Výsledky vyhledávání - "Kristel Vercauteren"

Short Hairpin RNA-mediated Silencing of PRC (PGC-1-related Coactivator) Results in a Severe Respiratory Chain Deficiency Associated with the Proliferation of Aberrant Mitochondria

Autor: Richard C. Scarpulla, Natalie Gleyzer, Kristel Vercauteren

Publikováno v: Journal of Biological Chemistry. 284:2307-2319

PRC, a member of the PGC-1 coactivator family, is responsive to serum growth factors and up-regulated in proliferating cells. Here, we investigated its in vivo role by stably silencing PRC expression with two different short hairpin RNAs (shRNA1 and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6642b0f68ec9f55551e7e732071fd15
https://doi.org/10.1074/jbc.m806434200

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Autor: Kristel Vercauteren, Richard C. Scarpulla, Raymond A. Pasko, Natalie Gleyzer, Vita Maria Marino

Publikováno v: Molecular and Cellular Biology. 26:7409-7419

PGC-1-related coactivator (PRC) was initially characterized as a transcriptional coactivator that shares structural and functional features with PGC-1alpha. Both coactivators interact with nuclear respiratory factor 1 (NRF-1) and activate NRF-1 targe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79f1ac13e8f97097fefb3ee0a0a8a302
https://doi.org/10.1128/mcb.00585-06

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Cellular HIV-1 DNA Levels in Drug Sensitive Strains Are Equivalent to Those in Drug Resistant Strains in Newly-Diagnosed Patients in Europe

Autor: Demetriou, Victoria L. van de Vijver, David A. M. C. Kousiappa, Ioanna Balotta, Claudia Clotet, Bonaventura Grossman, Zehava and Jorgensen, Louise B. Lepej, Snjezana Z. Levy, Itzchak and Nielsen, Claus Paraskevis, Dimitrios Poljak, Mario Roman, Francois Ruiz, Lidia Schmidt, Jean-Claude Vandamme, Anne-Mieke Van Laethem, Kristel Vercauteren, Jurgen and Kostrikis, Leondios G.

Background: HIV-1 genotypic drug resistance is an important threat to the success of antiretroviral therapy and transmitted resistance has reached 9% prevalence in Europe. Studies have demonstrated that HIV-1 DNA load in peripheral blood mononuclear

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::80d168efc3e510c802fe279b4754a22a
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3146249

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Autor: Kristel Vercauteren, Natalie Gleyzer, Richard C. Scarpulla

Publikováno v: The Journal of biological chemistry. 283(18)

The PGC-1 family of regulated coactivators (PGC-1α, PGC-1β, and PRC) plays an important role in directing respiratory gene expression in response to environmental signals. Here, we show that PRC and PGC-1α differ in their interactions with nuclear

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ee52133703420789a78e6436f5f4d86
https://pubmed.ncbi.nlm.nih.gov/18343819

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Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators

Autor: Richard C. Scarpulla, Kristel Vercauteren, Natalie Gleyzer

Publikováno v: Molecular and cellular biology. 25(4)

In vertebrates, mitochondrial DNA (mtDNA) transcription is initiated bidirectionally from closely spaced promoters, HSP and LSP, within the D-loop regulatory region. Early studies demonstrated that mtDNA transcription requires mitochondrial RNA polym

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b3ef8ca2df2960d94491a8d92722a88
https://pubmed.ncbi.nlm.nih.gov/15684387

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Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation

Autor: Valeria Tiranti, Richard C. Scarpulla, Nancy Quesada, Joslyn K. Brunelle, Eric L. Bell, Massimo Zeviani, Navdeep S. Chandel, Kristel Vercauteren

Mammalian cells detect decreases in oxygen concentrations to activate a variety of responses that help cells adapt to low oxygen levels (hypoxia). One such response is stabilization of the protein HIF-1 alpha, a component of the transcription factor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a3e2a1fd2b042914ae9619431b52160
http://hdl.handle.net/11577/3354358

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