Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Kristen A Baltgalvis"'
Autor:
Wei Li, Mark D Claypool, Annabelle M Friera, John McLaughlin, Kristen A Baltgalvis, Ira J Smith, Taisei Kinoshita, Kathy White, Wayne Lang, Guillermo Godinez, Donald G Payan, Todd M Kinsella
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94032 (2014)
Numerous human diseases can lead to atrophy of skeletal muscle, and loss of this tissue has been correlated with increased mortality and morbidity rates. Clinically addressing muscle atrophy remains an unmet medical need, and the development of precl
Externí odkaz:
https://doaj.org/article/408c765604924646b1fef41e484a25ef
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e10164 (2010)
Estrogens are associated with the loss of skeletal muscle strength in women with age. Ovarian hormone removal by ovariectomy in mice leads to a loss of muscle strength, which is reversed with 17beta-estradiol replacement. Aging is also associated wit
Externí odkaz:
https://doaj.org/article/740b78ff5fec4771914d474094c1ee31
Autor:
Kevin J Sonnemann, Hanke Heun-Johnson, Amy J Turner, Kristen A Baltgalvis, Dawn A Lowe, James M Ervasti
Publikováno v:
PLoS Medicine, Vol 6, Iss 5, p e1000083 (2009)
The loss of dystrophin compromises muscle cell membrane stability and causes Duchenne muscular dystrophy and/or various forms of cardiomyopathy. Increased expression of the dystrophin homolog utrophin by gene delivery or pharmacologic up-regulation h
Externí odkaz:
https://doaj.org/article/4fdad23a597c44f7b801c8d249d2427a
Autor:
John T. Olthoff, Angus Lindsay, Reem Abo-Zahrah, Kristen A. Baltgalvis, Xiaobai Patrinostro, Joseph J. Belanto, Dae-Yeul Yu, Benjamin J. Perrin, Daniel J. Garry, George G. Rodney, Dawn A. Lowe, James M. Ervasti
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
In the mdx mouse model of Duchenne muscular dystrophy, muscle contractions lead to force loss, which is attributed to myofibre damage. Here, the authors show that force loss is instead mediated by a redox circuit involving NOX2, PROX1, myoglobin and
Externí odkaz:
https://doaj.org/article/223d776794074fb79b1d4e9d6b3d3b4f
Autor:
Kristen A. Baltgalvis, Vincent M. Crowley, Michael A. Schafroth, Brian E. Nordin, Benjamin F. Cravatt, Christie L Eissler, Joe L Rodriguez, Shota Kikuchi, Xiaoyu Zhang, Thomas G Wucherpfennig, Todd Kinsella, Kent T Symons, Melissa M. Dix, David S. Weinstein, Dean Stamos, Gabriel M. Simon, Yu Yamashita, Ludwig Bauer, Lena M Luukkonen
Publikováno v:
J Am Chem Soc
Ligand-induced protein degradation has emerged as a compelling approach to promote the targeted elimination of proteins from cells by directing these proteins to the ubiquitin-proteasome machinery. So far, only a limited number of E3 ligases have bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9801b3a3bafd3e374259ca9ad1a1524
https://doi.org/10.1021/jacs.1c00990
https://doi.org/10.1021/jacs.1c00990
Autor:
Wei Li, John McLaughlin, Donald G. Payan, Rajinder Singh, Nan Lin, Simon J. Shaw, Kristen A. Baltgalvis, Todd Kinsella, Dane Goff
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:2617-2621
A structure-activity relationship has been developed around the meridianin scaffold for inhibition of Dyrk1a. The compounds have been focussed on the inhibition of kinase Dyrk1a, as a means to retain the transcription factor NFAT in the nucleus. NFAT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee3030de6fb74eee3df8385505a77e46
https://doi.org/10.1016/j.bmcl.2017.03.037
https://doi.org/10.1016/j.bmcl.2017.03.037
Autor:
Christie L Eissler, Todd Kinsella, Gabe Simon, Colin Walsh, Joseph Klebba, Joel Chick, Ali Tabatabaei, Lena M Luukkonen, Landon Whitby, Kent T Symons, Kristen A. Baltgalvis, Yuta Naro, Matthew P. Patricelli, Larry Burgess, Dean Stamos, Joon Chang, Shota Kikuchi, Jaclyn Brannon, Charles Chapman, Brian E. Nordin
Publikováno v:
Cancer Research. 80:6411-6411
Introduction: Targeted protein degradation is a novel therapeutic modality that holds great promise. Current bispecific degraders have been mostly built using reversible ligands against two well characterized E3 ligases, CRBN and VHL. Features unique
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fd8700abc857dc43915d725ae6b6f54
https://doi.org/10.1158/1538-7445.am2020-6411
https://doi.org/10.1158/1538-7445.am2020-6411
Autor:
Benjamin J. Perrin, Kristen A. Baltgalvis, Angus Lindsay, John T. Olthoff, James M. Ervasti, Xiaobai Patrinostro, Dae Yeul Yu, Reem Abo-Zahrah, Dawn A. Lowe, George G. Rodney, Daniel J. Garry, Joseph J. Belanto
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Force loss in skeletal muscle exposed to eccentric contraction is often attributed to injury. We show that EDL muscles from dystrophin-deficient mdx mice recover 65% of lost force within 120 min of eccentric contraction and exhibit minimal force loss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e93688b51938ad633088780670072b2
https://doi.org/10.1038/s41467-018-07639-3
https://doi.org/10.1038/s41467-018-07639-3
Autor:
Allison M. Kosir, Angela G. Greising, Tara L. Mader, Dawn A. Lowe, Kristen A. Baltgalvis, Susan A. Novotny
Publikováno v:
Medicine & Science in Sports & Exercise. 47:1177-1187
The primary objective of this study was to determine whether strength loss and recovery after eccentric contractions are impaired in healthy and dystrophic female mice with low levels of ovarian hormones.Female C57BL/6 (wild-type) or mdx mice were ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df4e9b657c8e2b27898aa4a69d38cb9a
https://doi.org/10.1249/mss.0000000000000531
https://doi.org/10.1249/mss.0000000000000531
Autor:
Dawn A. Lowe, Jarrod A. Call, Zhen Yan, Rhianna C. Laker, Gregory D. Cochrane, Kristen A. Baltgalvis
Publikováno v:
Medicine & Science in Sports & Exercise. 44:1671-1679
Exercise is recommended for adults to prevent, reverse, or slow the progression of various chronic diseases including but not limited to cardiovascular disease, diabetes mellitus, osteoporosis, hypertension, and some types of cancer. Similarly, physi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::117eb9a16515da9d1d6b25f0eac295b9
https://doi.org/10.1249/mss.0b013e31825703f0
https://doi.org/10.1249/mss.0b013e31825703f0