Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Kristen, Jones"'
Autor:
Kristen Jones, Clare Keddy, Chelsea Jenkins, Katelyn Nicholson, Ujwal Shinde, Monika A. Davare
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract The ROS1 receptor tyrosine kinase (RTK) possesses the largest extracellular amino-terminal domain (ECD) among the human RTK family, yet the mechanisms regulating its activation are not fully understood. While chimeric ROS1 fusion proteins, r
Externí odkaz:
https://doaj.org/article/66839e6de01149af9218b507876cdf74
Autor:
Rajat Thawani, Matteo Repetto, Clare Keddy, Katelyn Nicholson, Kristen Jones, Kevin Nusser, Catherine Z. Beach, Guilherme Harada, Alexander Drilon, Monika A. Davare
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-11 (2024)
Abstract ROS1 tyrosine kinase inhibitors (TKIs) are highly effective in ROS1-positive non-small cell lung cancer, but resistance remains a challenge. We investigated the activity of various TKIs against wildtype and mutant ROS1, focusing on the emerg
Externí odkaz:
https://doaj.org/article/a2f0d426aed049d5ae3fab63257a9869
Autor:
Miglena Raykovska, Kristen Jones, Hristina Klecherova, Stefan Alexandrov, Nikolay Petkov, Tanya Hristova, Georgi Ivanov
Publikováno v:
Journal of Computer Applications in Archaeology, Vol 7, Iss 1, Pp 202–212-202–212 (2024)
Over the past decade, virtual reality has been quickly growing in popularity across disciplines including the fields of archaeology and cultural heritage. Despite numerous artifacts being uncovered each year by archaeological excavations around the w
Externí odkaz:
https://doaj.org/article/ee48f1cb4ff141109df2a2972e3480b9
Autor:
Kristen Jones, Mark Boschen, Grant Devilly, Jessica Vogler, Harley Flowers, Charlotte Winkleman, Martin Wullschleger
Publikováno v:
Health Sciences Review, Vol 10, Iss , Pp 100147- (2024)
Posttraumatic stress disorder (PTSD) is one of the most common psychiatric disorders following traumatic injury, affecting up to 51 % of adults admitted to trauma centres. Identification of people at risk of PTSD is an important component of holistic
Externí odkaz:
https://doaj.org/article/bbb93fdb19a9441ca76c5e3df8d216ae
Autor:
Rajat Thawani, Matteo Repetto, Clare Keddy, Katelyn Nicholson, Kristen Jones, Kevin Nusser, Catherine Z. Beach, Guilherme Harada, Alexander Drilon, Monika A. Davare
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/31196ad66dfb436eb7493219d57ee85d
Autor:
Yufei Wang, Jae-Won Cho, Gabriella Kastrunes, Alicia Buck, Cecile Razimbaud, Aedin C. Culhane, Jiusong Sun, David A. Braun, Toni K. Choueiri, Catherine J. Wu, Kristen Jones, Quang-De Nguyen, Zhu Zhu, Kevin Wei, Quan Zhu, Sabina Signoretti, Gordon J. Freeman, Martin Hemberg, Wayne A. Marasco
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108879- (2024)
Summary: One of the major barriers that have restricted successful use of chimeric antigen receptor (CAR) T cells in the treatment of solid tumors is an unfavorable tumor microenvironment (TME). We engineered CAR-T cells targeting carbonic anhydrase
Externí odkaz:
https://doaj.org/article/0c2301842fd04b6197a7bca08f019c78
Autor:
Sudarshan R Iyer, Kevin Nusser, Kristen Jones, Pushkar Shinde, Clare Keddy, Catherine Z Beach, Erin Aguero, Jeremy Force, Ujwal Shinde, Monika A Davare
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 10, Pp n/a-n/a (2023)
Abstract ROS1 is the largest receptor tyrosine kinase in the human genome. Rearrangements of the ROS1 gene result in oncogenic ROS1 kinase fusion proteins that are currently the only validated biomarkers for targeted therapy with ROS1 TKIs in patient
Externí odkaz:
https://doaj.org/article/808793d75f2f413c9604e051833dd047
Autor:
Melissa L. Vendetti, Seol Ju Esther Moon, Christopher C. Imes, Andrea Hergenroeder, Frank Sciurba, Elizabeth Lendermon, Joseph Pilewski, Dianxu Ren, Bambang Parmanto, Barbara Dewhirst, Bryan Willey, Kristen Jones, Matthew R. Morrell, Pablo Sanchez, Annette DeVito Dabbs
Publikováno v:
Contemporary Clinical Trials Communications, Vol 33, Iss , Pp 101097- (2023)
Background: Lung transplantation is an established treatment option for persons with advanced lung disease. After transplantation, lung function typically returns to near normal levels, however exercise capacity remains low due to chronic decondition
Externí odkaz:
https://doaj.org/article/6825aea235a74ec1ac5a566647e32d7e
Publikováno v:
Radiology Case Reports, Vol 17, Iss 7, Pp 2400-2403 (2022)
Wrong-level spinal surgery (WLSS) can lead to increased morbidity, cost, and worse long-term outcomes. Current intraoperative localization methods rely on counting spinal levels from a known reference location using fluoroscopy. Miscounting from a re
Externí odkaz:
https://doaj.org/article/25dda5faf28a483692cfabbfd06359fb
Publikováno v:
Global Bioethics, Vol 32, Iss 1, Pp 1-14 (2021)
The United Nations Educational, Scientific and Cultural Organisation’s (UNESCO) Declaration on Bioethics and Human Rights refers to the importance of cultural diversity and pluralism in ethical discourse and care of humanity. The aim of this meta-n
Externí odkaz:
https://doaj.org/article/f9130faaa8bd4448b129e8eff377d84c