Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Kristele Pan"'
Autor:
Tracy Murphy, Stanley W.K. Ng, Ian King, Tong Zhang, Andrea Arruda, Jaime Claudio, Kristele Pan, Chantal Rockwell, Zhibin Lu, Natalie Stickle, Carl Virtanen, Vikas Gupta, Dawn Maze, Caroline McNamara, Aaron D. Schimmer, Andre C. Schuh, Hassan Sibai, Karen Yee, Dina Khalaf, Brian Leber, Mitchell Sabloff, Anne Tierens, Mark D. Minden, Tracy L. Stockley, Steven Chan, Jean C.Y. Wang
Publikováno v:
Blood. 140:9122-9124
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::201de96acf8c08aeb59dfd7ffa7ce7ec
https://doi.org/10.1182/blood-2022-171107
https://doi.org/10.1182/blood-2022-171107
Autor:
Etienne Coyaud, Rahul Satija, Michelle Chan-Seng-Yue, John E. Dick, Héléna Boutzen, Alex Murison, Shin ichiro Takayanagi, Kerstin B. Kaufmann, Laura García-Prat, Andy G.X. Zeng, Kristele Pan, Olga I. Gan, Estelle M.N. Laurent, Sasan Zandi, Stephanie Z. Xie, Brian Raught, Jessica McLeod, Efthymia Papalexi
Publikováno v:
Nature Immunology
Nature Immunology, 2021, Nature Immunology, 22, pp.723-734. ⟨10.1038/s41590-021-00925-1⟩
Nature Immunology, 2021, Nature Immunology, 22, pp.723-734. ⟨10.1038/s41590-021-00925-1⟩
Continuous supply of immune cells throughout life relies on the delicate balance in the hematopoietic stem cell (HSC) pool between long-term maintenance and meeting the demands of both normal blood production and unexpected stress conditions. Here we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63ef12b6a4c072ab47ad871009ff3dca
https://doi.org/10.1038/s41590-021-00925-1
https://doi.org/10.1038/s41590-021-00925-1
Autor:
Alex Murison, Andy G.X. Zeng, Mathieu Lupien, Elvin Wagenblast, Veronique Voisin, Stephanie Z. Xie, Darrien Parris, Florin Schneiter, Kerstin B. Kaufmann, Weijia Wang, Laura García-Prat, Sabrina A. Smith, Kinam Gupta, Michelle C. Shoong, Gabriela Krivdova, Olga I. Gan, Jocelyn Chen, Kristele Pan, Timm Schroeder, Shin-Ichiro Takayanagi, Jessica McLeod, John E. Dick, Michelle Chan-Seng-Yue
Publikováno v:
Cell Stem Cell, 28 (10)
It is critical to understand how human quiescent long-term hematopoietic stem cells (LT-HSCs) sense demand from daily and stress-mediated cues and then transition into bioenergetically active progeny to differentiate and meet these cellular needs. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dd0a23292b3827801ed27929e2b92cd
Autor:
Laura Garcia Prat, Kerstin Kaufmann, Florin Schneiter, Veronique Voisin, Alex Murison, Jocelyn Chen, Michelle Chan-Seng-Yue, Jessica McLeod, Olga Gan, Sabrina Smith, Michelle Shoong, Darrien Parris, Kristele Pan, Andy G Zeng, Gabriela Krivdova, Kinam Gupta, Shin-Ichiro Takayanagi, Elvin Wagenblast, Weija Wang, Mathieu Lupien, Timm Schroeder, Stephanie Xie, John Dick
Publikováno v:
Experimental Hematology. 100:S41-S42
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c8b5151795d04f0768981d389d3557e
https://doi.org/10.1016/j.exphem.2021.12.394
https://doi.org/10.1016/j.exphem.2021.12.394
Autor:
Narmin Ibrahimova, Steven M. Chan, Fiona Ferrera, Caroline J McNamara, Zhibin Lu, Jean C.Y. Wang, Vikas Gupta, Mitchell Sabloff, Dina Khalaf, Ian King, Andrea Arruda, Karen W.L. Yee, Tracy Murphy, Mark D. Minden, Jaime O. Claudio, Brian Leber, Tracy Stockley, Natalie Stickle, Stanley W.K. Ng, Hassan Sibai, Chantal Rockwell, Aaron D. Schimmer, Dawn Maze, Tong Zhang, Kristele Pan, Carl Virtanen, Andre C. Schuh, Anne Tierens
Publikováno v:
Blood. 136:35-36
Introduction: Acute myeloid leukemia (AML) is driven by a subpopulation of leukemia stem cells (LSCs), which possess properties such as quiescence and self-renewal that are linked to therapy resistance and relapse. The LSC17 score was derived from ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3f5a007decce8da7e9d30dcfffdc2d7
