Výsledky vyhledávání - "Kristen Bushell"

1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles

Autor: Hengjun He, Billy R. Martin, John W. Huffman, Michael P. Cassidy, Dana E. Selley, Kristen Bushell, Paul V. Szklennik, Amanda Almond, Jenny L. Wiley

Publikováno v: Bioorganicmedicinal chemistry letters. 15(18)

A new class of cannabimimetic indoles, with 3-phenylacetyl or substituted 3-phenylacetyl substituents, has been prepared and their affinities for the cannabinoid CB1 and CB2 receptors have been determined. In general those compounds with a 2-substi-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6d71c42561184fef15fb51867574163
https://pubmed.ncbi.nlm.nih.gov/16005223

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Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2) receptor agonists

Autor: Simon M. Bushell, Ming-Jung Wu, George Hynd, Dow P. Hurst, Billy R. Martin, Dana E. Selley, Gulay Zengin, Jianzhong Lu, Patricia H. Reggio, Cindy Tartal, John W. Huffman, Jenny L. Wiley, Kristen Bushell, Alicia L. S. Thompson, Michael P. Cassidy

Publikováno v: Bioorganicmedicinal chemistry. 13(1)

In an effort to improve indole-based CB(2) cannabinoid receptor ligands and also to develop SAR for both the CB(1) and CB(2) receptors, 47 indole derivatives were prepared and their CB(1) and CB(2) receptor affinities were determined. The indole deri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ce67e38e9637a0ccb70932cb936b954
https://pubmed.ncbi.nlm.nih.gov/15582455

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