Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Kristbjorn O. Gudmundsson"'
Autor:
Shweta Singh, Tanmoy Sarkar, Brad Jakubison, Stephen Gadomski, Andrew Spradlin, Kristbjorn O. Gudmundsson, Jonathan R. Keller
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Adult mammalian hematopoiesis is a dynamic cellular process that provides a continuous supply of myeloid, lymphoid, erythroid/megakaryocyte cells for host survival. This process is sustained by regulating hematopoietic stem cells (HSCs) quiescence, p
Externí odkaz:
https://doaj.org/article/6c698dcc8e404e2284a5a3cc0e3e0ba5
Autor:
Brad L. Jakubison, Tanmoy Sarkar, Kristbjorn O. Gudmundsson, Shweta Singh, Lei Sun, Holly M. Morris, Kimberly D. Klarmann, Jonathan R. Keller
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 13 (2022)
Defining mechanism(s) that maintain tissue stem quiescence is important for improving tissue regeneration, cell therapies, aging, and cancer. We report here that genetic ablation of Id2 in adult hematopoietic stem cells (HSCs) promotes increased HSC
Externí odkaz:
https://doaj.org/article/c11c062cb0a34b3e9bd58c5127f5532d
Autor:
Reut Suliman-Lavie, Ben Title, Yahel Cohen, Nanako Hamada, Maayan Tal, Nitzan Tal, Galya Monderer-Rothkoff, Bjorg Gudmundsdottir, Kristbjorn O. Gudmundsson, Jonathan R. Keller, Guo-Jen Huang, Koh-ichi Nagata, Yosef Yarom, Sagiv Shifman
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
POGZ is an autism spectrum disorder risk gene. How POGZ mutations result in ASD is unclear and animal models are lacking. Here, the authors generate a brain specific Pogz deficient mouse presenting ASD-like behaviour and show the effects of Pogz defi
Externí odkaz:
https://doaj.org/article/14ea55860cc94204933e8e502705deac
Autor:
Nhu Nguyen, Kristbjorn O. Gudmundsson, Anthony R. Soltis, Kevin Oakley, Kartik R. Roy, Yufen Han, Carmelo Gurnari, Jaroslaw P. Maciejewski, Gary Crouch, Patricia Ernst, Clifton L. Dalgard, Yang Du
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103679- (2022)
Summary: Abnormal activation of SETBP1 due to overexpression or missense mutations occurs frequently in various myeloid neoplasms and associates with poor prognosis. Direct activation of Hoxa9/Hoxa10/Myb transcription by SETBP1 and its missense mutan
Externí odkaz:
https://doaj.org/article/aec9793ae4a740d5aec5ddb6c0f79d33
Autor:
Stephen Gadomski, Satyendra K. Singh, Shweta Singh, Tanmoy Sarkar, Kimberly D. Klarmann, Maximillian Berenschot, Steven Seaman, Brad Jakubison, Kristbjorn O. Gudmundsson, Stephen Lockett, Jonathan R. Keller
Publikováno v:
Cell Reports, Vol 31, Iss 4, Pp - (2020)
Summary: Investigating mechanisms that regulate endothelial cell (EC) growth and survival is important for understanding EC homeostasis and how ECs maintain stem cell niches. We report here that targeted loss of Id genes in adult ECs results in dilat
Externí odkaz:
https://doaj.org/article/5e00d82cb9f044aeacd238721b815f03
Autor:
Bjorg Gudmundsdottir, Kristbjorn O. Gudmundsson, Kimberly D. Klarmann, Satyendra K. Singh, Lei Sun, Shweta Singh, Yang Du, Vincenzo Coppola, Luke Stockwin, Nhu Nguyen, Lino Tessarollo, Leifur Thorsteinsson, Olafur E. Sigurjonsson, Sveinn Gudmundsson, Thorunn Rafnar, John F. Tisdale, Jonathan R. Keller
Publikováno v:
Cell Reports, Vol 23, Iss 11, Pp 3236-3248 (2018)
Summary: Fetal globin genes are transcriptionally silenced during embryogenesis through hemoglobin switching. Strategies to derepress fetal globin expression in the adult could alleviate symptoms in sickle cell disease and β-thalassemia. We identifi
Externí odkaz:
https://doaj.org/article/e0d1e32368d04fa6970dd5594931da2a
Autor:
Reut Suliman-Lavie, Ben Title, Yahel Cohen, Nanako Hamada, Maayan Tal, Nitzan Tal, Galya Monderer-Rothkoff, Bjorg Gudmundsdottir, Kristbjorn O. Gudmundsson, Jonathan R. Keller, Guo-Jen Huang, Koh-ichi Nagata, Yosef Yarom, Sagiv Shifman
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/86f6f8a5fa734315aa46b75ea5b936d2
Autor:
Tanmoy Sarkar, Jennifer Lombardo, Shweta Singh, Kristbjorn O Gudmundsson, Holly M Morris, Shyam Saran, Jonathan R Keller
Publikováno v:
Blood Cancer Discovery. 4:A55-A55
Acute myeloid leukemia (AML) is thought to be maintained by quiescent leukemia stem cells (LSCs), which are resistant to chemotherapy and responsible for relapse. Recent evidence suggests that a subset of LSCs with higher oxidative phosphorylation an
Autor:
Brad L. Jakubison, Tanmoy Sarkar, Kristbjorn O. Gudmundsson, Shweta Singh, Lei Sun, Holly M. Morris, Kimberly D. Klarmann, Jonathan R. Keller
Publikováno v:
The Journal of clinical investigation. 132(13)
Defining mechanism(s) that maintain tissue stem quiescence is important for improving tissue regeneration, cell therapies, aging, and cancer. We report here that genetic ablation of Id2 in adult hematopoietic stem cells (HSCs) promotes increased HSC
Autor:
Kristbjorn O. Gudmundsson, Cara H. Olsen, Elizabeth A McCart, Jeannie M. Muir, Ognoon Mungunsukh, Roxane M. Bouten, Tiziana Di Pucchio, W. Bradley Rittase, W. Louis Wilkins, Yang Du, Michelle A. Bylicky, John E. Slaven, Regina M. Day, Sang-Ho Lee
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0256208 (2021)
PLoS ONE
PLoS ONE
Our laboratory has demonstrated that captopril, an angiotensin converting enzyme inhibitor, mitigates hematopoietic injury following total body irradiation in mice. Improved survival in mice is correlated with improved recovery of mature blood cells