https://doi.org/10.1182/blood-2020-138943
https://doi.org/10.1182/blood-2020-138943
Autor:
Etienne Coyaud, Laura Garcia Prat, Olga I. Gan, Andy G.X. Zeng, Estelle M.N. Laurent, John E. Dick, Stephanie Z. Xie, Michelle Chan-Seng-Yue, Kerstin B. Kaufmann, Jessica McLeod, Shin-ichiro Takayanagi, Sasan Zandi, Rahul Satija, Kristele Pan, Brian Raught, Efthymia Papalexi
Publikováno v:
Blood. 136:5-5
The first insight into the complexity of post-transplant in vivo dynamics of hematopoietic stem cells (HSC) in humans was only recently showcased by examining longitudinal clonal contributions in gene therapy patients. Initial blood reconstitution wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab31366346b8548c954c9342323489c8
https://doi.org/10.1182/blood-2020-137725
https://doi.org/10.1182/blood-2020-137725
Autor:
Laura Garcia Prat, Weijia Wang, John E. Dick, Veronique Voisin, Kerstin B. Kaufmann, Michelle Shoong, Kristele Pan, Michelle Chan-Seng-Yue, Elvin Wagenblast, Shin-ichiro Takayanagi, Jessica McLeod, Timm Schroeder, Alex Murison, Olga I. Gan, Kinam Gupta, Stephanie Z. Xie, Florin Schneiter
Publikováno v:
Blood. 136:34-34
Human long-term hematopoietic stem cells (LT-HSC) residing at the top of the hematopoietic hierarchy must meet enormous daily demand (~10e11 cells daily) while also sustaining life-long maintenance of the stem cell pool through self-renewal. This hie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce1158534a6e3d4a8bf237ba8b9425d0
https://doi.org/10.1182/blood-2020-142671
https://doi.org/10.1182/blood-2020-142671
Autor:
Rahul Satija, John E. Dick, Etienne Coyaud, Estelle M.N. Laurent, Shin-ichiro Takayanagi, Jessica McLeod, Kerstin B. Kaufmann, Brian Raught, Efthymia Papalexi, Laura García-Prat, Michelle Chan-Seng-Yue, Stephanie Z. Xie, Andy G.X. Zeng, Kristele Pan, Olga I. Gan
Publikováno v:
Experimental Hematology. 88:S43
The mechanisms governing how human hematopoietic stem cells (HSC) balance their capacity for maintaining long-term (LT) regeneration with meeting daily and/or stress demands are unknown. We previously linked INKA1-mediated PAK4 inhibition along with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56bf9f3472f4353ea487f5ddb83d2ed7
https://doi.org/10.1016/j.exphem.2020.09.038
https://doi.org/10.1016/j.exphem.2020.09.038
Autor:
Michelle Shoong, Aditi Vedi, John E. Dick, Mark D. Minden, Gareth Holmes, Shin-ichiro Takayanagi, Chiara Luberto, Stephanie Z. Xie, Kerstin B. Kaufmann, Esther K. Lee, Ishita Patel, Elisa Laurenti, Laura García-Prat, Guy Romm, Olga I. Gan, Joseph Jargstorf, Elvin Wagenblast, Andy G.X. Zeng, Robin Ferrari, Kristele Pan, Veronique Voisin, Gary D. Bader
Publikováno v:
Cell Stem Cell
Summary Cellular stress responses serve as crucial decision points balancing persistence or culling of hematopoietic stem cells (HSCs) for lifelong blood production. Although strong stressors cull HSCs, the linkage between stress programs and self-re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c903eb9bcce1f5912590359a83801b6
https://doi.org/10.1016/j.stem.2019.09.008
https://doi.org/10.1016/j.stem.2019.09.008
Autor:
Kerstin B. Kaufmann, Jessica McLeod, John E. Dick, Laura Garcia Prat, Stephanie Z. Xie, Shinichiro Takayanagi, Kristele Pan, Olga I. Gan
Publikováno v:
Blood. 132:325-325
The controversy generated from recent murine studies as to whether hematopoietic stem cells (HSC) contribute to steady-state hematopoiesis emphasizes how limited our knowledge is of the mechanisms governing HSC self-renewal, activation and latency; a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::870b8cf2e946bd3f4e2d02566b4b589a
https://doi.org/10.1182/blood-2018-99-115065
https://doi.org/10.1182/blood-2018-99-115065