Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Kristen C, Thomas"'
Autor:
Marshall W. Hogarth, Peter J. Houweling, Kristen C. Thomas, Heather Gordish-Dressman, Luca Bello, Cooperative International Neuromuscular Research Group (CINRG), Elena Pegoraro, Eric P. Hoffman, Stewart I. Head, Kathryn N. North
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Duchenne muscular dystrophy is a disease caused by a single gene, characterized by progressive muscle weakness, but is variable between patients partly due to interactions of other genes. Here, the authors show that a commonACTN3polymorphism can modi
Externí odkaz:
https://doaj.org/article/818c34e56abe46399fd41cf88d337f97
Autor:
Maximilian Kleinert, Benjamin L. Parker, Rima Chaudhuri, Daniel J. Fazakerley, Annette Serup, Kristen C. Thomas, James R. Krycer, Lykke Sylow, Andreas M. Fritzen, Nolan J. Hoffman, Jacob Jeppesen, Peter Schjerling, Markus A. Ruegg, Bente Kiens, David E. James, Erik A. Richter
Publikováno v:
Molecular Metabolism, Vol 5, Iss 8, Pp 646-655 (2016)
Objective: We have recently shown that acute inhibition of both mTOR complexes (mTORC1 and mTORC2) increases whole-body lipid utilization, while mTORC1 inhibition had no effect. Therefore, we tested the hypothesis that mTORC2 regulates lipid metaboli
Externí odkaz:
https://doaj.org/article/db4cfad4b24e438e88473b12dcfae495
Autor:
Daniel J Fazakerley, Rima Chaudhuri, Pengyi Yang, Ghassan J Maghzal, Kristen C Thomas, James R Krycer, Sean J Humphrey, Benjamin L Parker, Kelsey H Fisher-Wellman, Christopher C Meoli, Nolan J Hoffman, Ciana Diskin, James G Burchfield, Mark J Cowley, Warren Kaplan, Zora Modrusan, Ganesh Kolumam, Jean YH Yang, Daniel L Chen, Dorit Samocha-Bonet, Jerry R Greenfield, Kyle L Hoehn, Roland Stocker, David E James
Publikováno v:
eLife, Vol 7 (2018)
Insulin resistance in muscle, adipocytes and liver is a gateway to a number of metabolic diseases. Here, we show a selective deficiency in mitochondrial coenzyme Q (CoQ) in insulin-resistant adipose and muscle tissue. This defect was observed in a ra
Externí odkaz:
https://doaj.org/article/8a5796fc74b24c25b9c3c989e6b15e61
Autor:
Rachael Fletcher, Christopher Gribben, Xiuquan Ma, James G Burchfield, Kristen C Thomas, James R Krycer, David E James, Daniel J Fazakerley
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95598 (2014)
The Niemann-Pick disease, type C1 (NPC1) gene encodes a transmembrane protein involved in cholesterol efflux from the lysosome. SNPs within NPC1 have been associated with obesity and type 2 diabetes, and mice heterozygous or null for NPC1 are insulin
Externí odkaz:
https://doaj.org/article/bc28627d325f4b2eb2736832c82d3e5f
Autor:
Kristen C Thomas, Xi Fiona Zheng, Francia Garces Suarez, Joanna M Raftery, Kate G R Quinlan, Nan Yang, Kathryn N North, Peter J Houweling
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88653 (2014)
The ability to obtain accurate and reproducible data using quantitative real-time Polymerase Chain Reaction (RT-qPCR) is limited by the process of data normalization. The use of 'housekeeping' or 'reference' genes is the most common technique used to
Externí odkaz:
https://doaj.org/article/89b004ca902647d399c82759a23cdbcb
Autor:
James G. Burchfield, James R. Krycer, Rachael Fletcher, Xuiquan Ma, Kristen C. Thomas, Christopher Gribben, Daniel J. Fazakerley, David E. James
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 4, p e95598 (2014)
PLoS ONE, Vol 9, Iss 4, p e95598 (2014)
The Niemann-Pick disease, type C1 (NPC1) gene encodes a transmembrane protein involved in cholesterol efflux from the lysosome. SNPs within NPC1 have been associated with obesity and type 2 diabetes, and mice heterozygous or null for NPC1 are insulin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3101652e286e468c63431d16110fb76f
