Výsledky vyhledávání - "Kristen, Hopson"

Akademický článek

Protein re-surfacing of E. coli L-Asparaginase to evade pre-existing anti-drug antibodies and hypersensitivity responses

Autor: Ali Bootwala, Hyun Hwan An, Meghan Whitney Franklin, Benjamin J. Manning, Lucy Y. Xu, Shruti Panchal, Joseph D. Garlick, Reshica Baral, Michael E. Hudson, Gevorg Grigoryan, Mark A. Murakami, Kristen Hopson, Daniel S. Leventhal

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

The optimal use of many biotherapeutics is restricted by Anti-drug antibodies (ADAs) and hypersensitivity responses which can affect potency and ability to administer a treatment. Here we demonstrate that Re-surfacing can be utilized as a generalizab

Externí odkaz: https://doaj.org/article/4a3b4c9302ed43f8bcb616f28001d45c

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mRNA-encoded, constitutively active STINGV155M is a potent genetic adjuvant of antigen-specific CD8+ T cell response

Autor: Eric Yi-Chun Huang, Clayton Small, William Walker, Tal Zaks, Jared Iacovelli, Kristine Mckinney, Kristen Hopson, Sze-Wah Tse, Mychael Nguyen

Publikováno v: Molecular Therapy. 29:2227-2238

mRNA vaccines induce potent immune responses in preclinical models and clinical studies. Adjuvants are used to stimulate specific components of the immune system to increase immunogenicity of vaccines. We utilized a constitutively active mutation (V1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::18e4ec0b2702e16425dfb445cc1bf7d6
https://doi.org/10.1016/j.ymthe.2021.03.002

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mRNA vaccine–induced neoantigen-specific T cell immunity in patients with gastrointestinal cancer

Autor: Noam Levin, Kristen Hopson, Frank J. Lowery, Mackenzie L. Shindorf, Praveen D. Chatani, Tal Zaks, Maria R. Parkhurst, Stephanie L. Goff, Samantha Seitter, Biman C. Paria, Mohammad S. Jafferji, Jared J. Gartner, Gal Cafri, Rami Yossef, Steven A. Rosenberg, Paul F. Robbins, Todd D. Prickett, Anup Parikh, Christine T. McGowan

Publikováno v: J Clin Invest

BACKGROUND: Therapeutic vaccinations against cancer have mainly targeted differentiation antigens, cancer-testis antigens, and overexpressed antigens and have thus far resulted in little clinical benefit. Studies conducted by multiple groups have dem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::864dd04b18882bd68234b4b6df3dd8a4
https://doi.org/10.1172/jci134915

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mRNA-encoded, constitutively active STING

Autor: Sze-Wah, Tse, Kristine, McKinney, William, Walker, Mychael, Nguyen, Jared, Iacovelli, Clayton, Small, Kristen, Hopson, Tal, Zaks, Eric, Huang

Publikováno v: Molecular therapy : the journal of the American Society of Gene Therapy. 29(7)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7e23022f09bfa23ca0de862cdeb5f9f3
https://pubmed.ncbi.nlm.nih.gov/33677092

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Abstract 6539: Bioinformatics algorithm of mRNA-4157 identifies neoantigens with pre-existing TIL reactivities in colorectal tumors

Autor: Ben Breton, Wei Zheng, Tal Zaks, Joshua Frederick, Kristen Hopson, Iain Mcfadyen, Shan Zhong, Robert S. Meehan

Publikováno v: Cancer Research. 80:6539-6539

Background: Personalized cancer vaccines (PCVs) encode mutation-derived epitopes (neoantigens) predicted from each tumor's unique set of somatic mutations, and can trigger the activation of neoantigen-specific CD4+ and/or CD8+ T cells to target cance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::557f385603a846ff9f5df9a7d09fc9ca
https://doi.org/10.1158/1538-7445.am2020-6539

