark Strausbauch, Ronald S. Johnson, J. Kristen Carraway

Publikováno v: Journal of molecular biology. 412(5)

In the nucleotide addition cycle, pyrophosphate is generated upon incorporation of each nucleotide. Rapid release of pyrophosphate is essential for facile transcription elongation. Stopped-flow kinetic studies involving alterations in the intrinsic p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4d8dcf094d842d2093808c9288aea82
https://pubmed.ncbi.nlm.nih.gov/21624374

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