Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Kristel Blackburn"'
Autor:
Sylvie Gomez, Karine Malagu, Thomas Presnot, Sally Ewen, Mihiro Sunose, Xiao-Ling Fan Cockcroft, Niall M. B. Martin, Alexandra Fundo, Armelle Le Gall, Keith Allan Menear, Hermann Gesine Johanna, Luisa Sebastian, Kristel Blackburn, Ian Hickson, Christine Bailey, Graeme C. M. Smith, Eleanor Torode, Kurt Gordon Pike
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5898-5901
A pharmacophore mapping approach, derived from previous experience of PIKK family enzymes, was used to identify a hit series of selective inhibitors of the mammalian target of rapamycin (mTOR). Subsequent refinement of the SAR around this hit series
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5847355afd0c1842bfbfbdcbcce2b812
https://doi.org/10.1016/j.bmcl.2009.08.069
https://doi.org/10.1016/j.bmcl.2009.08.069
Autor:
Claire Adcock, Francisco Cuenca Alonso, Niall M. B. Martin, Chris Mydlowski, Kristel Blackburn, Keith Allan Menear, Louise Copsey, Armelle Le Gall, Sylvie Gomez, Graeme C. M. Smith, Carlos Fenandez Lence, Hashim Javaid, Jan Drzewiecki, Alexandra Fundo
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(14)
We have previously described poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors based on a substituted benzyl-phthalazinone scaffold. As an alternative chemical template, a novel series of alkoxybenzamides were developed with restricted conformation t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0764f908b9acc17224a50fba6d1f26aa
https://pubmed.ncbi.nlm.nih.gov/18579376
https://pubmed.ncbi.nlm.nih.gov/18579376