Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Kristaps Klavins"'
Autor:
Jingzhi Fan, Theresa Schiemer, Vita Steinberga, Annija Vaska, Anastasija Metlova, Antons Sizovs, Janis Locs, Kristaps Klavins
Publikováno v:
Heliyon, Vol 10, Iss 22, Pp e39753- (2024)
Calcium phosphate (CaP) biomaterials have been widely used in hard tissue engineering, but their impact on cell metabolism is unclear. We synthesized and characterized hydroxyapatite, β-tricalcium phosphate, and biphasic calcium phosphate composites
Externí odkaz:
https://doaj.org/article/e0753889eded4073a047bc0dcce431ef
Autor:
Ilze Elbere, Zigmunds Orlovskis, Laura Ansone, Ivars Silamikelis, Lauma Jagare, Liga Birzniece, Kaspars Megnis, Kristaps Leskovskis, Annija Vaska, Maris Turks, Kristaps Klavins, Valdis Pirags, Monta Briviba, Janis Klovins
Publikováno v:
Gut Microbes, Vol 16, Iss 1 (2024)
Metformin is widely used for treating type 2 diabetes mellitus (T2D). However, the efficacy of metformin monotherapy is highly variable within the human population. Understanding the potential indirect or synergistic effects of metformin on gut micro
Externí odkaz:
https://doaj.org/article/69e2187b22ff47c3be1527681e9d49fe
Autor:
Adine Kanepa, Jingzhi Fan, Dmitrijs Rots, Annija Vaska, Laura Ansone, Monta Briviba, Janis Klovins, Natalja Kurjane, Kristaps Klavins
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionHereditary angioedema (HAE) is a rare, life-threatening autosomal dominant genetic disorder caused by a deficient and/or dysfunctional C1 esterase inhibitor (C1-INH) (type 1 and type 2) leading to recurrent episodes of edema. This study a
Externí odkaz:
https://doaj.org/article/9f189569867e49a6b9328584309c6ffd
Autor:
Julia S. Brunner, Loan Vulliard, Melanie Hofmann, Markus Kieler, Alexander Lercher, Andrea Vogel, Marion Russier, Johanna B. Brüggenthies, Martina Kerndl, Victoria Saferding, Birgit Niederreiter, Alexandra Junza, Annika Frauenstein, Carina Scholtysek, Yohei Mikami, Kristaps Klavins, Gerhard Krönke, Andreas Bergthaler, John J. O’Shea, Thomas Weichhart, Felix Meissner, Josef S. Smolen, Paul Cheng, Oscar Yanes, Jörg Menche, Peter J. Murray, Omar Sharif, Stephan Blüml, Gernot Schabbauer
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Multinucleated giant cells (MGCs) are important in the pathogenesis of various diseases. Here, the authors demonstrate that extracellular presence of the amino acid arginine is required for MGC formation and metabolism, suggesting a translational imp
Externí odkaz:
https://doaj.org/article/28055bd4c7454a9b869483a12530bfc2
Autor:
Laura Ansone, Monta Briviba, Ivars Silamikelis, Anna Terentjeva, Ingus Perkons, Liga Birzniece, Vita Rovite, Baiba Rozentale, Ludmila Viksna, Oksana Kolesova, Kristaps Klavins, Janis Klovins
Publikováno v:
Microbiology Spectrum, Vol 9, Iss 3 (2021)
ABSTRACT The heterogeneity in severity and outcome of COVID-19 cases points out the urgent need for early molecular characterization of patients followed by risk-stratified care. The main objective of this study was to evaluate the fluctuations of se
Externí odkaz:
https://doaj.org/article/a8441b1ccb9c4a108bdcfc6a79d47d13
Autor:
Gaurav Goyal, Junfeng Zheng, Elisabeth Adam, Georg Steffes, Mamta Jain, Kristaps Klavins, Thomas Hummel
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Little is known about the initial segregation of axonal and dendritic proteins during the differentiation of newly generated neurons. Here authors use a forward genetic screen to identify the role of sphingolipids in regulating the sub-cellular distr
Externí odkaz:
https://doaj.org/article/dac65b4ee54f4d37850c41772c6a9f87
Autor:
Jingzhi Fan, Keyvan Abedi-Dorcheh, Asma Sadat Vaziri, Fereshteh Kazemi-Aghdam, Saeed Rafieyan, Masoume Sohrabinejad, Mina Ghorbani, Fatemeh Rastegar Adib, Zahra Ghasemi, Kristaps Klavins, Vahid Jahed
Publikováno v:
Polymers, Vol 14, Iss 10, p 2097 (2022)
The musculoskeletal (MS) system consists of bone, cartilage, tendon, ligament, and skeletal muscle, which forms the basic framework of the human body. This system plays a vital role in appropriate body functions, including movement, the protection of
Externí odkaz:
https://doaj.org/article/219322edd5c84df0ae2c6906a839ea21
Publikováno v:
Metabolites, Vol 12, Iss 3, p 264 (2022)
Perturbations of metabolite profiles in human and canine enteropathies have been reported before. However, data in dogs are scarce and inconsistent. Currently, the metabolite profile in Yorkshire Terrier enteropathy (YTE) and the impact of treatment
Externí odkaz:
https://doaj.org/article/8cbad908ebd141a7bd24c20dd9967850
Autor:
Christopher Kremslehner, Anne Miller, Robert Nica, Ionela-Mariana Nagelreiter, Marie-Sophie Narzt, Bahar Golabi, Vera Vorstandlechner, Michael Mildner, Julia Lachner, Erwin Tschachler, Francesca Ferrara, Kristaps Klavins, Markus Schosserer, Johannes Grillari, Arvand Haschemi, Florian Gruber
Publikováno v:
Redox Biology, Vol 37, Iss , Pp 101583- (2020)
The epidermis is a multi-layered epithelium that consists mainly of keratinocytes which proliferate in its basal layer and then differentiate to form the stratum corneum, the skin's ultimate barrier to the environment. During differentiation keratino
Externí odkaz:
https://doaj.org/article/848b167f27eb4a08983cbf5b52fc64be
Autor:
Alexander Lercher, Alexandra M Popa, Csilla Viczenczova, Lindsay Kosack, Kristaps Klavins, Benedikt Agerer, Christiane A Opitz, Tobias V Lanz, Michael Platten, Andreas Bergthaler
Publikováno v:
PLoS Pathogens, Vol 16, Iss 10, p e1008973 (2020)
The liver is a central regulator of metabolic homeostasis and serum metabolite levels. Hepatocytes are the functional units of the liver parenchyma and not only responsible for turnover of biomolecules but also act as central immune signaling platfor
Externí odkaz:
https://doaj.org/article/c0014948cc8a407aa9e92e448df475d8