Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Kristen, Brennand"'
Autor:
Michael S. Breen, Andrew Browne, Gabriel E. Hoffman, Sofia Stathopoulos, Kristen Brennand, Joseph D. Buxbaum, Elodie Drapeau
Publikováno v:
Molecular Autism, Vol 11, Iss 1, Pp 1-23 (2020)
Abstract Background Phelan-McDermid syndrome (PMS) is a rare genetic disorder with high risk of autism spectrum disorder (ASD), intellectual disability, and language delay, and is caused by 22q13.3 deletions or mutations in the SHANK3 gene. To date,
Externí odkaz:
https://doaj.org/article/a9749c1a843848c3ab05b2ebc3fd11d6
Autor:
Kamini Singh, Maria Guadalupe Martinez, Jianan Lin, James Gregory, Trang Uyen Nguyen, Rawan Abdelaal, Kristy Kang, Kristen Brennand, Arnold Grünweller, Zhengqing Ouyang, Hemali Phatnani, Margaret Kielian, Hans-Guido Wendel
Publikováno v:
Viruses, Vol 14, Iss 7, p 1418 (2022)
Zika virus (ZIKV) and dengue virus (DENV) are members of the Flaviviridae family of RNA viruses and cause severe disease in humans. ZIKV and DENV share over 90% of their genome sequences, however, the clinical features of Zika and dengue infections a
Externí odkaz:
https://doaj.org/article/97db0caa53a3485ba9d516d0d9e2a0ff
Autor:
Seiji Ishii, Masaaki Torii, Alexander I. Son, Meenu Rajendraprasad, Yury M. Morozov, Yuka Imamura Kawasawa, Anna C. Salzberg, Mitsuaki Fujimoto, Kristen Brennand, Akira Nakai, Valerie Mezger, Fred H. Gage, Pasko Rakic, Kazue Hashimoto-Torii
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Prenatal exposure to environmental stressors is known to impair cortical development. Here the authors show that upon exposure to stressors, the activation of Hsf1-Hsp signalling is highly variable among cells in the embryonic cortex of mice, and eit
Externí odkaz:
https://doaj.org/article/799a96f9df824be3a9794751c745b994
Autor:
Kristen Brennand
Publikováno v:
American Journal of Psychiatry. 179:322-328
There is an urgent and unmet need to advance our ability to translate genetic studies of psychiatric disorders into clinically actionable information, which could transform diagnostics and even one day lead to novel (and potentially presymptomatic) t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88d132171e816c7486e773f731519641
https://doi.org/10.1176/appi.ajp.20220235
https://doi.org/10.1176/appi.ajp.20220235
Autor:
Michael McCarthy, Himanshu Mishra, Heather Wei, Kayla Rohr, Caroline Nievergelt, Adam Maihofer, Insu Ko, Paul Shilling, Martin Alda, Wade Berrettini, Kristen Brennand, Joseph Calabrese, William Coryell, Mark A. Frye, Fred Gage, Elliot Gershon, Melvin McInnis, John Nurnberger, Ketil Oedegaard, Peter Zandi, John Kelsoe
Bipolar disorder (BD) is characterized by mood episodes, disrupted circadian rhythms and gray matter reduction in the brain. Lithium is an effective pharmacotherapy for BD, but not all patients respond to treatment. Lithium has neuroprotective proper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0843039b596428e5dc33f1d29e842183
https://doi.org/10.21203/rs.3.rs-2003560/v1
https://doi.org/10.21203/rs.3.rs-2003560/v1
Autor:
Diana Xuan Yu, Francesco Paolo Di Giorgio, Jun Yao, Maria Carolina Marchetto, Kristen Brennand, Rebecca Wright, Arianna Mei, Lauren Mchenry, David Lisuk, Jaeson Michael Grasmick, Pedro Silberman, Giovanna Silberman, Roberto Jappelli, Fred H. Gage
Publikováno v:
Stem Cell Reports, Vol 2, Iss 3, Pp 295-310 (2014)
The availability of human pluripotent stem cells (hPSCs) offers the opportunity to generate lineage-specific cells to investigate mechanisms of human diseases specific to brain regions. Here, we report a differentiation paradigm for hPSCs that enrich
Externí odkaz:
https://doaj.org/article/5026ef6663eb4d668d41b5443ec01167
Autor:
Carina Seah, Rebecca Signer, Hannah Young, Tom Rusielewicz, Heather Bader, Changxin Xu, null Agathe dePins, Michael Breen, Daniel Paull, Matthew Girgenti, Rachel Yehuda, Kristen Brennand, Laura Huckins
Publikováno v:
Biological Psychiatry. 93:S11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3765172fdb9dd22035dc9af6f5db7f9
https://doi.org/10.1016/j.biopsych.2023.02.048
https://doi.org/10.1016/j.biopsych.2023.02.048
Autor:
Carina Seah, Tom Rusielewicz, Heather Bader, Changxin Xu, Hannah Young, Rebecca Signer, Agathe dePins, Christopher Hunter, PJ Michael Deans, Michael Breen, Daniel Paull, Kristen Brennand, Laura Huckins, Rachel Yehuda
Publikováno v:
European Neuropsychopharmacology. 63:e207-e208
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::caad4c8ddda5874327fea296d067666a
https://doi.org/10.1016/j.euroneuro.2022.07.372
https://doi.org/10.1016/j.euroneuro.2022.07.372
Autism spectrum disorder (ASD) is a highly heritable neurodevelopmental disorder characterized by deficits in social interactions and communication. Protein function altering variants in many genes have been shown to contribute to ASD risk; however,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83aec1c8c4bfcb5de93690d3adb33793
https://doi.org/10.1101/2022.02.28.22271620
https://doi.org/10.1101/2022.02.28.22271620
While inherited and de novo copy number variants (CNV) have been implicated in the genetic architecture of schizophrenia (SCZ), the contribution of somatic CNVs (sCNVs), present in some but not all cells of the body, remains unknown. Here we explore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bb5d15d85b1b57e9d4091223f014f6b
https://doi.org/10.1101/2021.12.24.21268385
https://doi.org/10.1101/2021.12.24.21268385