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A phase 1, open-label, multicenter study to assess the safety, tolerability, and immunogenicity of mRNA-4157 alone in subjects with resected solid tumors and in combination with pembrolizumab in subjects with unresectable solid tumors (Keynote-603)

Autor: Kinjal Mody, Daniel C. Cho, Howard A. Burris, Martin Gutierrez, Kristen Hopson, Robert S. Meehan, Shan Zhong, Tal Zaks, Pamela Sarah Cohen, Kristen Cowens, Justin F. Gainor, Celine Robert-Tissot, Joshua Frederick, Ben Breton, Karen Keating, Honghong Zhou, Jeffrey M. Clarke, Alverina Binanti-Berube, Manish R. Patel

Publikováno v: Journal of Global Oncology. 5:93-93

93 Background: T-cell targeting of mutation-derived epitopes (neoantigens) has been demonstrated to drive anti-tumor responses. Immunizing patients against such neoantigens in combination with a checkpoint inhibitor (CPI) may elicit greater anti-tumo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ec00b71c33ca3dc242f2d9116a9247dd
https://doi.org/10.1200/jgo.2019.5.suppl.93

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Abstract CT210: A Phase I, open-label, multicenter, dose escalation study of mRNA-2752, a lipid nanoparticle encapsulating mRNAs encoding human OX40L, IL-23, and IL-36γ, for intratumoral injection alone and in combination with immune checkpoint blockade

Autor: Kristen Hopson, Lisa Johansen, Sima Zacharek, Joshua Frederick, Jessica D. McDermott, Todd M. Bauer, Tal Zaks, Ding Wang, Robert S. Meehan, William Randolph, Antonio Jimeno, Manish R. Patel

Publikováno v: Cancer Research. 79:CT210-CT210

Recent outcomes of immune therapies have created a paradigm shift in cancer treatment. Significant improvements in cancers with clear unmet need have been demonstrated most impacted by administration of check point inhibitor (CPI) antibodies but not

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2a3a4c865c1c33868c03672311911832
https://doi.org/10.1158/1538-7445.am2019-ct210

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A phase I multicenter study to assess the safety, tolerability, and immunogenicity of mRNA-4157 alone in patients with resected solid tumors and in combination with pembrolizumab in patients with unresectable solid tumors

Autor: Ben Breton, Daniel C. Cho, Jeffrey M. Clarke, Celine Robert-Tissot, Manish R. Patel, Martin Gutierrez, Jing Sun, Tal Zaks, Shan Zhong, Bree Goldstein, Kristen Hopson, Howard A. Burris, Kinjal Mody, Scott K. Pruitt, Alverina Binanti-Berube, Joshua Frederick, Robert S. Meehan, Karen Keating, Justin F. Gainor

Publikováno v: Journal of Clinical Oncology. 37:2523-2523

2523 Background: T-cell targeting of mutation-derived epitopes (neoantigens) has been demonstrated to drive anti-tumor responses. Immunizing patients against such neoantigens in combination with a checkpoint inhibitor (CPI) may elicit greater anti-tu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a181c1331deb34ddbf1ee5d97e666cee
https://doi.org/10.1200/jco.2019.37.15_suppl.2523

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Immunogenicity and tolerability of personalized mRNA vaccine mRNA-4650 encoding defined neoantigens expressed by the autologous cancer

Autor: Gal Cafri, Jared J. Gartner, Tal Zaks, Steven A. Rosenberg, Kristen Hopson, Robert S. Meehan, Paul D. Robbins

Publikováno v: Journal of Clinical Oncology. 37:2643-2643

2643 Background: Therapeutic vaccination against cancer has proven very challenging with little clinical benefit. Vaccines against non-viral tumors have mainly targeted differentiation antigens, cancer testis antigens, and over-expressed antigens. Ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::97890fec107ad7e821f1db9c70a9cf67
https://doi.org/10.1200/jco.2019.37.15_suppl.2643

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