A simplified protocol for the generation of cortical brain organoids

Autor: Kristel N. Eigenhuis, Hedda B. Somsen, Mark van der Kroeg, Hilde Smeenk, Anne L. Korporaal, Steven A. Kushner, Femke M. S. de Vrij, Debbie L. C. van den Berg

Publikováno v: Frontiers in Cellular Neuroscience, Vol 17 (2023)

Human brain organoid technology has the potential to generate unprecedented insight into normal and aberrant brain development. It opens up a developmental time window in which the effects of gene or environmental perturbations can be experimentally

Externí odkaz: https://doaj.org/article/aa6e6d8657714516b4ada2e38f03bbef

Proteomics analysis identifies new markers associated with capillary cerebral amyloid angiopathy in Alzheimer’s disease

Autor: David C. Hondius, Kristel N. Eigenhuis, Tjado H. J. Morrema, Roel C. van der Schors, Pim van Nierop, Marianna Bugiani, Ka Wan Li, Jeroen J. M. Hoozemans, August B. Smit, Annemieke J. M. Rozemuller

Publikováno v: Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-19 (2018)

Abstract Alzheimer’s disease (AD) is characterized by amyloid beta (Aβ) deposits as plaques in the parenchyma and in the walls of cortical and leptomeningeal blood vessels of the brain called cerebral amyloid angiopathy (CAA). It is suggested that

Externí odkaz: https://doaj.org/article/912c27f58a9743b6b66d3b4bf2c7359b

Neuroinflammation is increased in the parietal cortex of atypical Alzheimer's disease

Autor: Jeroen J.M. Hoozemans, Annemieke J.M. Rozemuller, Baayla D.C. Boon, Kristel N. Eigenhuis, Boaz Lopuhaä, Wouter Kamphorst, Philip Scheltens, Femke H. Bouwman

Publikováno v: Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-16 (2018)
Journal of Neuroinflammation, 15(1). BioMed Central
Boon, B D C, Hoozemans, J J M, Lopuhaä, B, Eigenhuis, K N, Scheltens, P, Kamphorst, W, Rozemuller, A J M & Bouwman, F H 2018, ' Neuroinflammation is increased in the parietal cortex of atypical Alzheimer's disease ', Journal of Neuroinflammation, vol. 15, no. 1, pp. 170 . https://doi.org/10.1186/s12974-018-1180-y, https://doi.org/10.1186/s12974-018-1180-y

BACKGROUND: While most patients with Alzheimer's disease (AD) present with memory complaints, 30% of patients with early disease onset present with non-amnestic symptoms. This atypical presentation is thought to be caused by a different spreading of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64ca55d1c590878183085ac04ae094da
https://pubmed.ncbi.nlm.nih.gov/29843759