Autor:
P. Tess Whitworth, Ee Cheng Khor, Kyle L. Hoehn, Xiuquan Ma, James Cantley, Belinda Yau, Christopher C. Meoli, James G. Burchfield, Natalie K.Y. Wee, Jacqueline Stöckli, James R. Krycer, Shi-Xlong Tan, Annabel Y. Minard, Paul A. Baldock, Nolan J. Hoffman, Daniel J. Fazakerley, Marin E. Nelson, Trevor J. Biden, Gregory J. Cooney, Amanda L. Wright, Ronaldo F. Enriquez, Melkam A. Kebede, Kristen C. Thomas, David E. James, Bryce Vissel
© 2018 by The American Society for Biochemistry and Molecular Biology, Inc. Obesity is associated with metabolic dysfunction, including insulin resistance and hyperinsulinemia, and with disorders such as cardiovascular disease, osteoporosis, and neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c71f02bc8840d707632c2abc83e61c6c
https://acuresearchbank.acu.edu.au/item/8qx48/high-dietary-fat-and-sucrose-results-in-an-extensive-and-time-dependent-deterioration-in-health-of-multiple-physiological-systems-in-mice
https://acuresearchbank.acu.edu.au/item/8qx48/high-dietary-fat-and-sucrose-results-in-an-extensive-and-time-dependent-deterioration-in-health-of-multiple-physiological-systems-in-mice
Autor:
Kyle L. Hoehn, Jerry R. Greenfield, Warren Kaplan, Ganesh Kolumam, James G. Burchfield, David E. James, Nolan J. Hoffman, Daniel L. T Chen, Jean Yh Yang, Ciana Diskin, Kelsey H. Fisher-Wellman, Sean J. Humphrey, Ghassan J. Maghzal, Kristen C. Thomas, Benjamin L. Parker, James R. Krycer, Zora Modrusan, Rima Chaudhuri, Roland Stocker, Daniel J. Fazakerley, Pengyi Yang, Dorit Samocha-Bonet, Christopher C. Meoli, Mark J. Cowley
Publikováno v:
eLife, Vol 7 (2018)
eLife
eLife
Insulin resistance in muscle, adipocytes and liver is a gateway to a number of metabolic diseases. Here, we show a selective deficiency in mitochondrial coenzyme Q (CoQ) in insulin-resistant adipose and muscle tissue. This defect was observed in a ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3f4f9362349b13b51a6a6ef1d39528a
https://acuresearchbank.acu.edu.au/item/8q630/mitochondrial-coq-deficiency-is-a-common-driver-of-mitochondrial-oxidants-and-insulin-resistance
https://acuresearchbank.acu.edu.au/item/8q630/mitochondrial-coq-deficiency-is-a-common-driver-of-mitochondrial-oxidants-and-insulin-resistance
Autor:
Christopher C. Meoli, James G. Burchfield, Sheyda Naghiloo, Matthew J. Prior, Daniel J. Fazakerley, Benjamin L. Parker, Jacqueline Stöckli, Rima Chaudhuri, David E. James, Beverley A. Murrow, Geoffrey D. Holman, James R. Krycer, Kristen C. Thomas, Francoise Koumanov
Publikováno v:
The Journal of Biological Chemistry
Background: We searched for novel regulators of insulin-stimulated glucose transport in adipocytes. Results: Tumor suppressor candidate 5 (TUSC5) colocalized with GLUT4, and manipulation of TUSC5 expression levels affected insulin-regulated glucose t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4279b46ef8cebac018eec3bec47ba458
http://europepmc.org/articles/PMC4583025
http://europepmc.org/articles/PMC4583025
Autor:
Daniel J Fazakerley, Rima Chaudhuri, Pengyi Yang, Ghassan J Maghzal, Kristen C Thomas, James R Krycer, Sean J Humphrey, Benjamin L Parker, Kelsey H Fisher-Wellman, Christopher C Meoli, Nolan J Hoffman, Ciana Diskin, James G Burchfield, Mark J Cowley, Warren Kaplan, Zora Modrusan, Ganesh Kolumam, Jean YH Yang, Daniel L Chen, Dorit Samocha-Bonet, Jerry R Greenfield, Kyle L Hoehn, Roland Stocker, David E James
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd9dfd56169a522c67aa9961c46fd768
https://doi.org/10.7554/elife.32111.032
https://doi.org/10.7554/elife.32111.032