Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Kristen A. Wieghaus"'
Autor:
Edward A. Botchwey, Richard J. Price, Kristen A. Wieghaus, Ji Song, Meghan M. Nickerson, Casey W. Shuptrine
Publikováno v:
Journal of Biomedical Materials Research Part A. :317-323
Poly(D,L-lactic-co-glycolic acid) (PLGA) is a biodegradable polymer that is widely used for drug delivery. However, the degradation of PLGA alters the local microenvironment and may influence tissue structure and/or function. Here, we studied whether
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdc351b4d9a06c75f09bd17db72563c0
https://doi.org/10.1002/jbm.a.32209
https://doi.org/10.1002/jbm.a.32209
Autor:
Caren E. Petrie Aronin, Meghan M. Nickerson, Edward A. Botchwey, Richard J. Price, Mikell Paige, Kristen A. Wieghaus, Lauren S. Sefcik, Milton L. Brown
Publikováno v:
Biomaterials. 29:4698-4708
Phthalimide neovascular factor (PNF1, formerly SC-3-149) is a potent stimulator of proangiogenic signaling pathways in endothelial cells. In this study, we evaluated the in vivo effects of sustained PNF1 release to promote ingrowth and expansion of m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27e498e5cafa4bae8463ee12cce0cd98
https://doi.org/10.1016/j.biomaterials.2008.08.029
https://doi.org/10.1016/j.biomaterials.2008.08.029
Autor:
Edward A. Botchwey, Jason A. Papin, Erwin P. Gianchandani, Milton L. Brown, Kristen A. Wieghaus
Publikováno v:
Tissue Engineering. 13:2561-2575
Neovascularization is essential for the survival and successful integration of most engineering tissues after implantation in vivo. The objective of this study was to elucidate possible mechanisms of phthalimide neovascular factor 1 (PNF1), a new syn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f27a851ab9a90eedb960dd3e20d7f13
https://doi.org/10.1089/ten.2007.0023
https://doi.org/10.1089/ten.2007.0023
Publikováno v:
Nanotechnology and Regenerative Engineering ISBN: 9781466585379
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef0f4305087d8f28997f76a6cb42d2e3
https://doi.org/10.1201/b17444-19
https://doi.org/10.1201/b17444-19
Autor:
Milton L. Brown, Edward A. Botchwey, Rebekah A. Neal, Kristen A. Wieghaus, Erwin P. Gianchandani, Mikell Paige, Jason A. Papin
Publikováno v:
Biotechnology and bioengineering. 103(4)
We are creating synthetic pharmaceuticals with angiogenic activity and potential to promote vascular invasion. We previously demonstrated that one of these molecules, phthalimide neovascular factor 1 (PNF1), significantly expands microvascular networ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a39badf8c7adccdabd9f09bc29cef2e
https://pubmed.ncbi.nlm.nih.gov/19326468
https://pubmed.ncbi.nlm.nih.gov/19326468
Autor:
Kristen A. Wieghaus, Jason A. Papin, Erwin P. Gianchandani, Mikell Paige, Milton L. Brown, Edward A. Botchwey
Motivation: Computational techniques have been applied to experimental datasets to identify drug mode-of-action. A shortcoming of existing approaches is the requirement of large reference databases of compound expression profiles. Here, we developed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3080ac057a6e9484f03609528216acf9
https://europepmc.org/articles/PMC2562016/
https://europepmc.org/articles/PMC2562016/
Publikováno v:
Biomaterials. 29(19)
Sphingosine 1-phosphate (S1P) is a bioactive phospholipid that impacts migration, proliferation, and survival in diverse cell types, including endothelial cells, smooth muscle cells, and osteoblast-like cells. In this study, we investigated the effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec0a1d4f46aa1b352269e44000b21368
https://pubmed.ncbi.nlm.nih.gov/18405965
https://pubmed.ncbi.nlm.nih.gov/18405965
Autor:
Christopher R. Anderson, Edward A. Botchwey, Milton L. Brown, Brett R. Blackman, Scott M. Capitosti, Kristen A. Wieghaus, Richard J. Price
Publikováno v:
Tissue engineering. 12(7)
Engineering of implantable tissues requires rapid induction of angiogenesis to meet the significant oxygen and nutrient demands of cells during tissue repair. To this end, our laboratories have utilized medicinal chemistry to synthesize non-peptide-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0229c738995f80685f63800a80198ce6
https://pubmed.ncbi.nlm.nih.gov/16889520
https://pubmed.ncbi.nlm.nih.gov/16889520
Publikováno v:
Langmuir : the ACS journal of surfaces and colloids. 21(1)
A direct comparison of surface loading, interface shear strength, and interface hydrolytic stability was made between a phosphonate and two siloxane monolayers formed on the native oxide surface of Ti-6Al-4V. Surface loading for the phosphonate was c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec12c3e75e480e7cae9ae92d2e6df819
https://pubmed.ncbi.nlm.nih.gov/15620307
https://pubmed.ncbi.nlm.nih.gov/15620307
Publikováno v:
MRS Proceedings. 845
Induction of angiogenesis is necessary for the success of engineered implantable tissues in order to meet oxygen and nutrient requirements of cells during tissue repair. Insufficient vascularization in bone graft reconstruction may impede healing and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c396cb75a031de23b822c994515e656
https://doi.org/10.1557/proc-845-aa5.47
https://doi.org/10.1557/proc-845-aa5.47