Výsledky vyhledávání - "Kristel Dewitt"

Possibilities and Limiting Factors for the Use of Dissolution as a Quality Control Tool to Detect Presence of Crystallinity for Amorphous Solid Dispersions: An Experimental and Modeling Investigation

Autor: Wei Xu, Kristel Dewitt, Filippos Kesisoglou, Melanie Marota, Thomas Colace, Andre Hermans

Publikováno v: Journal of Pharmaceutical Sciences. 108:3054-3062

In this article, experiments on tablets containing a model compound, grazoprevir, were conducted to explore how media selection for a quality control dissolution method can influence the sensitivity for the dissolution method toward drug crystallinit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::401299e33fb3b6f21bd2b9e3895d4eb9
https://doi.org/10.1016/j.xphs.2019.05.008

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Building a better particle: Leveraging physicochemical understanding of amorphous solid dispersions and a hierarchical particle approach for improved delivery at high drug loadings

Autor: Aaron S. Cote, Andre Hermans, Zhen Liu, Siwei Zhang, Jie Ren, Amanda K. P. Mann, Luke Schenck, Mikolaj Milewski, Kristel Dewitt

Publikováno v: International Journal of Pharmaceutics. 559:147-155

Amorphous solid dispersions are a promising option for managing compounds with poor aqueous solubility. However, for compounds with high melting points, thermal stability limitations, or poor solubility in volatile solvents, conventional routes of ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0707887cd7240ace2d041b93159cac9c
https://doi.org/10.1016/j.ijpharm.2019.01.009

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